CatLogenzyme kinetics catalog

EC 1.1.1.3: homoserine dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 48 records for EC 1.1.1.3 from 7 papers, for 6 organisms. Names in these papers: bifunctional aspartate kinase-homoserine dehydrogenase 1 (GmAK-HSD-1), HSD activity, bifunctional aspartate kinase-homoserine dehydrogenase 2 (GmAK-HSD-2), HSD activity, homoserine dehydrogenase (HseDH), homoserine dehydrogenase, monofunctional (GmHSD) and 7 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 27 records for EC 1.1.1.3 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.3 in Browse.

Papers

PaperOrganismsRecords
Threonine-insensitive homoserine dehydrogenase from soybean: genomic organization, kinetic mechanism, and in vivo activityGlycine max24
Crystal Structures of a Hyperthermophilic Archaeal Homoserine Dehydrogenase Suggest a Novel Cofactor Binding Mode for OxidoreductasesPyrococcus horikoshii8
Production and characterization of bifunctional enzymes. Domain swapping to produce new bifunctional enzymes in the aspartate pathwayEscherichia coli7
An integrated study of threonine-pathway enzyme kinetics in Escherichia coliEscherichia coli4
Identification of six novel allosteric effectors of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase isoforms. Physiological context sets the specificityArabidopsis thaliana2
Molecular and Enzymatic Features of Homoserine Dehydrogenase from Bacillus subtilisBacillus subtilis2
Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acidSaccharomyces cerevisiae1

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
AK III-HDH I+ hybrid bifunctional enzyme (aspartokinase III fused to homoserine dehydrogenase I with its interface region)chimera AK III-HDH I+Escherichia coliaspartate0.160.510.31PMID 11888289Open
AK III-HDH I+ hybrid bifunctional enzyme (aspartokinase III fused to homoserine dehydrogenase I with its interface region)chimera AK III-HDH I+Escherichia colihomoserine240.4159PMID 11888289Open
aspartate kinase-homoserine dehydrogenase isoform I (AK-HSDH I), homoserine dehydrogenase activity (HSDH I)Arabidopsis thalianaaspartate semialdehyde2450.29850 calc.pH 8, 30 °CPMID 16216875Open
aspartate kinase-homoserine dehydrogenase isoform II (AK-HSDH II), homoserine dehydrogenase activity (HSDH II)Arabidopsis thalianaaspartate semialdehyde1960.311630 calc.pH 8, 30 °CPMID 16216875Open
aspartokinase-homoserine dehydrogenase I (AK-HDH I)Escherichia coliaspartate0.390.630.63PMID 11888289Open
aspartokinase-homoserine dehydrogenase I (AK-HDH I)Escherichia colihomoserine0.241.20.21PMID 11888289Open
aspartokinase-homoserine dehydrogenase I (AK-HDH I)AK I domain (thrA1)Escherichia coliaspartate6.30.4714PMID 11888289Open
aspartokinase-homoserine dehydrogenase I (AK-HDH I)HDH I domain (thrA2)Escherichia colihomoserine0.5117.20.03PMID 11888289Open
aspartokinase-homoserine dehydrogenase I (AK-HDH I)HDH I+ domain (thrA2+)Escherichia colihomoserine3.30.684.9PMID 11888289Open
bifunctional aspartate kinase-homoserine dehydrogenase 1 (GmAK-HSD-1), HSD activityGlycine maxhomoserinecosubstrate NAD^+79.570.731pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 1 (GmAK-HSD-1), HSD activityGlycine maxhomoserinecosubstrate NADP^+0.04231.080.0392pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 1 (GmAK-HSD-1), HSD activityGlycine maxL-aspartate-beta-semialdehydecosubstrate NADH19.31.1916.22pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 1 (GmAK-HSD-1), HSD activityGlycine maxL-aspartate-beta-semialdehydecosubstrate NADPH11.582.195.29pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 1 (GmAK-HSD-1), HSD activityGlycine maxNAD^+—24.90.281pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 1 (GmAK-HSD-1), HSD activityGlycine maxNADH—0.21390.61pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 1 (GmAK-HSD-1), HSD activityGlycine maxNADP^+—0.2350.18pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 1 (GmAK-HSD-1), HSD activityGlycine maxNADPH—0.0391296.2pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 2 (GmAK-HSD-2), HSD activityGlycine maxhomoserinecosubstrate NAD^+10.1513.40.757pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 2 (GmAK-HSD-2), HSD activityGlycine maxhomoserinecosubstrate NADP^+0.06570.690.0952pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 2 (GmAK-HSD-2), HSD activityGlycine maxL-aspartate-beta-semialdehydecosubstrate NADH22.580.84526.73pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 2 (GmAK-HSD-2), HSD activityGlycine maxL-aspartate-beta-semialdehydecosubstrate NADPH12.981.2510.39pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 2 (GmAK-HSD-2), HSD activityGlycine maxNAD^+—24.10.421pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 2 (GmAK-HSD-2), HSD activityGlycine maxNADH—0.19118.9pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 2 (GmAK-HSD-2), HSD activityGlycine maxNADP^+—0.2450.268pH 8, 25 °CPMID 19897476Open
bifunctional aspartate kinase-homoserine dehydrogenase 2 (GmAK-HSD-2), HSD activityGlycine maxNADPH—0.0392331.2pH 8, 25 °CPMID 19897476Open
homoserine dehydrogenaseSaccharomyces cerevisiae(L)-aspartate-beta-semialdehyde1260.22573pH 7.5, 37 °CPMID 28631755Open
homoserine dehydrogenase (BsHSD)Bacillus subtilisL-homoserine1.0735.080.03pH 9, 25 °CPMID 33046675Open
homoserine dehydrogenase (BsHSD)Bacillus subtilisnicotinamide adenine dinucleotide phosphate (oxidized)1.10.392.86pH 9, 25 °CPMID 33046675Open
homoserine dehydrogenase (HseDH)Pyrococcus horikoshiihomoserine—6.1—pH 11, 50 °CPMID 26154028Open
homoserine dehydrogenase (HseDH)Pyrococcus horikoshiiNAD70.10.32219pH 11, 50 °CPMID 26154028Open
homoserine dehydrogenase (HseDH)Pyrococcus horikoshiiNADH—0.019—pH 7.5, 50 °CPMID 26154028Open
homoserine dehydrogenase (HseDH)Pyrococcus horikoshiiNADPH—0.015—pH 7.5, 50 °CPMID 26154028Open
homoserine dehydrogenase (HseDH)variant K57APyrococcus horikoshiiNAD48.50.051.02 × 10³pH 11, 50 °CPMID 26154028Open
homoserine dehydrogenase (HseDH)variant K57APyrococcus horikoshiiNADP26.70.06518pH 11, 50 °CPMID 26154028Open
homoserine dehydrogenase (HseDH)variant R40APyrococcus horikoshiiNAD96.10.95102pH 11, 50 °CPMID 26154028Open
homoserine dehydrogenase (HseDH)variant R40APyrococcus horikoshiiNADP3.40.0489.1pH 11, 50 °CPMID 26154028Open
homoserine dehydrogenase IEscherichia coliD,L-aspartic β-semialdehyde—0.24—pH 7.5, 37 °CPMID 11368768Open
homoserine dehydrogenase IEscherichia colihomoserine—3.39—pH 7.5, 37 °CPMID 11368768Open
homoserine dehydrogenase IEscherichia coliNADP+—0.067—pH 7.5, 37 °CPMID 11368768Open
homoserine dehydrogenase IEscherichia coliNADPH—0.037—pH 7.5, 37 °CPMID 11368768Open
homoserine dehydrogenase, monofunctional (GmHSD)Glycine maxhomoserinecosubstrate NAD^+1.4317.40.0822pH 8, 25 °CPMID 19897476Open
homoserine dehydrogenase, monofunctional (GmHSD)Glycine maxhomoserinecosubstrate NADP^+0.07030.2750.256pH 8, 25 °CPMID 19897476Open
homoserine dehydrogenase, monofunctional (GmHSD)Glycine maxL-aspartate-beta-semialdehydecosubstrate NADH9.680.56917.02pH 8, 25 °CPMID 19897476Open
homoserine dehydrogenase, monofunctional (GmHSD)Glycine maxL-aspartate-beta-semialdehydecosubstrate NADPH2.80.098128.54pH 8, 25 °CPMID 19897476Open
homoserine dehydrogenase, monofunctional (GmHSD)Glycine maxNAD^+—2.70.53pH 8, 25 °CPMID 19897476Open
homoserine dehydrogenase, monofunctional (GmHSD)Glycine maxNADH—0.15861.29pH 8, 25 °CPMID 19897476Open
homoserine dehydrogenase, monofunctional (GmHSD)Glycine maxNADP^+—0.0342.07pH 8, 25 °CPMID 19897476Open
homoserine dehydrogenase, monofunctional (GmHSD)Glycine maxNADPH—0.0276101.4pH 8, 25 °CPMID 19897476Open