CatLogenzyme kinetics catalog

EC 1.21.99.3: thyroxine 5-deiodinase

OxidoreductasesOpen in Browse

CatLog read 19 records for EC 1.21.99.3 from 1 paper, for 1 organism. Names in these papers: type III iodothyronine deiodinase (D3).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 18 records for EC 1.21.99.3 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.21.99.3 in Browse.

Papers

PaperOrganismsRecords
Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preferenceHomo sapiens19

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
type III iodothyronine deiodinase (D3)Homo sapiens3,3',5-triiodothyronine0.3 mM DTT; recombinant human D3 expressed in COS-1 cells—3.1 × 10⁻⁶—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)Homo sapiens3,3',5-triiodothyronine1 mM DTT; recombinant human D3 expressed in COS-1 cells—3.6 × 10⁻⁶—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)Homo sapiens3,3',5-triiodothyronine3 mM DTT; recombinant human D3 expressed in COS-1 cells—4.8 × 10⁻⁶—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)Homo sapiens3,3',5-triiodothyronine10 mM DTT; recombinant human D3 expressed in COS-1 cells—6.6 × 10⁻⁶—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)Homo sapiens3,3',5-triiodothyronine1 mM DTT; native D3 in human placenta microsomes—2.8 × 10⁻⁶—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)Homo sapiens3,3',5-triiodothyronine3 mM DTT; native D3 in human placenta microsomes—3.4 × 10⁻⁶—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)Homo sapiens3,3',5-triiodothyronine10 mM DTT; native D3 in human placenta microsomes—4.1 × 10⁻⁶—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)Homo sapiensT40.3 mM DTT; recombinant human D3 expressed in COS-1 cells—4.3 × 10⁻⁶—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)Homo sapiensT41 mM DTT; recombinant human D3 expressed in COS-1 cells—5.6 × 10⁻⁶—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)Homo sapiensT43 mM DTT; recombinant human D3 expressed in COS-1 cells—3.5 × 10⁻⁶—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)Homo sapiensT410 mM DTT; recombinant human D3 expressed in COS-1 cells—4.1 × 10⁻⁶—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)Homo sapiensT410 mM DTT; native D3 in human placenta microsomes—8 × 10⁻⁶—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)variant SeC144CysHomo sapiens3,3',5-triiodothyronine0.3 mM DTT—4.2 × 10⁻⁶—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)variant SeC144CysHomo sapiens3,3',5-triiodothyronine1 mM DTT—1.5 × 10⁻⁵—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)variant SeC144CysHomo sapiens3,3',5-triiodothyronine3 mM DTT—3.1 × 10⁻⁵—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)variant SeC144CysHomo sapiens3,3',5-triiodothyronine10 mM DTT—3.3 × 10⁻⁵—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)variant SeC144CysHomo sapiensT41 mM DTT—2.65 × 10⁻⁴—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)variant SeC144CysHomo sapiensT43 mM DTT—4.77 × 10⁻⁴—pH 7.2, 37 °CPMID 12746313Open
type III iodothyronine deiodinase (D3)variant SeC144CysHomo sapiensT410 mM DTT—5.7 × 10⁻⁴—pH 7.2, 37 °CPMID 12746313Open