EC 1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin-forming)
OxidoreductasesOpen in Browse
CatLog read 59 records for EC 1.1.1.153 from 4 papers, for 4 organisms. Names in these papers: sepiapterin reductase, sepiapterin reductase (Dic-SR).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 25 records for EC 1.1.1.153 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.153 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells | Homo sapiens, Mus musculus | 27 |
| Carbonyl reductase activity of sepiapterin reductase from rat erythrocytes | Rattus norvegicus | 22 |
| Mutational analysis of sites in sepiapterin reductase phosphorylated by Ca2+/calmodulin-dependent protein kinase II | Homo sapiens, Rattus norvegicus | 8 |
| Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli | Dictyostelium discoideum | 2 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| sepiapterin reductase | Homo sapiens | 1,2-naphthoquinone | 0.2767 | 0.0021 | 131.8 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase, 1,2-naphthoquinone |
| sepiapterin reductase | Homo sapiens | 1,4-naphthoquinone | 0.0472 | 0.027 | 1.75 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase, 1,4-naphthoquinone |
| sepiapterin reductase | Homo sapiens | 2,3-dimethoxy-1,4-naphthoquinone | 0.0052 | 0.086 | 0.067 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase, 2,3-dimethoxy-1,4-naphthoquinone |
| sepiapterin reductase | Homo sapiens | 2-methylnaphthalene-1,4-dione | 0.016 | 0.0872 | 0.18 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase, 2-methylnaphthalene-1,4-dione |
| sepiapterin reductase | Homo sapiens | 9,10-phenanthrenequinone | 0.6278 | 0.0088 | 71.3 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase, 9,10-phenanthrenequinone |
| sepiapterin reductase | Homo sapiens | L-sepiapterin | 1.617 | 0.0254 | 63.7 | pH 6.4, 37 °C | PMID 23640889 | Open record: sepiapterin reductase, L-sepiapterin |
| sepiapterin reductase | Homo sapiens | NADH | 0.0033 | 0.11 | 0.033 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase, NADH |
| sepiapterin reductase | Homo sapiens | NADPH | 1.5 | 0.0123 | 100 | pH 6.4, 25 °C | PMID 11825621 | Open record: sepiapterin reductase, NADPH |
| sepiapterin reductase | Homo sapiens | NADPH | 0.0123 | 0.0302 | 0.42 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase, NADPH |
| sepiapterin reductase | Homo sapiens | sepiapterin | 1.3 | 0.0137 | 90 | pH 6.4, 25 °C | PMID 11825621 | Open record: sepiapterin reductase, sepiapterin |
| sepiapterin reductasevariant D257H | Homo sapiens | 9,10-phenanthrenequinone | 0.1073 | 0.0019 | 56.5 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase variant D257H, 9,10-phenanthrenequinone |
| sepiapterin reductasevariant D257H | Homo sapiens | L-sepiapterin | 0.157 | 0.0606 | 2.7 | pH 6.4, 37 °C | PMID 23640889 | Open record: sepiapterin reductase variant D257H, L-sepiapterin |
| sepiapterin reductasevariant G14S | Homo sapiens | 9,10-phenanthrenequinone | 0.0057 | 0.0501 | 0.17 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase variant G14S, 9,10-phenanthrenequinone |
| sepiapterin reductasevariant G18D | Homo sapiens | 9,10-phenanthrenequinone | 0.0483 | 0.4641 | 0.17 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase variant G18D, 9,10-phenanthrenequinone |
| sepiapterin reductasevariant K174L | Homo sapiens | 9,10-phenanthrenequinone | 0.0298 | 0.0277 | 1 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase variant K174L, 9,10-phenanthrenequinone |
| sepiapterin reductasevariant K174L | Homo sapiens | L-sepiapterin | 0.09 | 0.1698 | 0.5 | pH 6.4, 37 °C | PMID 23640889 | Open record: sepiapterin reductase variant K174L, L-sepiapterin |
| sepiapterin reductasevariant M205G | Homo sapiens | 9,10-phenanthrenequinone | 0.2242 | 0.0134 | 18 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase variant M205G, 9,10-phenanthrenequinone |
| sepiapterin reductasevariant M205G | Homo sapiens | L-sepiapterin | 0.428 | 0.1338 | 3.2 | pH 6.4, 37 °C | PMID 23640889 | Open record: sepiapterin reductase variant M205G, L-sepiapterin |
| sepiapterin reductasevariant N99A | Homo sapiens | 9,10-phenanthrenequinone | 0.29 | 0.126 | 2.3 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase variant N99A, 9,10-phenanthrenequinone |
| sepiapterin reductasevariant N99A | Homo sapiens | L-sepiapterin | 0.055 | 0.0941 | 0.67 | pH 6.4, 37 °C | PMID 23640889 | Open record: sepiapterin reductase variant N99A, L-sepiapterin |
| sepiapterin reductasevariant R42G | Homo sapiens | 9,10-phenanthrenequinone | 0.0983 | 0.0501 | 5.3 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase variant R42G, 9,10-phenanthrenequinone |
| sepiapterin reductasevariant R42G | Homo sapiens | L-sepiapterin | 0.053 | 0.0457 | 1.2 | pH 6.4, 37 °C | PMID 23640889 | Open record: sepiapterin reductase variant R42G, L-sepiapterin |
| sepiapterin reductasevariant S157A | Homo sapiens | 9,10-phenanthrenequinone | 0.0153 | 0.0032 | 4.8 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase variant S157A, 9,10-phenanthrenequinone |
| sepiapterin reductasevariant S157A | Homo sapiens | L-sepiapterin | 0.058 | 0.0503 | 1.2 | pH 6.4, 37 °C | PMID 23640889 | Open record: sepiapterin reductase variant S157A, L-sepiapterin |
| sepiapterin reductasevariant S213A | Homo sapiens | NADPH | 1.3 | 0.0115 | 100 | pH 6.4, 25 °C | PMID 11825621 | Open record: sepiapterin reductase variant S213A, NADPH |
| sepiapterin reductasevariant S213A | Homo sapiens | sepiapterin | 1.3 | 0.0135 | 90 | pH 6.4, 25 °C | PMID 11825621 | Open record: sepiapterin reductase variant S213A, sepiapterin |
| sepiapterin reductasevariant Y259A | Homo sapiens | 9,10-phenanthrenequinone | 0.805 | 0.0196 | 41 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase variant Y259A, 9,10-phenanthrenequinone |
| sepiapterin reductasevariant Y259A | Homo sapiens | L-sepiapterin | 0.603 | 0.0255 | 23.7 | pH 6.4, 37 °C | PMID 23640889 | Open record: sepiapterin reductase variant Y259A, L-sepiapterin |
| sepiapterin reductasevariant Δ257-261 | Homo sapiens | 9,10-phenanthrenequinone | 0.0058 | 0.116 | 0.050 calc. | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase variant Δ257-261, 9,10-phenanthrenequinone |
| sepiapterin reductase | Mus musculus | 9,10-phenanthrenequinone | 0.222 | 0.0063 | 35 | pH 7.8 | PMID 23640889 | Open record: sepiapterin reductase, 9,10-phenanthrenequinone |
| sepiapterin reductase | Mus musculus | L-sepiapterin | 0.807 | 0.0442 | 18 | pH 6.4, 37 °C | PMID 23640889 | Open record: sepiapterin reductase, L-sepiapterin |
| sepiapterin reductase | Rattus norvegicus | 1-Phenyl-1,2-propanedione0.1 mM NADPH; spectrophotometric NADPH oxidation | — | 0.0211 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, 1-Phenyl-1,2-propanedione |
| sepiapterin reductase | Rattus norvegicus | 1-Phenyl-1,2-propanedione0.3 mM NADH; spectrophotometric NADH oxidation | — | 0.1185 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, 1-Phenyl-1,2-propanedione |
| sepiapterin reductase | Rattus norvegicus | 2,4-Pentanedione | — | 5.19 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, 2,4-Pentanedione |
| sepiapterin reductase | Rattus norvegicus | 2-amino-4-hydroxy-6-lactoyl-7,8-dihydropteridine0.1 mM NADPH; spectrophotometric NADPH oxidation | — | 0.014 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, 2-amino-4-hydroxy-6-lactoyl-7,8-dihydropteridine |
| sepiapterin reductase | Rattus norvegicus | 2-amino-4-hydroxy-6-lactoyl-7,8-dihydropteridine0.3 mM NADH; spectrophotometric NADH oxidation | — | 0.0336 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, 2-amino-4-hydroxy-6-lactoyl-7,8-dihydropteridine |
| sepiapterin reductase | Rattus norvegicus | 9,10-Phenanthrenequinone | — | 8.2 × 10⁻⁴ | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, 9,10-Phenanthrenequinone |
| sepiapterin reductase | Rattus norvegicus | Acetoin | — | 29 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, Acetoin |
| sepiapterin reductase | Rattus norvegicus | Acetophenone | — | 1.11 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, Acetophenone |
| sepiapterin reductase | Rattus norvegicus | Benzil | — | 0.0183 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, Benzil |
| sepiapterin reductase | Rattus norvegicus | Benzylacetone | — | 0.043 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, Benzylacetone |
| sepiapterin reductase | Rattus norvegicus | Diacetyl0.1 mM NADPH; spectrophotometric NADPH oxidation | — | 1.02 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, Diacetyl |
| sepiapterin reductase | Rattus norvegicus | Diacetyl0.3 mM NADH; spectrophotometric NADH oxidation | — | 5.25 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, Diacetyl |
| sepiapterin reductase | Rattus norvegicus | Menadione | — | 0.18 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, Menadione |
| sepiapterin reductase | Rattus norvegicus | Methylglyoxal | — | 4.4 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, Methylglyoxal |
| sepiapterin reductase | Rattus norvegicus | NADH | — | 0.1255 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, NADH |
| sepiapterin reductase | Rattus norvegicus | NADPHSepiapterin held constant at 50 µM; cosubstrate Sepiapterin | — | 0.00154 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, NADPH |
| sepiapterin reductase | Rattus norvegicus | NADPH1-Phenyl-1,2-propanedione held constant at 100 µM | — | 0.00149 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, NADPH |
| sepiapterin reductase | Rattus norvegicus | NADPHDiacetyl held constant at 10 mM; cosubstrate Diacetyl | — | 0.00336 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, NADPH |
| sepiapterin reductase | Rattus norvegicus | NADPH | 10.7 | 0.0027 | 4 × 10³ | pH 6.4, 25 °C | PMID 11825621 | Open record: sepiapterin reductase, NADPH |
| sepiapterin reductase | Rattus norvegicus | p-Nitrobenzaldehyde | — | 0.43 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, p-Nitrobenzaldehyde |
| sepiapterin reductase | Rattus norvegicus | p-Quinone | — | 0.75 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, p-Quinone |
| sepiapterin reductase | Rattus norvegicus | Phenylglyoxal | — | 0.59 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, Phenylglyoxal |
| sepiapterin reductase | Rattus norvegicus | Propiophenone | — | 0.14 | — | pH 6.4, 25 °C | PMID 3904835 | Open record: sepiapterin reductase, Propiophenone |
| sepiapterin reductase | Rattus norvegicus | sepiapterin | 8.5 | 0.0115 | 700 | pH 6.4, 25 °C | PMID 11825621 | Open record: sepiapterin reductase, sepiapterin |
| sepiapterin reductasevariant S46A/S196A/S214A | Rattus norvegicus | NADPH | 10.5 | 0.0025 | 4.2 × 10³ | pH 6.4, 25 °C | PMID 11825621 | Open record: sepiapterin reductase variant S46A/S196A/S214A, NADPH |
| sepiapterin reductasevariant S46A/S196A/S214A | Rattus norvegicus | sepiapterin | 8.9 | 0.0122 | 700 | pH 6.4, 25 °C | PMID 11825621 | Open record: sepiapterin reductase variant S46A/S196A/S214A, sepiapterin |
| sepiapterin reductase (Dic-SR) | Dictyostelium discoideum | NADPH | — | 0.0518 | — | pH 5.5, 37 °C | PMID 10987137 | Open record: sepiapterin reductase (Dic-SR), NADPH |
| sepiapterin reductase (Dic-SR) | Dictyostelium discoideum | sepiapterin | — | 0.04 | — | pH 5.5, 37 °C | PMID 10987137 | Open record: sepiapterin reductase (Dic-SR), sepiapterin |