EC 1.1.1.87: homoisocitrate dehydrogenase
OxidoreductasesOpen in Browse
CatLog read 35 records for EC 1.1.1.87 from 4 papers, for 4 organisms. Names in these papers: homoisocitrate dehydrogenase (TtHICDH), TK0280 beta-decarboxylating dehydrogenase, isocitrate-homoisocitrate dehydrogenase (PH1722), Saci_2375 (isocitrate-homoisocitrate dehydrogenase).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 13 records for EC 1.1.1.87 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.87 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Enhancement of the latent 3-isopropylmalate dehydrogenase activity of promiscuous homoisocitrate dehydrogenase by directed evolution | Thermus thermophilus | 25 |
| Structure and function of an ancestral-type β-decarboxylating dehydrogenase from Thermococcus kodakarensis | Thermococcus kodakarensis | 4 |
| Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase | Pyrococcus horikoshii | 3 |
| Characterization of two β-decarboxylating dehydrogenases from Sulfolobus acidocaldarius | Sulfolobus acidocaldarius | 3 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| homoisocitrate dehydrogenase (TtHICDH) | Thermus thermophilus | 3-isopropylmalate | 0.08 | 1 | 0.075 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH), 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH) | Thermus thermophilus | NAD+ | — | 1.9 | 0.041 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH), NAD+ |
| homoisocitrate dehydrogenase (TtHICDH)variant 2ScHICDH | Thermus thermophilus | 3-isopropylmalate | 0.4 | 2.6 | 0.16 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant 2ScHICDH, 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH)variant 2ScHICDH | Thermus thermophilus | 3-isopropylmalate | 3.8 | — | — | pH 8, 60 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant 2ScHICDH, 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH)variant 2ScHICDH | Thermus thermophilus | NAD+ | — | 1.7 | 0.23 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant 2ScHICDH, NAD+ |
| homoisocitrate dehydrogenase (TtHICDH)variant 2ScM208T | Thermus thermophilus | 3-isopropylmalate | 0.3 | 1.4 | 0.22 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant 2ScM208T, 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH)variant 2ScM208T | Thermus thermophilus | NAD+ | — | 0.41 | 0.73 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant 2ScM208T, NAD+ |
| homoisocitrate dehydrogenase (TtHICDH)variant 2ScS72I | Thermus thermophilus | 3-isopropylmalate | 0.3 | 2.4 | 0.11 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant 2ScS72I, 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH)variant 2ScS72I | Thermus thermophilus | NAD+ | — | 1.5 | 0.17 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant 2ScS72I, NAD+ |
| homoisocitrate dehydrogenase (TtHICDH)variant 2ScV85M | Thermus thermophilus | 3-isopropylmalate | 0.4 | 1.4 | 0.14 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant 2ScV85M, 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH)variant 2ScV85M | Thermus thermophilus | NAD+ | — | 0.92 | 0.22 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant 2ScV85M, NAD+ |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-1 | Thermus thermophilus | 3-isopropylmalate | 2.9 | 0.59 | 4.9 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-1, 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-1 | Thermus thermophilus | 3-isopropylmalate | 24 | — | — | pH 8, 60 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-1, 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-1 | Thermus thermophilus | NAD+ | — | 1.2 | 2.5 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-1, NAD+ |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-1/Y15H | Thermus thermophilus | 3-isopropylmalate | 5.1 | 0.9 | 5.4 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-1/Y15H, 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-1/Y15H | Thermus thermophilus | 3-isopropylmalate | 46 | — | — | pH 8, 60 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-1/Y15H, 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-1/Y15H | Thermus thermophilus | NAD+ | — | 1.2 | 4.2 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-1/Y15H, NAD+ |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-1/Y15H/M238V | Thermus thermophilus | 3-isopropylmalate | 1.8 | 1.9 | 0.94 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-1/Y15H/M238V, 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-1/Y15H/M238V | Thermus thermophilus | NAD+ | — | 1.7 | 1.1 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-1/Y15H/M238V, NAD+ |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-1/Y15H/M310R | Thermus thermophilus | 3-isopropylmalate | 0.6 | 1.5 | 0.4 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-1/Y15H/M310R, 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-1/Y15H/M310R | Thermus thermophilus | NAD+ | — | 1.6 | 0.38 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-1/Y15H/M310R, NAD+ |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-1/Y15H/V57E | Thermus thermophilus | 3-isopropylmalate | 1.6 | 1 | 1.6 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-1/Y15H/V57E, 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-1/Y15H/V57E | Thermus thermophilus | NAD+ | — | 1.6 | 1.4 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-1/Y15H/V57E, NAD+ |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-2/Y15H/Y217F | Thermus thermophilus | 3-isopropylmalate | 0.3 | 0.92 | 0.33 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-2/Y15H/Y217F, 3-isopropylmalate |
| homoisocitrate dehydrogenase (TtHICDH)variant LR5-2/Y15H/Y217F | Thermus thermophilus | NAD+ | — | 0.9 | 0.33 | pH 8, 37 °C | PMID 20735360 | Open record: homoisocitrate dehydrogenase (TtHICDH) variant LR5-2/Y15H/Y217F, NAD+ |
| isocitrate-homoisocitrate dehydrogenase (PH1722) | Pyrococcus horikoshii | (2R,3S)-homoisocitric acid | 13.7 | 0.0183 | 749 | pH 7.8, 70 °C | PMID 15845397 | Open record: isocitrate-homoisocitrate dehydrogenase (PH1722), (2R,3S)-homoisocitric acid |
| isocitrate-homoisocitrate dehydrogenase (PH1722) | Pyrococcus horikoshii | isocitrate | 14.8 | 0.0164 | 902 | pH 7.8, 70 °C | PMID 15845397 | Open record: isocitrate-homoisocitrate dehydrogenase (PH1722), isocitrate |
| isocitrate-homoisocitrate dehydrogenase (PH1722) | Pyrococcus horikoshii | NAD+ | 21.8 | 0.0771 | 283 | pH 7.8, 70 °C | PMID 15845397 | Open record: isocitrate-homoisocitrate dehydrogenase (PH1722), NAD+ |
| Saci_2375 (isocitrate-homoisocitrate dehydrogenase) | Sulfolobus acidocaldarius | homoisocitrate | 37 | 0.011 | 3.2 × 10³ | pH 8, 60 °C | PMID 27590116 | Open record: Saci_2375 (isocitrate-homoisocitrate dehydrogenase), homoisocitrate |
| Saci_2375 (isocitrate-homoisocitrate dehydrogenase) | Sulfolobus acidocaldarius | isocitrate | 61 | 0.027 | 2.3 × 10³ | pH 8, 60 °C | PMID 27590116 | Open record: Saci_2375 (isocitrate-homoisocitrate dehydrogenase), isocitrate |
| Saci_2375 (isocitrate-homoisocitrate dehydrogenase) | Sulfolobus acidocaldarius | NADP+ | — | 0.05 | — | pH 8, 60 °C | PMID 27590116 | Open record: Saci_2375 (isocitrate-homoisocitrate dehydrogenase), NADP+ |
| TK0280 beta-decarboxylating dehydrogenase | Thermococcus kodakarensis | D-malate | 0.099 | 4.5 | 0.022 | pH 8, 60 °C | PMID 27831491 | Open record: TK0280 beta-decarboxylating dehydrogenase, D-malate |
| TK0280 beta-decarboxylating dehydrogenase | Thermococcus kodakarensis | homoisocitrate | 12 | 0.064 | 190 | pH 8, 60 °C | PMID 27831491 | Open record: TK0280 beta-decarboxylating dehydrogenase, homoisocitrate |
| TK0280 beta-decarboxylating dehydrogenase | Thermococcus kodakarensis | NAD+ | — | 0.92 | 0.11 | pH 8, 60 °C | PMID 27831491 | Open record: TK0280 beta-decarboxylating dehydrogenase, NAD+ |
| TK0280 beta-decarboxylating dehydrogenase | Thermococcus kodakarensis | NADP+ | — | 7.6 | 1.6 | pH 8, 60 °C | PMID 27831491 | Open record: TK0280 beta-decarboxylating dehydrogenase, NADP+ |