EC 1.1.1.169: 2-dehydropantoate 2-reductase
OxidoreductasesOpen in Browse
CatLog read 27 records for EC 1.1.1.169 from 3 papers, for 3 organisms. Names in these papers: ketopantoate reductase, ketopantoate reductase (Tk-KPR, TK1968 protein), ApbA (ketopantoic acid reductase).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 32 records for EC 1.1.1.169 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.169 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity | Escherichia coli | 14 |
| Identification and characterization of an archaeal ketopantoate reductase and its involvement in regulation of coenzyme A biosynthesis | Thermococcus kodakarensis | 11 |
| ApbA, the ketopantoate reductase enzyme of Salmonella typhimurium is required for the synthesis of thiamine via the alternative pyrimidine biosynthetic pathway | Salmonella typhimurium | 2 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| ApbA (ketopantoic acid reductase) | Salmonella typhimurium | 2-dehydropantoate (ketopantoic acid, KPA) | — | 0.742 | — | pH 6.25, 42 °C | PMID 9488683 | Open record: ApbA (ketopantoic acid reductase), 2-dehydropantoate (ketopantoic acid, KPA) |
| ApbA (ketopantoic acid reductase) | Salmonella typhimurium | NADPH | — | 0.776 | — | pH 6.25, 42 °C | PMID 9488683 | Open record: ApbA (ketopantoic acid reductase), NADPH |
| ketopantoate reductase | Escherichia coli | ketopantoate | 25 | 0.03 | 830 calc. | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase, ketopantoate |
| ketopantoate reductase | Escherichia coli | NADPH | — | 0.0073 | — | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase, NADPH |
| ketopantoate reductasevariant E256A | Escherichia coli | ketopantoate | 2.1 | 35 | 0.060 calc. | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase variant E256A, ketopantoate |
| ketopantoate reductasevariant E256A | Escherichia coli | NADPH | — | 0.0026 | — | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase variant E256A, NADPH |
| ketopantoate reductasevariant K176A | Escherichia coli | ketopantoate | 0.015 | 44 | 3.4 × 10⁻⁴ calc. | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase variant K176A, ketopantoate |
| ketopantoate reductasevariant K176A | Escherichia coli | NADPH | — | 0.0047 | — | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase variant K176A, NADPH |
| ketopantoate reductasevariant K72A | Escherichia coli | ketopantoate | 42.8 | 1.7 | 25 calc. | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase variant K72A, ketopantoate |
| ketopantoate reductasevariant K72A | Escherichia coli | NADPH | — | 0.068 | — | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase variant K72A, NADPH |
| ketopantoate reductasevariant N98A | Escherichia coli | ketopantoate | 1.6 | 4.4 | 0.36 calc. | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase variant N98A, ketopantoate |
| ketopantoate reductasevariant N98A | Escherichia coli | NADPH | — | 0.0026 | — | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase variant N98A, NADPH |
| ketopantoate reductasevariant R31A | Escherichia coli | ketopantoate | 37 | 0.05 | 740 calc. | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase variant R31A, ketopantoate |
| ketopantoate reductasevariant R31A | Escherichia coli | NADPH | — | 0.03 | — | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase variant R31A, NADPH |
| ketopantoate reductasevariant S244A | Escherichia coli | ketopantoate | 15 | 7 | 2.1 calc. | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase variant S244A, ketopantoate |
| ketopantoate reductasevariant S244A | Escherichia coli | NADPH | — | 0.0023 | — | pH 7.6, 25 °C | PMID 17229734 | Open record: ketopantoate reductase variant S244A, NADPH |
| ketopantoate reductase (Tk-KPR, TK1968 protein) | Thermococcus kodakarensis | 2-oxopantoate | 23.1 | 0.00603 | 3.83 × 10³ | pH 6.4, 70 °C | PMID 23941541 | Open record: ketopantoate reductase (Tk-KPR, TK1968 protein), 2-oxopantoate |
| ketopantoate reductase (Tk-KPR, TK1968 protein) | Thermococcus kodakarensis | D-pantoate | 3.8 | 0.13 | 29 | pH 6.4, 70 °C | PMID 23941541 | Open record: ketopantoate reductase (Tk-KPR, TK1968 protein), D-pantoate |
| ketopantoate reductase (Tk-KPR, TK1968 protein) | Thermococcus kodakarensis | L-pantoate | 3.17 | 2.04 | 2 | pH 6.4, 70 °C | PMID 23941541 | Open record: ketopantoate reductase (Tk-KPR, TK1968 protein), L-pantoate |
| ketopantoate reductase (Tk-KPR, TK1968 protein) | Thermococcus kodakarensis | NAD+ | 2.41 | 0.0409 | 60 | pH 6.4, 70 °C | PMID 23941541 | Open record: ketopantoate reductase (Tk-KPR, TK1968 protein), NAD+ |
| ketopantoate reductase (Tk-KPR, TK1968 protein) | Thermococcus kodakarensis | NADHTable 1 | 19.7 | 0.00301 | 6.54 × 10³ | pH 6.4, 70 °C | PMID 23941541 | Open record: ketopantoate reductase (Tk-KPR, TK1968 protein), NADH |
| ketopantoate reductase (Tk-KPR, TK1968 protein) | Thermococcus kodakarensis | NADHCoA inhibition series (Table 2): no CoA; Table 2 | — | 0.0036 | — | pH 6.4, 70 °C | PMID 23941541 | Open record: ketopantoate reductase (Tk-KPR, TK1968 protein), NADH |
| ketopantoate reductase (Tk-KPR, TK1968 protein) | Thermococcus kodakarensis | NADHapparent Km; Table 2 | — | 0.0153 | — | pH 6.4, 70 °C | PMID 23941541 | Open record: ketopantoate reductase (Tk-KPR, TK1968 protein), NADH |
| ketopantoate reductase (Tk-KPR, TK1968 protein) | Thermococcus kodakarensis | NADHapparent Km; Table 2 | — | 0.0366 | — | pH 6.4, 70 °C | PMID 23941541 | Open record: ketopantoate reductase (Tk-KPR, TK1968 protein), NADH |
| ketopantoate reductase (Tk-KPR, TK1968 protein) | Thermococcus kodakarensis | NADHapparent Km; Table 2 | — | 0.0522 | — | pH 6.4, 70 °C | PMID 23941541 | Open record: ketopantoate reductase (Tk-KPR, TK1968 protein), NADH |
| ketopantoate reductase (Tk-KPR, TK1968 protein) | Thermococcus kodakarensis | NADHCoA inhibition series (Table 2): global fit of data at 0 | — | 0.0035 | — | pH 6.4, 70 °C | PMID 23941541 | Open record: ketopantoate reductase (Tk-KPR, TK1968 protein), NADH |
| ketopantoate reductase (Tk-KPR, TK1968 protein) | Thermococcus kodakarensis | NADPH | 2.22 | 0.00135 | 1.64 × 10³ | pH 6.4, 70 °C | PMID 23941541 | Open record: ketopantoate reductase (Tk-KPR, TK1968 protein), NADPH |