CatLogenzyme kinetics catalog

Values CatLog read from this paper

Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis

PMID 34485929doi:10.1016/j.crstbi.2021.08.001Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 8 records (16 values) from this paper: CYP11B1 from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 8 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.

EC 1.14.15.4

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
CYP11B1Homo sapiens11-deoxycorticosterone11β-hydroxylation of DOC to corticosterone (B)2.6830.0177152 calc.pH 7.5, 37 °COpen
CYP11B1Homo sapiens11-deoxycorticosterone18-hydroxylation of DOC to 18-hydroxy DOC (18OH-DOC)0.13230.02026.55 calc.pH 7.5, 37 °COpen
CYP11B1Homo sapiens11-deoxycorticosterone0.010830.04050.267 calc.pH 7.5, 37 °COpen
CYP11B1Homo sapiens11-deoxycortisol11β-hydroxylation of DOF to cortisol (F)2.1570.028276.5 calc.pH 7.5, 37 °COpen
CYP11B1Homo sapiens11-deoxycortisol0.003570.03870.0922 calc.pH 7.5, 37 °COpen
CYP11B1variant W49R/L50N/L53N/W56R/L244N/W247NHomo sapiens11-deoxycorticosterone11β-hydroxylation of DOC to corticosterone (B)2.2120.00777285 calc.pH 7.5, 37 °COpen
CYP11B1variant W49R/L50N/L53N/W56R/L244N/W247NHomo sapiens11-deoxycorticosterone18-hydroxylation of DOC to 18-hydroxy DOC (18OH-DOC)0.0960.0084211 calc.pH 7.5, 37 °COpen
CYP11B1variant W49R/L50N/L53N/W56R/L244N/W247NHomo sapiens11-deoxycortisol1.5090.0105144 calc.pH 7.5, 37 °COpen