EC 1.1.1.103: L-threonine 3-dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 45 records for EC 1.1.1.103 from 4 papers, for 3 organisms. Names in these papers: L-threonine dehydrogenase (PhTDH), L-threonine dehydrogenase (tvTDH), L-threonine dehydrogenase (TcTDH), L-threonine dehydrogenase.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 81 records for EC 1.1.1.103 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.103 in Browse.

Papers

Papers with records for EC 1.1.1.103
Paper	Organisms	Records
Systematic Functional Analysis of Active-Site Residues in l-Threonine Dehydrogenase from Thermoplasma volcanium	Thermoplasma volcanium	19
Investigating a catalytic mechanism of hyperthermophilic L-threonine dehydrogenase from Pyrococcus horikoshii	Pyrococcus horikoshii	16
Inhibition of L-threonine dehydrogenase from Trypanosoma cruzi reduces glycine and acetate production and interferes with parasite growth and viability	Trypanosoma cruzi	6
Kinetic study of thermostable L-threonine dehydrogenase from an archaeon Pyrococcus horikoshii	Pyrococcus horikoshii	4

Records

Records for EC 1.1.1.103 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
L-threonine dehydrogenase	Thermoplasma volcanium	L-threonine	1.7	2.6	0.66	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase, L-threonine
L-threonine dehydrogenasevariant D180A	Thermoplasma volcanium	L-threonine	0.37	43	0.011	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase variant D180A, L-threonine
L-threonine dehydrogenasevariant G114A	Thermoplasma volcanium	L-threonine	1.6	0.6	2.7	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase variant G114A, L-threonine
L-threonine dehydrogenase (PhTDH)	Pyrococcus horikoshii	L-threoninecosubstrate NAD+	—	0.013	—	pH 7.5, 65 °C	PMID 16233775	Open record: L-threonine dehydrogenase (PhTDH), L-threonine
L-threonine dehydrogenase (PhTDH)	Pyrococcus horikoshii	L-threoninecosubstrate NADP+	—	0.447	—	pH 7.5, 65 °C	PMID 16233775	Open record: L-threonine dehydrogenase (PhTDH), L-threonine
L-threonine dehydrogenase (PhTDH)	Pyrococcus horikoshii	L-threonine	1.108	0.0118	94	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH), L-threonine
L-threonine dehydrogenase (PhTDH)	Pyrococcus horikoshii	NAD+	552	0.0101	5.48 × 10⁴	pH 7.5, 65 °C	PMID 16233775	Open record: L-threonine dehydrogenase (PhTDH), NAD+
L-threonine dehydrogenase (PhTDH)	Pyrococcus horikoshii	NAD+	—	0.0099	—	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH), NAD+
L-threonine dehydrogenase (PhTDH)	Pyrococcus horikoshii	NADP+	415	0.689	603	pH 7.5, 65 °C	PMID 16233775	Open record: L-threonine dehydrogenase (PhTDH), NADP+
L-threonine dehydrogenase (PhTDH)variant E152A	Pyrococcus horikoshii	L-threonine	0.00912	17.5	5.22 × 10⁻⁴	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant E152A, L-threonine
L-threonine dehydrogenase (PhTDH)variant E152A	Pyrococcus horikoshii	NAD+	—	0.0615	—	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant E152A, NAD+
L-threonine dehydrogenase (PhTDH)variant E152C	Pyrococcus horikoshii	L-threonine	0.242	0.308	0.787	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant E152C, L-threonine
L-threonine dehydrogenase (PhTDH)variant E152C	Pyrococcus horikoshii	NAD+	—	0.163	—	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant E152C, NAD+
L-threonine dehydrogenase (PhTDH)variant E152D	Pyrococcus horikoshii	L-threonine	3.5	0.237	14.77	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant E152D, L-threonine
L-threonine dehydrogenase (PhTDH)variant E152D	Pyrococcus horikoshii	NAD+	—	0.399	—	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant E152D, NAD+
L-threonine dehydrogenase (PhTDH)variant E152Q	Pyrococcus horikoshii	L-threonine	0.01028	50.6	2.03 × 10⁻⁴	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant E152Q, L-threonine
L-threonine dehydrogenase (PhTDH)variant E152Q	Pyrococcus horikoshii	NAD+	—	0.216	—	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant E152Q, NAD+
L-threonine dehydrogenase (PhTDH)variant E152S	Pyrococcus horikoshii	L-threonine	0.085	21.2	0.00402	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant E152S, L-threonine
L-threonine dehydrogenase (PhTDH)variant E152S	Pyrococcus horikoshii	NAD+	—	0.607	—	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant E152S, NAD+
L-threonine dehydrogenase (PhTDH)variant E152T	Pyrococcus horikoshii	L-threonine	0.0802	23.6	0.0034	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant E152T, L-threonine
L-threonine dehydrogenase (PhTDH)variant E152T	Pyrococcus horikoshii	NAD+	—	0.152	—	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant E152T, NAD+
L-threonine dehydrogenase (PhTDH)variant R294A	Pyrococcus horikoshii	L-threonine	0.1293	5.32	0.0243	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant R294A, L-threonine
L-threonine dehydrogenase (PhTDH)variant R294A	Pyrococcus horikoshii	NAD+	—	0.105	—	pH 7.5, 65 °C	PMID 18390572	Open record: L-threonine dehydrogenase (PhTDH) variant R294A, NAD+
L-threonine dehydrogenase (TcTDH)	Trypanosoma cruzi	L-threonine1 mM KCl	0.5	12.6	0.04	pH 7.6, 25 °C	PMID 39675710	Open record: L-threonine dehydrogenase (TcTDH), L-threonine
L-threonine dehydrogenase (TcTDH)	Trypanosoma cruzi	L-threonine10 mM KCl	6.4	13.1	0.49	pH 7.6, 25 °C	PMID 39675710	Open record: L-threonine dehydrogenase (TcTDH), L-threonine
L-threonine dehydrogenase (TcTDH)	Trypanosoma cruzi	L-threonine50 mM KCl	7.7	6.6	1.2	pH 7.6, 25 °C	PMID 39675710	Open record: L-threonine dehydrogenase (TcTDH), L-threonine
L-threonine dehydrogenase (TcTDH)	Trypanosoma cruzi	NAD+1 mM KCl	5.6	16	0.3	pH 7.6, 25 °C	PMID 39675710	Open record: L-threonine dehydrogenase (TcTDH), NAD+
L-threonine dehydrogenase (TcTDH)	Trypanosoma cruzi	NAD+10 mM KCl	10.3	1.8	5.8	pH 7.6, 25 °C	PMID 39675710	Open record: L-threonine dehydrogenase (TcTDH), NAD+
L-threonine dehydrogenase (TcTDH)	Trypanosoma cruzi	NAD+50 mM KCl	9	0.5	16.6	pH 7.6, 25 °C	PMID 39675710	Open record: L-threonine dehydrogenase (TcTDH), NAD+
L-threonine dehydrogenase (tvTDH)	Thermoplasma volcanium	L-serine	0.01	61	1.7 × 10⁻⁴	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH), L-serine
L-threonine dehydrogenase (tvTDH)	Thermoplasma volcanium	L-threonine	1.7	2.6	0.66	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH), L-threonine
L-threonine dehydrogenase (tvTDH)	Thermoplasma volcanium	L-threoninol	—	—	8.7 × 10⁻⁷	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH), L-threoninol
L-threonine dehydrogenase (tvTDH)variant D180A	Thermoplasma volcanium	L-threonine	0.37	43	0.011	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH) variant D180A, L-threonine
L-threonine dehydrogenase (tvTDH)variant G114A	Thermoplasma volcanium	(R)-(-)-1-amino-2-propanol	0.0085	360	2.3 × 10⁻⁵	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH) variant G114A, (R)-(-)-1-amino-2-propanol
L-threonine dehydrogenase (tvTDH)variant G114A	Thermoplasma volcanium	L-serine	0.013	180	5.4 × 10⁻⁴	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH) variant G114A, L-serine
L-threonine dehydrogenase (tvTDH)variant G114A	Thermoplasma volcanium	L-threonine	1.6	0.57	2.7	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH) variant G114A, L-threonine
L-threonine dehydrogenase (tvTDH)variant G114A	Thermoplasma volcanium	L-threoninol	—	—	3.5 × 10⁻⁶	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH) variant G114A, L-threoninol
L-threonine dehydrogenase (tvTDH)variant I113A	Thermoplasma volcanium	L-serine	0.026	1.8 × 10³	5.5 × 10⁻⁵	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH) variant I113A, L-serine
L-threonine dehydrogenase (tvTDH)variant I113A	Thermoplasma volcanium	L-threonine	0.73	8.8	0.11	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH) variant I113A, L-threonine
L-threonine dehydrogenase (tvTDH)variant S74A	Thermoplasma volcanium	L-threonine	—	—	0.0029	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH) variant S74A, L-threonine
L-threonine dehydrogenase (tvTDH)variant S74A	Thermoplasma volcanium	L-threoninol	—	—	3.9 × 10⁻⁶	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH) variant S74A, L-threoninol
L-threonine dehydrogenase (tvTDH)variant T178A	Thermoplasma volcanium	L-serine	0.014	1.6 × 10³	9.5 × 10⁻⁶	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH) variant T178A, L-serine
L-threonine dehydrogenase (tvTDH)variant T178A	Thermoplasma volcanium	L-threonine	—	—	0.035	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH) variant T178A, L-threonine
L-threonine dehydrogenase (tvTDH)variant T179A	Thermoplasma volcanium	L-threonine	—	—	0.0016	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH) variant T179A, L-threonine
L-threonine dehydrogenase (tvTDH)variant W273A	Thermoplasma volcanium	L-threonine	—	—	3.5 × 10⁻⁴	pH 10	PMID 31457655	Open record: L-threonine dehydrogenase (tvTDH) variant W273A, L-threonine