Values CatLog read from this paper
Resistance development in KPC-producing Klebsiella pneumoniae under ceftazidime/avibactam-meropenem pressure: KPC-2 Ω-loop mutations attenuate avibactam efficacy
PMID 42545018doi:10.1128/spectrum.00356-26Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 16 records (28 values) from this paper: KPC-2 from Klebsiella pneumoniae.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| KPC-2 | Klebsiella pneumoniae | ceftazidime | — | — | 0.5 | pH 7.2, 25 °C | Open record: KPC-2, ceftazidime |
| KPC-2 | Klebsiella pneumoniae | meropenem | 0.879 | 0.07188 | 12.3 | pH 7.2, 25 °C | Open record: KPC-2, meropenem |
| KPC-2variant D179Y | Klebsiella pneumoniae | ceftazidime | 0.016 | 0.001578 | 10 | pH 7.2, 25 °C | Open record: KPC-2 variant D179Y, ceftazidime |
| KPC-2variant D179Y | Klebsiella pneumoniae | meropenem | — | — | 0.033 | pH 7.2, 25 °C | Open record: KPC-2 variant D179Y, meropenem |
| KPC-2variant Del168-169_EL | Klebsiella pneumoniae | ceftazidime | — | — | 0.042 | pH 7.2, 25 °C | Open record: KPC-2 variant Del168-169_EL, ceftazidime |
| KPC-2variant Del168-169_EL | Klebsiella pneumoniae | meropenem | — | — | 0.12 | pH 7.2, 25 °C | Open record: KPC-2 variant Del168-169_EL, meropenem |
| KPC-2variant R164L | Klebsiella pneumoniae | ceftazidime | — | — | 0.15 | pH 7.2, 25 °C | Open record: KPC-2 variant R164L, ceftazidime |
| KPC-2variant R164L | Klebsiella pneumoniae | meropenem | — | — | 0.022 | pH 7.2, 25 °C | Open record: KPC-2 variant R164L, meropenem |
| KPC-2variant R164L/T243S | Klebsiella pneumoniae | ceftazidime | — | — | 0.067 | pH 7.2, 25 °C | Open record: KPC-2 variant R164L/T243S, ceftazidime |
| KPC-2variant R164L/T243S | Klebsiella pneumoniae | meropenem | 0.0317 | 0.1929 | 0.27 | pH 7.2, 25 °C | Open record: KPC-2 variant R164L/T243S, meropenem |
| KPC-2variant R164S | Klebsiella pneumoniae | ceftazidime | — | — | 1.4 | pH 7.2, 25 °C | Open record: KPC-2 variant R164S, ceftazidime |
| KPC-2variant R164S | Klebsiella pneumoniae | meropenem | 0.0677 | 0.1899 | 0.37 | pH 7.2, 25 °C | Open record: KPC-2 variant R164S, meropenem |
| KPC-2variant R164S/Ins275-NKDD | Klebsiella pneumoniae | ceftazidime | — | — | 0.48 | pH 7.2, 25 °C | Open record: KPC-2 variant R164S/Ins275-NKDD, ceftazidime |
| KPC-2variant R164S/Ins275-NKDD | Klebsiella pneumoniae | meropenem | 0.0322 | 0.07471 | 0.56 | pH 7.2, 25 °C | Open record: KPC-2 variant R164S/Ins275-NKDD, meropenem |
| KPC-2variant T243S | Klebsiella pneumoniae | ceftazidime | — | — | 1.3 | pH 7.2, 25 °C | Open record: KPC-2 variant T243S, ceftazidime |
| KPC-2variant T243S | Klebsiella pneumoniae | meropenem | 0.8185 | 0.1991 | 4.7 | pH 7.2, 25 °C | Open record: KPC-2 variant T243S, meropenem |