CatLogenzyme kinetics catalog

EC 1.14.15.16: vitamin D3 24-hydroxylase

OxidoreductasesOpen in Browse

CatLog read 9 records for EC 1.14.15.16 from 1 paper, for 2 organisms. Names in these papers: CYP24A1.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 10 records for EC 1.14.15.16 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.14.15.16 in Browse.

Papers

PaperOrganismsRecords
Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and ratsHomo sapiens, Rattus norvegicus9

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
CYP24A1Homo sapiens1α,25-dihydroxyvitamin D30.00723.5 × 10⁻⁴20pH 7.4PMID 16617161Open
CYP24A1Rattus norvegicus1α,25-dihydroxyvitamin D30.00431.9 × 10⁻⁴23pH 7.4PMID 16617161Open
CYP24A1variant I500FRattus norvegicus1α,25-dihydroxyvitamin D30.00180.001141.7pH 7.4PMID 16617161Open
CYP24A1variant I500LRattus norvegicus1α,25-dihydroxyvitamin D38.3 × 10⁻⁴3 × 10⁻⁴2.8pH 7.4PMID 16617161Open
CYP24A1variant I500TRattus norvegicus1α,25-dihydroxyvitamin D30.0021.4 × 10⁻⁴15.3pH 7.4PMID 16617161Open
CYP24A1variant T416ARattus norvegicus1α,25-dihydroxyvitamin D30.00422.4 × 10⁻⁴20pH 7.4PMID 16617161Open
CYP24A1variant T416MRattus norvegicus1α,25-dihydroxyvitamin D30.00356.6 × 10⁻⁴5.3pH 7.4PMID 16617161Open
CYP24A1variant T416SRattus norvegicus1α,25-dihydroxyvitamin D30.0052.2 × 10⁻⁴23pH 7.4PMID 16617161Open
CYP24A1variant T416VRattus norvegicus1α,25-dihydroxyvitamin D30.0120.0010411.8pH 7.4PMID 16617161Open