CatLogenzyme kinetics catalog

EC 1.1.1.34: hydroxymethylglutaryl-CoA reductase (NADPH)

OxidoreductasesOpen in Browse

CatLog read 29 records for EC 1.1.1.34 from 3 papers, for 3 organisms. Names in these papers: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, acetoacetyl-CoA thiolase/HMG-CoA reductase (mvaE gene product), HMG-CoA reductase activity, HMG-CoA reductase.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 75 records for EC 1.1.1.34 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.34 in Browse.

Papers

PaperOrganismsRecords
3-Hydroxy-3-methylglutaryl-coenzyme A reductase of Haloferax volcanii: role of histidine 398 and attenuation of activity by introduction of negative charge at position 404Haloferax volcanii17
Enterococcus faecalis acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, a dual-function protein of isopentenyl diphosphate biosynthesisEnterococcus faecalis10
Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductaseLeishmania major2

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
3-hydroxy-3-methylglutaryl-coenzyme A reductaseHaloferax volcanii(S)-3-hydroxy-3-methylglutaryl-coenzyme A—0.06—PMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductaseHaloferax volcaniiNADPHreaction [1]; initiated with (S)-HMG-CoA—0.066—PMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductaseHaloferax volcaniiNADPHreaction [2]; reduction of (R,S)-mevaldehyde to mevalonate—0.032—PMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant 404DHaloferax volcanii(R,S)-3-hydroxy-3-methylglutaryl-coenzyme A—2—pH 7.3, 37 °CPMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant 404DHaloferax volcaniiNADPH—0.16—pH 7.3, 37 °CPMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant 404D/H398QHaloferax volcanii(R,S)-3-hydroxy-3-methylglutaryl-coenzyme A—0.083—pH 7.3, 37 °CPMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant 404D/H398QHaloferax volcaniimevaldehyde—2.1—PMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant 404D/H398QHaloferax volcaniiNADPH—0.068—pH 7.3, 37 °CPMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant 404D/H398QHaloferax volcaniiNADPH—0.084—PMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant 404NHaloferax volcanii(S)-3-hydroxy-3-methylglutaryl-coenzyme A—0.077—PMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant 404NHaloferax volcaniimevaldehyde—4.2—PMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant 404NHaloferax volcaniiNADPHreaction [1]; initiated with (S)-HMG-CoA—0.072—PMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant 404NHaloferax volcaniiNADPHreaction [2]; reduction of (R,S)-mevaldehyde to mevalonate—0.031—PMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H398QHaloferax volcanii(R,S)-3-hydroxy-3-methylglutaryl-coenzyme A—0.2—pH 7.3, 37 °CPMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H398QHaloferax volcaniimevaldehyde—3—PMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H398QHaloferax volcaniiNADPH—0.177—pH 7.3, 37 °CPMID 9007988Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H398QHaloferax volcaniiNADPH—0.1—PMID 9007988Open
acetoacetyl-CoA thiolase/HMG-CoA reductase (mvaE gene product), HMG-CoA reductase activityEnterococcus faecalis3-hydroxy-3-methylglutaryl-coenzyme A—0.02—pH 6.5, 37 °CPMID 11914342Open
acetoacetyl-CoA thiolase/HMG-CoA reductase (mvaE gene product), HMG-CoA reductase activityEnterococcus faecaliscoenzyme Areaction 5; oxidative acylation of mevaldehyde to HMG-CoA—0.22—37 °CPMID 11914342Open
acetoacetyl-CoA thiolase/HMG-CoA reductase (mvaE gene product), HMG-CoA reductase activityEnterococcus faecaliscoenzyme Areaction 6; oxidative acylation of mevalonate to HMG-CoA—0.23—37 °CPMID 11914342Open
acetoacetyl-CoA thiolase/HMG-CoA reductase (mvaE gene product), HMG-CoA reductase activityEnterococcus faecalismevaldehyde—3.8—pH 7, 37 °CPMID 11914342Open
acetoacetyl-CoA thiolase/HMG-CoA reductase (mvaE gene product), HMG-CoA reductase activityEnterococcus faecalismevaldehyde—0.66—37 °CPMID 11914342Open
acetoacetyl-CoA thiolase/HMG-CoA reductase (mvaE gene product), HMG-CoA reductase activityEnterococcus faecalismevalonate—1—37 °CPMID 11914342Open
acetoacetyl-CoA thiolase/HMG-CoA reductase (mvaE gene product), HMG-CoA reductase activityEnterococcus faecalisNADP+reaction 5; oxidative acylation of mevaldehyde to HMG-CoA—0.67—37 °CPMID 11914342Open
acetoacetyl-CoA thiolase/HMG-CoA reductase (mvaE gene product), HMG-CoA reductase activityEnterococcus faecalisNADP+reaction 6; oxidative acylation of mevalonate to HMG-CoA—0.25—37 °CPMID 11914342Open
acetoacetyl-CoA thiolase/HMG-CoA reductase (mvaE gene product), HMG-CoA reductase activityEnterococcus faecalisNADPH—0.03—pH 6.5, 37 °CPMID 11914342Open
acetoacetyl-CoA thiolase/HMG-CoA reductase (mvaE gene product), HMG-CoA reductase activityEnterococcus faecalisNADPH—0.25—pH 7, 37 °CPMID 11914342Open
HMG-CoA reductaseLeishmania major(R,S)-3-hydroxy-3-methylglutaryl-CoA—0.0403—pH 6.75PMID 10861207Open
HMG-CoA reductaseLeishmania majorNADPH—0.0814—pH 6.75PMID 10861207Open