CatLogenzyme kinetics catalog

EC 1.1.1.206: tropinone reductase I

OxidoreductasesOpen in Browse

CatLog read 75 records for EC 1.1.1.206 from 6 papers, for 6 organisms. Names in these papers: tropine forming tropinone reductase (WsTR-I), tropinone reductase I (TR-I), tropinone reductase I (TR-I, tropine-forming), tropinone reductase CoTR and 3 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 15 records for EC 1.1.1.206 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.206 in Browse.

Papers

PaperOrganismsRecords
Tropine forming tropinone reductase gene from Withania somnifera (Ashwagandha): biochemical characteristics of the recombinant enzyme and novel physiological overtones of tissue-wide gene expression…Withania somnifera24
Site-directed mutagenesis of putative substrate-binding residues reveals a mechanism controlling the different stereospecificities of two tropinone reductasesDatura stramonium22
Two Tropinone Reductases with Distinct Stereospecificities from Cultured Roots of Hyoscyamus nigerHyoscyamus niger10
The functional divergence of short-chain dehydrogenases involved in tropinone reductionCochlearia officinalis9
Functional characterisation of a tropine-forming reductase gene from Brugmansia arborea, a woody plant species producing tropane alkaloidsBrugmansia arborea, Datura stramonium6
Molecular cloning and catalytic characterization of a recombinant tropine biosynthetic tropinone reductase from Withania coagulans leafWithania coagulans4

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
tropine forming tropinone reductase (WsTR-I)Withania somnifera3-methylcyclohexanone—2.11—pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somnifera3-methylcyclohexanonekcat per active site9.23——pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somnifera3-methylcyclohexanone——4.38pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somnifera3-methylcyclohexanonekcat per active site18.46——pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferaN-methyl-piperidine—1.74—pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferaN-methyl-piperidinekcat per active site8.97——pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferaN-methyl-piperidine——5.17pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferaN-methyl-piperidinekcat per active site17.95——pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferaNADP+—0.09615—pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferaNADP+kcat per active site0.54——pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferaNADP+——0.559pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferaNADP+kcat per active site1.06——pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferaNADPH—4.3 × 10⁻⁴—pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferaNADPHkcat per active site33.34——pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferaNADPH——7.74 × 10⁴pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferaNADPHkcat per active site66.68——pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferatropine—114.9—pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferatropinekcat per active site1.67——pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferatropine——0.014pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferatropinekcat per active site3.33——pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferatropinone—1.27—pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferatropinonekcat per active site9.51——pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferatropinone——7.49pH 6.7, 30 °CPMID 24086372Open
tropine forming tropinone reductase (WsTR-I)Withania somniferatropinonekcat per active site19.03——pH 6.7, 30 °CPMID 24086372Open
tropinone reductase CoTRCochlearia officinalis1-methyl-4-piperidinone—7.5832.374pH 6.4, 30 °CPMID 18221363Open
tropinone reductase CoTRCochlearia officinalis1-propyl-4-piperidinone—1.3420.51pH 6.4, 30 °CPMID 18221363Open
tropinone reductase CoTRCochlearia officinalis3-methylcyclohexanone—0.0135.171pH 6.4, 30 °CPMID 18221363Open
tropinone reductase CoTRCochlearia officinalis4-methylcyclohexanone—0.01595.94pH 6.4, 30 °CPMID 18221363Open
tropinone reductase CoTRCochlearia officinalis8-thiabicyclo[3.2.1]octan-3-one—0.0421.096pH 6.4, 30 °CPMID 18221363Open
tropinone reductase CoTRCochlearia officinalisnortropinone—2.0020.0089pH 6.4, 30 °CPMID 18221363Open
tropinone reductase CoTRCochlearia officinalisQuinuclidinone—2.6360.0318pH 6.4, 30 °CPMID 18221363Open
tropinone reductase CoTRCochlearia officinalistropinoneTable 1—3.290.0073pH 6.4, 30 °CPMID 18221363Open
tropinone reductase CoTRCochlearia officinalistropinonein the text0.023——pH 6.4, 30 °CPMID 18221363Open
tropinone reductase I (BaTRI)Brugmansia arborea3-quinuclidinone hydrochloride0.545.170.1045pH 6.4, 30 °CPMID 26988730Open
tropinone reductase I (BaTRI)Brugmansia arborea4-methylcyclohexanone4.670.4610.15pH 6.4, 30 °CPMID 26988730Open
tropinone reductase I (BaTRI)Brugmansia arboreatropine5.690.5610.16pH 9.6, 30 °CPMID 26988730Open
tropinone reductase I (BaTRI)Brugmansia arboreatropinone2.932.651.106pH 6.4, 30 °CPMID 26988730Open
tropinone reductase I (DsTRI)Datura stramoniumtropine3.30.349.706pH 9.6, 30 °CPMID 26988730Open
tropinone reductase I (DsTRI)Datura stramoniumtropinone2.44.180.5742pH 6.4, 30 °CPMID 26988730Open
tropinone reductase I (TR-I)Datura stramoniumNADPH—0.0116—pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)Datura stramoniumtropinone25.60.117219 calc.pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant A160SDatura stramoniumNADPH—0.045—pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant A160SDatura stramoniumtropinone15.10.17586.3 calc.pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant A160S/V168EDatura stramoniumNADPH—0.037—pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant A160S/V168EDatura stramoniumtropinone0.17813.30.0134 calc.pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant H112FDatura stramoniumNADPH—0.0167—pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant H112FDatura stramoniumtropinone5.160.510 calc.pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant H112YDatura stramoniumNADPH—0.0207—pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant H112YDatura stramoniumtropinone16.40.33848.5 calc.pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant H112Y/A160SDatura stramoniumNADPH—0.0822—pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant H112Y/A160SDatura stramoniumtropinone8.421.445.85 calc.pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant H112Y/A160S/V168EDatura stramoniumNADPH—0.0825—pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant H112Y/A160S/V168EDatura stramoniumtropinone0.2156.010.0358 calc.pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant H112Y/A160S/V168E/I223L/F226LDatura stramoniumNADPH—0.0411—pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant H112Y/A160S/V168E/I223L/F226LDatura stramoniumtropinone0.1353.880.0348 calc.pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant I223L/F226LDatura stramoniumNADPH—0.0132—pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant I223L/F226LDatura stramoniumtropinone21.85.114.27 calc.pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant V168EDatura stramoniumNADPH—0.0396—pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant V168EDatura stramoniumtropinone0.6037.40.082 calc.pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant V168E/H112YDatura stramoniumNADPH—0.0564—pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I)variant V168E/H112YDatura stramoniumtropinone0.3897.540.0516 calc.pH 7, 28 °CPMID 10347221Open
tropinone reductase I (TR-I, tropine-forming)Hyoscyamus niger3-Methylcyclohexanone—0.041—pH 5.9PMID 16653065Open
tropinone reductase I (TR-I, tropine-forming)Hyoscyamus niger3-Quinuclidinone—1.81—pH 5.9PMID 16653065Open
tropinone reductase I (TR-I, tropine-forming)Hyoscyamus niger3α-hydroxytropane—2.6—PMID 16653065Open
tropinone reductase I (TR-I, tropine-forming)Hyoscyamus niger4-Ethylcyclohexanone—0.03—pH 5.9PMID 16653065Open
tropinone reductase I (TR-I, tropine-forming)Hyoscyamus niger4-Methylcyclohexanone—0.012—pH 5.9PMID 16653065Open
tropinone reductase I (TR-I, tropine-forming)Hyoscyamus niger8-thiabicyclo[3.2.1]octan-3-one—0.033—pH 5.9PMID 16653065Open
tropinone reductase I (TR-I, tropine-forming)Hyoscyamus nigerN-Methyl-4-piperidone—0.231—pH 5.9PMID 16653065Open
tropinone reductase I (TR-I, tropine-forming)Hyoscyamus nigerNADP+—0.0415—PMID 16653065Open
tropinone reductase I (TR-I, tropine-forming)Hyoscyamus nigerNADPH—0.0113—pH 5.9PMID 16653065Open
tropinone reductase I (TR-I, tropine-forming)Hyoscyamus nigertropinone—1.01—pH 5.9PMID 16653065Open
tropinone reductase I (WcTR-I)Withania coagulansbeta-nicotinamide adenine dinucleotide phosphate2.940.208314pH 6.6, 30 °CPMID 23266822Open
tropinone reductase I (WcTR-I)Withania coagulansbeta-nicotinamide adenine dinucleotide phosphate reduced6.760.126653pH 6.6, 30 °CPMID 23266822Open
tropinone reductase I (WcTR-I)Withania coagulanstropine1.8726.310.071pH 6.6, 30 °CPMID 23266822Open
tropinone reductase I (WcTR-I)Withania coagulanstropinone16.741.45111.53pH 6.6, 30 °CPMID 23266822Open