CatLogenzyme kinetics catalog

EC 1.13.11.33: arachidonate 15-lipoxygenase

OxidoreductasesOpen in Browse

CatLog read 49 records for EC 1.13.11.33 from 8 papers, for 4 organisms. Names in these papers: 12/15-lipoxygenase, 15-lipoxygenase 1 (reticulocyte-type 15-LOX), human platelet 12-lipoxygenase (h12-LOX), human reticulocyte 15-lipoxygenase-1 (h15-LOX-1) and 7 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 34 records for EC 1.13.11.33 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.13.11.33 in Browse.

Papers

PaperOrganismsRecords
Enantioselective substrate specificity of 15-lipoxygenase 1Oryctolagus cuniculus10
Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channelsOryctolagus cuniculus10
Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric ModulatorsHomo sapiens7
Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1Homo sapiens6
Mammalian Arachidonic Acid 15-Lipoxygenases: Fed-Batch Fermentation, Enzyme Purification and Functional CharacterizationHomo sapiens, Mus musculus6
Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-LipoxygenasePseudomonas aeruginosa5
Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenasesHomo sapiens3
Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenasesHomo sapiens2

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
12/15-lipoxygenaseOryctolagus cuniculusdioxygen13.70.00522.63 × 10³pH 7.4PMID 17675410Open
12/15-lipoxygenaseOryctolagus cuniculuslinoleic acid——740pH 7.4PMID 17675410Open
12/15-lipoxygenasevariant L367EOryctolagus cuniculusdioxygen2.20.009240pH 7.4PMID 17675410Open
12/15-lipoxygenasevariant L367EOryctolagus cuniculuslinoleic acid——260pH 7.4PMID 17675410Open
12/15-lipoxygenasevariant L367FOryctolagus cuniculusdioxygen5.60.0401140pH 7.4PMID 17675410Open
12/15-lipoxygenasevariant L367FOryctolagus cuniculuslinoleic acid——730pH 7.4PMID 17675410Open
12/15-lipoxygenasevariant L367KOryctolagus cuniculusdioxygen0.30.00930pH 7.4PMID 17675410Open
12/15-lipoxygenasevariant L367KOryctolagus cuniculuslinoleic acid——80pH 7.4PMID 17675410Open
12/15-lipoxygenasevariant L367WOryctolagus cuniculusdioxygen4.40.007630pH 7.4PMID 17675410Open
12/15-lipoxygenasevariant L367WOryctolagus cuniculuslinoleic acid——480pH 7.4PMID 17675410Open
15-hLO-1 (human reticulocyte 15-lipoxygenase-1)Homo sapiens10,10,13,13-tetradeuterated arachidonic acid10.0028360 calc.pH 7.5, 25 °CPMID 18547056Open
15-hLO-1 (human reticulocyte 15-lipoxygenase-1)Homo sapiens10,10-dideuterated arachidonic acid9.260.00342.7 × 10³ calc.pH 7.5, 25 °CPMID 18547056Open
15-hLO-1 (human reticulocyte 15-lipoxygenase-1)Homo sapiensarachidonic acid9.930.00372.7 × 10³ calc.pH 7.5, 25 °CPMID 18547056Open
15-lipoxygenase 1 (reticulocyte-type 15-LOX)Oryctolagus cuniculus(5Z,8Z,11Z,14Z,16R)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid—0.0289—pH 7.4PMID 15595827Open
15-lipoxygenase 1 (reticulocyte-type 15-LOX)Oryctolagus cuniculus(5Z,8Z,11Z,14Z,16S)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid0.510.023621.6pH 7.4PMID 15595827Open
15-lipoxygenase 1 (reticulocyte-type 15-LOX)Oryctolagus cuniculus(5Z,8Z,11Z,14Z,17R)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid0.180.2930.7pH 7.4PMID 15595827Open
15-lipoxygenase 1 (reticulocyte-type 15-LOX)Oryctolagus cuniculus(5Z,8Z,11Z,14Z,17S)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid1.240.2365.2pH 7.4PMID 15595827Open
15-lipoxygenase 1 (reticulocyte-type 15-LOX)Oryctolagus cuniculusarachidonic acid8.160.003012.7 × 10³pH 7.4PMID 15595827Open
15-lipoxygenase 1 (reticulocyte-type 15-LOX)variant F353LOryctolagus cuniculus(5Z,8Z,11Z,14Z,16R)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid0.080.1360.6pH 7.4PMID 15595827Open
15-lipoxygenase 1 (reticulocyte-type 15-LOX)variant F353LOryctolagus cuniculus(5Z,8Z,11Z,14Z,16S)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid0.20.02278.8pH 7.4PMID 15595827Open
15-lipoxygenase 1 (reticulocyte-type 15-LOX)variant F353LOryctolagus cuniculus(5Z,8Z,11Z,14Z,17R)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid0.20.03685.4pH 7.4PMID 15595827Open
15-lipoxygenase 1 (reticulocyte-type 15-LOX)variant F353LOryctolagus cuniculus(5Z,8Z,11Z,14Z,17S)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid0.240.03137.6pH 7.4PMID 15595827Open
15-lipoxygenase 1 (reticulocyte-type 15-LOX)variant F353LOryctolagus cuniculusarachidonic acid6.020.0087691pH 7.4PMID 15595827Open
human ALOX15 (hALOX15), arachidonic acid 15-lipoxygenaseHomo sapiensarachidonic acid11.20.00841.33 × 10³pH 7.2PMID 42646335Open
human ALOX15 (hALOX15), arachidonic acid 15-lipoxygenaseHomo sapienslinoleic acid27.80.01032.7 × 10³pH 7.2PMID 42646335Open
human ALOX15B (hALOX15B), arachidonic acid 15-lipoxygenase BHomo sapiensarachidonic acid0.90.0043210pH 7.2PMID 42646335Open
human ALOX15B (hALOX15B), arachidonic acid 15-lipoxygenase BHomo sapienslinoleic acid0.90.019850pH 7.2PMID 42646335Open
human epithelial 15-lipoxygenase-2 (h15-LOX-2)Homo sapiens5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid20.05735pH 7.5, 25 °CPMID 33048542Open
human epithelial 15-lipoxygenase-2 (h15-LOX-2)Homo sapiens5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid2.10.02972pH 7.5, 25 °CPMID 33048542Open
human platelet 12-lipoxygenase (h12-LOX)Homo sapiens14S-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid0.220.0882.4pH 8PMID 32324389Open
human platelet 12-lipoxygenase (h12-LOX)Homo sapiens14S-hydroxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid0.170.210.8pH 8PMID 32324389Open
human platelet 12-lipoxygenase (h12-LOX)Homo sapiens5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid0.150.001150pH 8, 25 °CPMID 33048542Open
human platelet 12-lipoxygenase (h12-LOX)Homo sapiens5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid0.0880.001751pH 8, 25 °CPMID 33048542Open
human platelet 12-lipoxygenase (h12-LOX)Homo sapiensarachidonic acid189.5 × 10⁻⁴1.9 × 10⁴pH 8PMID 32324389Open
human platelet 12-lipoxygenase (h12-LOX)Homo sapiensdocosahexaenoic acid139 × 10⁻⁴1.4 × 10⁴pH 8PMID 32324389Open
human reticulocyte 15-lipoxygenase-1 (15-hLO-1, 12/15-LO)Homo sapiensarachidonic acid—0.005—PMID 18972057Open
human reticulocyte 15-lipoxygenase-1 (15-hLO-1, 12/15-LO)Homo sapienslinoleic acid—0.0062—pH 7.5PMID 18972057Open
human reticulocyte 15-lipoxygenase-1 (h15-LOX-1)Homo sapiens14S-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid20.018110pH 7.5PMID 32324389Open
human reticulocyte 15-lipoxygenase-1 (h15-LOX-1)Homo sapiens14S-hydroxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid0.570.01830pH 7.5PMID 32324389Open
human reticulocyte 15-lipoxygenase-1 (h15-LOX-1)Homo sapiens5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid1.80.0078230pH 7.5, 25 °CPMID 33048542Open
human reticulocyte 15-lipoxygenase-1 (h15-LOX-1)Homo sapiens5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid1.10.0049230pH 7.5, 25 °CPMID 33048542Open
human reticulocyte 15-lipoxygenase-1 (h15-LOX-1)Homo sapiensdocosahexaenoic acid2.40.0067360pH 7.5PMID 32324389Open
LoxA (15-lipoxygenase, 15p-LOX)Pseudomonas aeruginosaarachidonic acid1810.0121.6 × 10⁴pH 6.5, 22 °CPMID 27226387Open
LoxA (15-lipoxygenase, 15p-LOX)Pseudomonas aeruginosaarachidonic acid1570.0121.3 × 10⁴pH 7, 22 °CPMID 27226387Open
LoxA (15-lipoxygenase, 15p-LOX)Pseudomonas aeruginosaarachidonic acid860.0136.6 × 10³pH 7.5, 22 °CPMID 27226387Open
LoxA (15-lipoxygenase, 15p-LOX)Pseudomonas aeruginosalinoleic acid280.0073.8 × 10³pH 7, 22 °CPMID 27226387Open
LoxA (15-lipoxygenase, 15p-LOX)Pseudomonas aeruginosaperdeuterated linoleic acid (linoleic acid-d31)0.90.19pH 7, 22 °CPMID 27226387Open
mouse Alox15 (mAlox15), arachidonic acid lipoxygenaseMus musculusarachidonic acid7.20.00511.41 × 10³pH 7.2PMID 42646335Open
mouse Alox15 (mAlox15), arachidonic acid lipoxygenaseMus musculuslinoleic acid4.10.00311.32 × 10³pH 7.2PMID 42646335Open