EC 1.5.1.12: 1-pyrroline-5-carboxylate dehydrogenase
OxidoreductasesOpen in Browse
CatLog read 31 records for EC 1.5.1.12 from 2 papers, for 2 organisms. Names in these papers: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), Δ1-pyrroline-5-carboxylate dehydrogenase (TcP5CDH).
EC 1.5.1.12 is no longer current; BRENDA: “transferred to EC 1.2.1.88”.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Purification and characterization of human liver "high Km" aldehyde dehydrogenase and its identification as glutamic gamma-semialdehyde dehydrogenase | Homo sapiens | 25 |
| Role of Δ1-pyrroline-5-carboxylate dehydrogenase supports mitochondrial metabolism and host-cell invasion of Trypanosoma cruzi | Trypanosoma cruzi | 6 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | 3-nitrobenzaldehyde | — | 2.4 | — | 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), 3-nitrobenzaldehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | 4-nitrobenzaldehyde | — | 11.9 | — | 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), 4-nitrobenzaldehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | 4-nitrophenyl acetate | — | 0.08 | — | pH 7 | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), 4-nitrophenyl acetate |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | acetaldehyde | — | 5 | — | pH 7, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), acetaldehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | acetaldehyde | — | 2.3 | — | pH 8.5, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), acetaldehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | adipic semialdehyde | — | 0.009 | — | pH 7, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), adipic semialdehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | adipic semialdehyde | — | 0.02 | — | pH 8.5, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), adipic semialdehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | DL-glutamate gamma-semialdehyde | — | 0.1 | — | pH 7, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), DL-glutamate gamma-semialdehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | DL-glutamate gamma-semialdehyde | — | 0.17 | — | pH 8.5, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), DL-glutamate gamma-semialdehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | glutaric semialdehyde | — | 0.014 | — | pH 7, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), glutaric semialdehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | glutaric semialdehyde | — | 0.044 | — | pH 8.5, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), glutaric semialdehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | nicotinamide adenine dinucleotideNAD varied 30-500 µM; 15 mM acetaldehyde | — | 0.041 | — | pH 7, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), nicotinamide adenine dinucleotide |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | nicotinamide adenine dinucleotideNAD varied 30-500 µM; 15 mM acetaldehyde | — | 0.015 | — | pH 8.5, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), nicotinamide adenine dinucleotide |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | nicotinamide adenine dinucleotideNAD varied 2-40 µM; 500 µM succinic semialdehyde | — | 0.01 | — | pH 7, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), nicotinamide adenine dinucleotide |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | nicotinamide adenine dinucleotideNAD varied 2-2100 µM; glutaric semialdehyde 35 µM | — | 0.03 | — | pH 7, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), nicotinamide adenine dinucleotide |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | nicotinamide adenine dinucleotideNAD varied 2-2100 µM; glutaric semialdehyde 66 µM | — | 0.014 | — | pH 8.5, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), nicotinamide adenine dinucleotide |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | nicotinamide adenine dinucleotideNAD varied 8-2000 µM; glutamic gamma-semialdehyde 100 µM | — | 0.087 | — | pH 7, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), nicotinamide adenine dinucleotide |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | nicotinamide adenine dinucleotideNAD varied 8-2000 µM; glutamic gamma-semialdehyde 270 µM | — | 0.14 | — | pH 8.5, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), nicotinamide adenine dinucleotide |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | nicotinamide adenine dinucleotide phosphate | — | 0.35 | — | pH 7, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), nicotinamide adenine dinucleotide phosphate |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | propionaldehyde | — | 9.4 | — | pH 7, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), propionaldehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | propionaldehyde | — | 18 | — | pH 8.5, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), propionaldehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | succinic semialdehyde500 µM NAD; Lineweaver-Burk; steady-state velocity | — | 0.01 | — | pH 7, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), succinic semialdehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | succinic semialdehyde39 µM NAD (below NAD substrate inhibition) | — | 0.024 | — | pH 7, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), succinic semialdehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | succinic semialdehyde | — | 0.024 | — | pH 8.5, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), succinic semialdehyde |
| glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) | Homo sapiens | succinic semialdehyde | — | 0.4 | — | pH 8.5, 25 °C | PMID 3944130 | Open record: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase), succinic semialdehyde |
| Δ1-pyrroline-5-carboxylate dehydrogenase (TcP5CDH) | Trypanosoma cruzi | L-glutamate gamma-semialdehydeMitochondrial lysate column | 130.7 | 0.043 | 3 × 10³ | pH 7.2, 28 °C | PMID 25623067 | Open record: Δ1-pyrroline-5-carboxylate dehydrogenase (TcP5CDH), L-glutamate gamma-semialdehyde |
| Δ1-pyrroline-5-carboxylate dehydrogenase (TcP5CDH) | Trypanosoma cruzi | L-glutamate gamma-semialdehydeTcP5CDH-His_6 column | 7 | 0.072 | 97 | pH 7.2, 28 °C | PMID 25623067 | Open record: Δ1-pyrroline-5-carboxylate dehydrogenase (TcP5CDH), L-glutamate gamma-semialdehyde |
| Δ1-pyrroline-5-carboxylate dehydrogenase (TcP5CDH) | Trypanosoma cruzi | NAD+Mitochondrial lysate column | 89.2 | 0.039 | 2.3 × 10³ | pH 7.2, 28 °C | PMID 25623067 | Open record: Δ1-pyrroline-5-carboxylate dehydrogenase (TcP5CDH), NAD+ |
| Δ1-pyrroline-5-carboxylate dehydrogenase (TcP5CDH) | Trypanosoma cruzi | NAD+TcP5CDH-His_6 column | 7.5 | 0.0723 | 103 | pH 7.2, 28 °C | PMID 25623067 | Open record: Δ1-pyrroline-5-carboxylate dehydrogenase (TcP5CDH), NAD+ |
| Δ1-pyrroline-5-carboxylate dehydrogenase (TcP5CDH) | Trypanosoma cruzi | NADP+Mitochondrial lysate column | 116.8 | 0.302 | 390 | pH 7.2, 28 °C | PMID 25623067 | Open record: Δ1-pyrroline-5-carboxylate dehydrogenase (TcP5CDH), NADP+ |
| Δ1-pyrroline-5-carboxylate dehydrogenase (TcP5CDH) | Trypanosoma cruzi | NADP+TcP5CDH-His_6 column | 1.2 | 0.342 | 3 | pH 7.2, 28 °C | PMID 25623067 | Open record: Δ1-pyrroline-5-carboxylate dehydrogenase (TcP5CDH), NADP+ |