EC 1.1.1.196: 15-hydroxyprostaglandin-D dehydrogenase (NADP+)
OxidoreductasesOpen in Browse
CatLog read 13 records for EC 1.1.1.196 from 3 papers, for 1 organism. Names in these papers: carbonyl reductase 1 (hCBR1), CBR1 I88, CBR1 V88, human carbonyl reductase 1 (hCBR1).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 12 records for EC 1.1.1.196 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.196 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity | Homo sapiens | 8 |
| Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1 | Homo sapiens | 4 |
| Human carbonyl reductase 1 is an S-nitrosoglutathione reductase | Homo sapiens | 1 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| carbonyl reductase 1 (hCBR1) | Homo sapiens | 4-benzoylpyridine | 6.7 | 0.36 | 18 | pH 6.5, 25 °C | PMID 18493841 | Open record: carbonyl reductase 1 (hCBR1), 4-benzoylpyridine |
| carbonyl reductase 1 (hCBR1) | Homo sapiens | 4-nitrobenzaldehyde | 3.2 | 1.3 | 2.5 | pH 6.5, 25 °C | PMID 18493841 | Open record: carbonyl reductase 1 (hCBR1), 4-nitrobenzaldehyde |
| carbonyl reductase 1 (hCBR1) | Homo sapiens | menadione (2-methyl-1,4-naphthoquinone) | 7.3 | 0.028 | 270 | pH 6.5, 25 °C | PMID 18493841 | Open record: carbonyl reductase 1 (hCBR1), menadione (2-methyl-1,4-naphthoquinone) |
| carbonyl reductase 1 (hCBR1) | Homo sapiens | NADPH | — | 0.0062 | — | pH 6.5, 25 °C | PMID 18493841 | Open record: carbonyl reductase 1 (hCBR1), NADPH |
| CBR1 I88 | Homo sapiens | daunorubicin | 61 | 0.14 | 440 calc. | pH 7.4, 37 °C | PMID 17344335 | Open record: CBR1 I88, daunorubicin |
| CBR1 I88 | Homo sapiens | menadione | 85 | 0.055 | 1.5 × 10³ calc. | pH 7.4, 37 °C | PMID 17344335 | Open record: CBR1 I88, menadione |
| CBR1 I88 | Homo sapiens | NADPH | 149 | 0.343 | 434 calc. | pH 7.4, 37 °C | PMID 17344335 | Open record: CBR1 I88, NADPH |
| CBR1 I88 | Homo sapiens | prostaglandin E2 | 18 | 0.32 | 56 calc. | pH 7.4, 37 °C | PMID 17344335 | Open record: CBR1 I88, prostaglandin E2 |
| CBR1 V88 | Homo sapiens | daunorubicin | 91 | 0.173 | 530 calc. | pH 7.4, 37 °C | PMID 17344335 | Open record: CBR1 V88, daunorubicin |
| CBR1 V88 | Homo sapiens | menadione | 110 | 0.042 | 2.6 × 10³ calc. | pH 7.4, 37 °C | PMID 17344335 | Open record: CBR1 V88, menadione |
| CBR1 V88 | Homo sapiens | NADPH | 179 | 0.247 | 725 calc. | pH 7.4, 37 °C | PMID 17344335 | Open record: CBR1 V88, NADPH |
| CBR1 V88 | Homo sapiens | prostaglandin E2 | 25 | 0.309 | 81 calc. | pH 7.4, 37 °C | PMID 17344335 | Open record: CBR1 V88, prostaglandin E2 |
| human carbonyl reductase 1 (hCBR1) | Homo sapiens | S-nitrosoglutathione | 7.5 | 0.0301 | 249.2 | pH 6.8 | PMID 18826943 | Open record: human carbonyl reductase 1 (hCBR1), S-nitrosoglutathione |