CatLogenzyme kinetics catalog

Values CatLog read from this paper

Purification and characterization of human liver "high Km" aldehyde dehydrogenase and its identification as glutamic gamma-semialdehyde dehydrogenase

PMID 3944130doi:10.1016/s0021-9258(17)35911-2Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 25 records (25 values) from this paper: glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 1.5.1.12

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiens3-nitrobenzaldehyde—2.4—25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiens4-nitrobenzaldehyde—11.9—25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiens4-nitrophenyl acetate—0.08—pH 7Open
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensacetaldehyde—5—pH 7, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensacetaldehyde—2.3—pH 8.5, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensadipic semialdehyde—0.009—pH 7, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensadipic semialdehyde—0.02—pH 8.5, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensDL-glutamate gamma-semialdehyde—0.1—pH 7, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensDL-glutamate gamma-semialdehyde—0.17—pH 8.5, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensglutaric semialdehyde—0.014—pH 7, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensglutaric semialdehyde—0.044—pH 8.5, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensnicotinamide adenine dinucleotideNAD varied 30-500 µM; 15 mM acetaldehyde—0.041—pH 7, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensnicotinamide adenine dinucleotideNAD varied 30-500 µM; 15 mM acetaldehyde—0.015—pH 8.5, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensnicotinamide adenine dinucleotideNAD varied 2-40 µM; 500 µM succinic semialdehyde—0.01—pH 7, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensnicotinamide adenine dinucleotideNAD varied 2-2100 µM; glutaric semialdehyde 35 µM—0.03—pH 7, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensnicotinamide adenine dinucleotideNAD varied 2-2100 µM; glutaric semialdehyde 66 µM—0.014—pH 8.5, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensnicotinamide adenine dinucleotideNAD varied 8-2000 µM; glutamic gamma-semialdehyde 100 µM—0.087—pH 7, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensnicotinamide adenine dinucleotideNAD varied 8-2000 µM; glutamic gamma-semialdehyde 270 µM—0.14—pH 8.5, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapiensnicotinamide adenine dinucleotide phosphate—0.35—pH 7, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapienspropionaldehyde—9.4—pH 7, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapienspropionaldehyde—18—pH 8.5, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapienssuccinic semialdehyde500 µM NAD; Lineweaver-Burk; steady-state velocity—0.01—pH 7, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapienssuccinic semialdehyde39 µM NAD (below NAD substrate inhibition)—0.024—pH 7, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapienssuccinic semialdehyde—0.024—pH 8.5, 25 °COpen
glutamic gamma-semialdehyde dehydrogenase (1-pyrroline-5-carboxylate dehydrogenase; E4 'high Km' aldehyde dehydrogenase)Homo sapienssuccinic semialdehyde—0.4—pH 8.5, 25 °COpen