CatLogenzyme kinetics catalog

EC 1.14.15.4: steroid 11beta-monooxygenase

OxidoreductasesOpen in Browse

CatLog read 8 records for EC 1.14.15.4 from 1 paper, for 1 organism. Names in these papers: CYP11B1.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 10 records for EC 1.14.15.4 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.14.15.4 in Browse.

Papers

PaperOrganismsRecords
Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesisHomo sapiens8

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
CYP11B1Homo sapiens11-deoxycorticosterone11β-hydroxylation of DOC to corticosterone (B)2.6830.0177152 calc.pH 7.5, 37 °CPMID 34485929Open
CYP11B1Homo sapiens11-deoxycorticosterone18-hydroxylation of DOC to 18-hydroxy DOC (18OH-DOC)0.13230.02026.55 calc.pH 7.5, 37 °CPMID 34485929Open
CYP11B1Homo sapiens11-deoxycorticosterone0.010830.04050.267 calc.pH 7.5, 37 °CPMID 34485929Open
CYP11B1Homo sapiens11-deoxycortisol11β-hydroxylation of DOF to cortisol (F)2.1570.028276.5 calc.pH 7.5, 37 °CPMID 34485929Open
CYP11B1Homo sapiens11-deoxycortisol0.003570.03870.0922 calc.pH 7.5, 37 °CPMID 34485929Open
CYP11B1variant W49R/L50N/L53N/W56R/L244N/W247NHomo sapiens11-deoxycorticosterone11β-hydroxylation of DOC to corticosterone (B)2.2120.00777285 calc.pH 7.5, 37 °CPMID 34485929Open
CYP11B1variant W49R/L50N/L53N/W56R/L244N/W247NHomo sapiens11-deoxycorticosterone18-hydroxylation of DOC to 18-hydroxy DOC (18OH-DOC)0.0960.0084211 calc.pH 7.5, 37 °CPMID 34485929Open
CYP11B1variant W49R/L50N/L53N/W56R/L244N/W247NHomo sapiens11-deoxycortisol1.5090.0105144 calc.pH 7.5, 37 °CPMID 34485929Open