EC 1.2.1.11: aspartate-semialdehyde dehydrogenase
OxidoreductasesOpen in Browse
CatLog read 71 records for EC 1.2.1.11 from 6 papers, for 7 organisms. Names in these papers: aspartate-beta-semialdehyde dehydrogenase, aspartate semialdehyde dehydrogenase, L-aspartate-beta-semialdehyde dehydrogenase (ecASADH), aspartate-beta-semialdehyde dehydrogenase (ASD) and 5 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 66 records for EC 1.2.1.11 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.2.1.11 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid | Bacillus subtilis, Escherichia coli and 1 more | 23 |
| Use of structural comparisons to select mutagenic targets in aspartate-beta-semialdehyde dehydrogenase | Escherichia coli | 20 |
| Expression and purification of aspartate beta-semialdehyde dehydrogenase from infectious microorganisms | Haemophilus influenzae, Pseudomonas aeruginosa and 1 more | 12 |
| An integrated study of threonine-pathway enzyme kinetics in Escherichia coli | Escherichia coli | 6 |
| Mutagenesis of Key Residues in the Binding Center of l-Aspartate-b-Semialdehyde Dehydrogenase from Escherichia coli Enhances Utilization of the Cofactor NAD(H) | Escherichia coli | 6 |
| Cloning and characterization of aspartate-beta-semialdehyde dehydrogenase from Mycobacterium tuberculosis H37 Rv | Mycobacterium tuberculosis | 4 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| aspartate semialdehyde dehydrogenase | Bacillus subtilis | 4-phospho-(L)-aspartate | 14.45 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase, 4-phospho-(L)-aspartate |
| aspartate semialdehyde dehydrogenase | Bacillus subtilis | 4-phospho-(L)-malate | 0.04 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase, 4-phospho-(L)-malate |
| aspartate semialdehyde dehydrogenasevariant E218C | Bacillus subtilis | 4-phospho-(L)-aspartate | 0.13 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase variant E218C, 4-phospho-(L)-aspartate |
| aspartate semialdehyde dehydrogenasevariant E218C | Bacillus subtilis | 4-phospho-(L)-malate | 0.07 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase variant E218C, 4-phospho-(L)-malate |
| aspartate semialdehyde dehydrogenasevariant E218Q | Bacillus subtilis | 4-phospho-(L)-aspartate | 0.15 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase variant E218Q, 4-phospho-(L)-aspartate |
| aspartate semialdehyde dehydrogenasevariant E218Q | Bacillus subtilis | 4-phospho-(L)-malate | 0.31 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase variant E218Q, 4-phospho-(L)-malate |
| aspartate semialdehyde dehydrogenase | Escherichia coli | 4-phospho-(L)-aspartate | 36.2 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase, 4-phospho-(L)-aspartate |
| aspartate semialdehyde dehydrogenase | Escherichia coli | 4-phospho-(L)-malate | 0.13 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase, 4-phospho-(L)-malate |
| aspartate semialdehyde dehydrogenase | Escherichia coli | D,L-aspartic β-semialdehyde | — | 0.11 | — | pH 7.5, 37 °C | PMID 11368768 | Open record: aspartate semialdehyde dehydrogenase, D,L-aspartic β-semialdehyde |
| aspartate semialdehyde dehydrogenase | Escherichia coli | NADP+Pi (not arsenate); cosubstrate ASA, Pi | — | 0.144 | — | pH 7.5, 37 °C | PMID 11368768 | Open record: aspartate semialdehyde dehydrogenase, NADP+ |
| aspartate semialdehyde dehydrogenase | Escherichia coli | NADP+cosubstrate ASA, arsenate | — | 0.13 | — | pH 7.5, 37 °C | PMID 11368768 | Open record: aspartate semialdehyde dehydrogenase, NADP+ |
| aspartate semialdehyde dehydrogenase | Escherichia coli | NADPH | — | 0.029 | — | pH 7.5, 37 °C | PMID 11368768 | Open record: aspartate semialdehyde dehydrogenase, NADPH |
| aspartate semialdehyde dehydrogenase | Escherichia coli | phosphate | — | 10.2 | — | pH 7.5, 37 °C | PMID 11368768 | Open record: aspartate semialdehyde dehydrogenase, phosphate |
| aspartate semialdehyde dehydrogenase | Escherichia coli | β-aspartyl phosphate | — | 0.022 | — | pH 7.5, 37 °C | PMID 11368768 | Open record: aspartate semialdehyde dehydrogenase, β-aspartyl phosphate |
| aspartate semialdehyde dehydrogenasevariant E241C | Escherichia coli | 4-phospho-(L)-aspartate | 0.15 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase variant E241C, 4-phospho-(L)-aspartate |
| aspartate semialdehyde dehydrogenasevariant E241C | Escherichia coli | 4-phospho-(L)-malate | 0.01 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase variant E241C, 4-phospho-(L)-malate |
| aspartate semialdehyde dehydrogenasevariant E241Q | Escherichia coli | 4-phospho-(L)-aspartate | 0.33 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase variant E241Q, 4-phospho-(L)-aspartate |
| aspartate semialdehyde dehydrogenasevariant E241Q | Escherichia coli | 4-phospho-(L)-malate | 0.08 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase variant E241Q, 4-phospho-(L)-malate |
| aspartate semialdehyde dehydrogenase | Methanocaldococcus jannaschii | 4-phospho-(L)-aspartate | 0.38 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase, 4-phospho-(L)-aspartate |
| aspartate semialdehyde dehydrogenase | Methanocaldococcus jannaschii | 4-phospho-(L)-malate | 0.04 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase, 4-phospho-(L)-malate |
| aspartate semialdehyde dehydrogenasevariant E210C | Methanocaldococcus jannaschii | 4-phospho-(L)-aspartate | 0.09 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase variant E210C, 4-phospho-(L)-aspartate |
| aspartate semialdehyde dehydrogenasevariant E210C | Methanocaldococcus jannaschii | 4-phospho-(L)-malate | 0.11 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase variant E210C, 4-phospho-(L)-malate |
| aspartate semialdehyde dehydrogenasevariant E210Q | Methanocaldococcus jannaschii | 4-phospho-(L)-aspartate | 0.09 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase variant E210Q, 4-phospho-(L)-aspartate |
| aspartate semialdehyde dehydrogenasevariant E210Q | Methanocaldococcus jannaschii | 4-phospho-(L)-malate | 0.08 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase variant E210Q, 4-phospho-(L)-malate |
| aspartate semialdehyde dehydrogenase (Bs-Asd) | Bacillus subtilis | aspartyl-4-phosphate | 14.5 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase (Bs-Asd), aspartyl-4-phosphate |
| aspartate semialdehyde dehydrogenase (Bs-Asd)variant E218Q | Bacillus subtilis | malyl-4-phosphate | 0.31 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase (Bs-Asd) variant E218Q, malyl-4-phosphate |
| aspartate semialdehyde dehydrogenase (Ec-Asd) | Escherichia coli | aspartyl-4-phosphate | 36 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase (Ec-Asd), aspartyl-4-phosphate |
| aspartate semialdehyde dehydrogenase (Ec-Asd) | Escherichia coli | malyl-4-phosphate | 0.13 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase (Ec-Asd), malyl-4-phosphate |
| aspartate semialdehyde dehydrogenase (Mj-Asd) | Methanocaldococcus jannaschii | aspartyl-4-phosphate | 0.38 | — | — | pH 7, 37 °C | PMID 28631755 | Open record: aspartate semialdehyde dehydrogenase (Mj-Asd), aspartyl-4-phosphate |
| aspartate-beta-semialdehyde dehydrogenase | Escherichia coli | L-aspartate-beta-semialdehyde | 610 | 0.17 | 3.6 × 10³ | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase, L-aspartate-beta-semialdehyde |
| aspartate-beta-semialdehyde dehydrogenase | Escherichia coli | NAD+ | 4.8 | 12 | 0.39 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase, NAD+ |
| aspartate-beta-semialdehyde dehydrogenase | Escherichia coli | NADP+ | 680 | 0.19 | 3.6 × 10³ | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase, NADP+ |
| aspartate-beta-semialdehyde dehydrogenase | Escherichia coli | phosphate | — | 4.8 | 130 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase, phosphate |
| aspartate-beta-semialdehyde dehydrogenasevariant Q162H | Escherichia coli | L-aspartate-beta-semialdehyde | 177 | 0.25 | 710 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant Q162H, L-aspartate-beta-semialdehyde |
| aspartate-beta-semialdehyde dehydrogenasevariant Q162H | Escherichia coli | phosphate | — | 4.7 | 38 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant Q162H, phosphate |
| aspartate-beta-semialdehyde dehydrogenasevariant Q162N | Escherichia coli | L-aspartate-beta-semialdehyde | 47 | 0.15 | 310 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant Q162N, L-aspartate-beta-semialdehyde |
| aspartate-beta-semialdehyde dehydrogenasevariant Q162N | Escherichia coli | NAD+ | 0.53 | 14 | 0.038 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant Q162N, NAD+ |
| aspartate-beta-semialdehyde dehydrogenasevariant Q162N | Escherichia coli | NADP+ | 55 | 0.21 | 260 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant Q162N, NADP+ |
| aspartate-beta-semialdehyde dehydrogenasevariant Q162N | Escherichia coli | phosphate | — | 4.6 | 10 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant Q162N, phosphate |
| aspartate-beta-semialdehyde dehydrogenasevariant Q39D | Escherichia coli | L-aspartate-beta-semialdehyde | 290 | 0.13 | 2.3 × 10³ | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant Q39D, L-aspartate-beta-semialdehyde |
| aspartate-beta-semialdehyde dehydrogenasevariant Q39D | Escherichia coli | NAD+ | 19 | 25 | 0.76 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant Q39D, NAD+ |
| aspartate-beta-semialdehyde dehydrogenasevariant Q39D | Escherichia coli | NADP+ | 270 | 1.7 | 160 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant Q39D, NADP+ |
| aspartate-beta-semialdehyde dehydrogenasevariant Q39D | Escherichia coli | phosphate | — | 4.7 | 62 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant Q39D, phosphate |
| aspartate-beta-semialdehyde dehydrogenasevariant R267L | Escherichia coli | L-aspartate-beta-semialdehyde | 58 | 5.3 | 11 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant R267L, L-aspartate-beta-semialdehyde |
| aspartate-beta-semialdehyde dehydrogenasevariant R267L | Escherichia coli | phosphate | — | 19 | 3 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant R267L, phosphate |
| aspartate-beta-semialdehyde dehydrogenasevariant R31D/Q39D | Escherichia coli | NAD+ | 3.6 | 2.8 | 1.3 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant R31D/Q39D, NAD+ |
| aspartate-beta-semialdehyde dehydrogenasevariant R31D/Q39D | Escherichia coli | NADP+ | 270 | 1.4 | 190 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant R31D/Q39D, NADP+ |
| aspartate-beta-semialdehyde dehydrogenasevariant R31L | Escherichia coli | NAD+ | 14 | 9.5 | 1.5 | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant R31L, NAD+ |
| aspartate-beta-semialdehyde dehydrogenasevariant R31L | Escherichia coli | NADP+ | 890 | 0.23 | 3.9 × 10³ | pH 8.6, 25 °C | PMID 7756269 | Open record: aspartate-beta-semialdehyde dehydrogenase variant R31L, NADP+ |
| aspartate-beta-semialdehyde dehydrogenase | Haemophilus influenzae | inorganic phosphate | — | 1.6 | 210 | pH 9, 30 °C | PMID 12071715 | Open record: aspartate-beta-semialdehyde dehydrogenase, inorganic phosphate |
| aspartate-beta-semialdehyde dehydrogenase | Haemophilus influenzae | L-aspartate-beta-semialdehyde | 330 | 0.24 | 1.4 × 10³ | pH 9, 30 °C | PMID 12071715 | Open record: aspartate-beta-semialdehyde dehydrogenase, L-aspartate-beta-semialdehyde |
| aspartate-beta-semialdehyde dehydrogenase | Haemophilus influenzae | NADP+ | — | 0.15 | 2.2 × 10³ | pH 9, 30 °C | PMID 12071715 | Open record: aspartate-beta-semialdehyde dehydrogenase, NADP+ |
| aspartate-beta-semialdehyde dehydrogenase | Pseudomonas aeruginosa | inorganic phosphate | — | 1.5 | 110 | pH 9, 30 °C | PMID 12071715 | Open record: aspartate-beta-semialdehyde dehydrogenase, inorganic phosphate |
| aspartate-beta-semialdehyde dehydrogenase | Pseudomonas aeruginosa | L-aspartate-beta-semialdehyde | 160 | 0.12 | 1.3 × 10³ | pH 9, 30 °C | PMID 12071715 | Open record: aspartate-beta-semialdehyde dehydrogenase, L-aspartate-beta-semialdehyde |
| aspartate-beta-semialdehyde dehydrogenase | Pseudomonas aeruginosa | NADP+ | — | 0.13 | 1.6 × 10³ | pH 9, 30 °C | PMID 12071715 | Open record: aspartate-beta-semialdehyde dehydrogenase, NADP+ |
| aspartate-beta-semialdehyde dehydrogenase (ASD) | Mycobacterium tuberculosis | L-aspartate-beta-semialdehydeapparent Km; apparent kcat/Km | — | 0.955 | 8.89 | pH 9, 30 °C | PMID 15752328 | Open record: aspartate-beta-semialdehyde dehydrogenase (ASD), L-aspartate-beta-semialdehyde |
| aspartate-beta-semialdehyde dehydrogenase (ASD) | Mycobacterium tuberculosis | L-aspartate-beta-semialdehydekcat calculated from the enzyme concentration | 8.49 | — | — | pH 9, 30 °C | PMID 15752328 | Open record: aspartate-beta-semialdehyde dehydrogenase (ASD), L-aspartate-beta-semialdehyde |
| aspartate-beta-semialdehyde dehydrogenase (ASD) | Mycobacterium tuberculosis | NADP+ | — | 0.065 | 131 | pH 9, 30 °C | PMID 15752328 | Open record: aspartate-beta-semialdehyde dehydrogenase (ASD), NADP+ |
| aspartate-beta-semialdehyde dehydrogenase (ASD) | Mycobacterium tuberculosis | phosphate | — | 11.39 | 0.745 | pH 9, 30 °C | PMID 15752328 | Open record: aspartate-beta-semialdehyde dehydrogenase (ASD), phosphate |
| aspartate-beta-semialdehyde dehydrogenase I | Vibrio cholerae | inorganic phosphate | — | 1.1 | 110 | pH 9, 30 °C | PMID 12071715 | Open record: aspartate-beta-semialdehyde dehydrogenase I, inorganic phosphate |
| aspartate-beta-semialdehyde dehydrogenase I | Vibrio cholerae | L-aspartate-beta-semialdehyde | 120 | 0.19 | 630 | pH 9, 30 °C | PMID 12071715 | Open record: aspartate-beta-semialdehyde dehydrogenase I, L-aspartate-beta-semialdehyde |
| aspartate-beta-semialdehyde dehydrogenase I | Vibrio cholerae | NADP+ | — | 0.32 | 380 | pH 9, 30 °C | PMID 12071715 | Open record: aspartate-beta-semialdehyde dehydrogenase I, NADP+ |
| aspartate-beta-semialdehyde dehydrogenase II | Vibrio cholerae | inorganic phosphate | — | 22 | 3 | pH 9, 30 °C | PMID 12071715 | Open record: aspartate-beta-semialdehyde dehydrogenase II, inorganic phosphate |
| aspartate-beta-semialdehyde dehydrogenase II | Vibrio cholerae | L-aspartate-beta-semialdehyde | 58 | 0.16 | 360 | pH 9, 30 °C | PMID 12071715 | Open record: aspartate-beta-semialdehyde dehydrogenase II, L-aspartate-beta-semialdehyde |
| aspartate-beta-semialdehyde dehydrogenase II | Vibrio cholerae | NADP+ | — | 0.36 | 160 | pH 9, 30 °C | PMID 12071715 | Open record: aspartate-beta-semialdehyde dehydrogenase II, NADP+ |
| L-aspartate-beta-semialdehyde dehydrogenase (ecASADH) | Escherichia coli | NAD+ | 9.5 | 11.4 | 0.8 | pH 9, 30 °C | PMID 26662025 | Open record: L-aspartate-beta-semialdehyde dehydrogenase (ecASADH), NAD+ |
| L-aspartate-beta-semialdehyde dehydrogenase (ecASADH) | Escherichia coli | NADP+ | 258 | 0.2 | 1125 | pH 9, 30 °C | PMID 26662025 | Open record: L-aspartate-beta-semialdehyde dehydrogenase (ecASADH), NADP+ |
| L-aspartate-beta-semialdehyde dehydrogenase (ecASADH)variant Q350N | Escherichia coli | NAD+ | 86.2 | 2.5 | 35.1 | pH 9, 30 °C | PMID 26662025 | Open record: L-aspartate-beta-semialdehyde dehydrogenase (ecASADH) variant Q350N, NAD+ |
| L-aspartate-beta-semialdehyde dehydrogenase (ecASADH)variant Q350N | Escherichia coli | NADP+ | 53.4 | 0.0057 | 9613 | pH 9, 30 °C | PMID 26662025 | Open record: L-aspartate-beta-semialdehyde dehydrogenase (ecASADH) variant Q350N, NADP+ |
| L-aspartate-beta-semialdehyde dehydrogenase (ecASADH)variant Q350N/H171A | Escherichia coli | NAD+ | 115.2 | 2.2 | 53.3 | pH 9, 30 °C | PMID 26662025 | Open record: L-aspartate-beta-semialdehyde dehydrogenase (ecASADH) variant Q350N/H171A, NAD+ |
| L-aspartate-beta-semialdehyde dehydrogenase (ecASADH)variant Q350N/H171A | Escherichia coli | NADP+ | 13.4 | 0.0026 | 5136 | pH 9, 30 °C | PMID 26662025 | Open record: L-aspartate-beta-semialdehyde dehydrogenase (ecASADH) variant Q350N/H171A, NADP+ |