CatLogenzyme kinetics catalog

EC 1.5.1.33: pteridine reductase

OxidoreductasesOpen in Browse

CatLog read 40 records for EC 1.5.1.33 from 3 papers, for 4 organisms. Names in these papers: pteridine reductase 1 (PTR1), PruA, TbPTR1 (pteridine reductase 1), LmPTR1 (pteridine reductase 1).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 31 records for EC 1.5.1.33 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.5.1.33 in Browse.

Papers

PaperOrganismsRecords
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania majorLeishmania major, Leishmania tarentolae28
Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania majorLeishmania major, Trypanosoma brucei7
Enzymatic and Mutational Analysis of the PruA Pteridine Reductase Required for Pterin-Dependent Control of Biofilm Formation in Agrobacterium tumefaciensAgrobacterium tumefaciens5

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
LmPTR1 (pteridine reductase 1)Leishmania major7,8-dihydrobiopterin0.570.00332170pH 7.4, 25 °CPMID 21239486Open
LmPTR1 (pteridine reductase 1)Leishmania majorquinonoid 6,7-dimethyl-7,8-dihydropterin0.440.02121pH 7.4, 25 °CPMID 21239486Open
LmPTR1 (pteridine reductase 1)Leishmania majorquinonoid 7,8-dihydrobiopterin1.840.0103180pH 7.4, 25 °CPMID 21239486Open
PruAAgrobacterium tumefaciens7,8-D-dihydroneopterin2.40.095125pH 6PMID 32482721Open
PruAAgrobacterium tumefaciens7,8-L-dihydrobiopterin4.70.0347130pH 6PMID 32482721Open
PruAAgrobacterium tumefaciens7,8-L-dihydromonapterin2.30.071332pH 6PMID 32482721Open
PruAvariant Y161F/Y163FAgrobacterium tumefaciens7,8-L-dihydromonapterin20.33326pH 6PMID 32482721Open
PruAvariant Y163FAgrobacterium tumefaciens7,8-L-dihydromonapterin4.20.212720pH 6PMID 32482721Open
pteridine reductase 1 (PTR1)Leishmania majorBiopterinrecombinant; expressed in E. coli (pET-3a)—0.0122—pH 4.7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majorBiopterin—0.0198—pH 6, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majorBiopterin—0.0399—pH 7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majorBiopterinnative; purified from L. major ptr1-/+PTR1 promastigotes—0.0101—pH 4.7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majordihydrobiopterin—0.0076—pH 4.7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majordihydrobiopterin—0.0056—pH 6, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majordihydrobiopterin—0.0054—pH 7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majordihydrofolate—0.0061—pH 4.7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majordihydrofolate—0.0034—pH 6, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majordihydrofolate—0.0054—pH 7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majorFolate—0.0016—pH 4.7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majorFolaterecombinant; expressed in E. coli (pET-3a)—0.0026—pH 6, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majorFolate—0.0085—pH 7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majorFolatenative; purified from L. major ptr1-/+PTR1 promastigotes—0.0024—pH 6, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majorNADPHBiopterin; cosubstrate Biopterin; recombinant—0.0132—pH 4.7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majorNADPHH_2biopterin; cosubstrate H_2biopterin; recombinant—0.0145—pH 4.7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majorNADPHFolate fixed (Table I footnote 1-a); cosubstrate Folate—0.0122—pH 6, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majorNADPHH_2folate fixed (Table I footnote 1-a); recombinant—0.0142—pH 6, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majorNADPHBiopterin; cosubstrate Biopterin; native—0.0116—pH 4.7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania majorNADPHFolate fixed (Table I footnote 1-a); cosubstrate Folate—0.0135—pH 6, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania tarentolaeBiopterin—0.0109—pH 4.7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania tarentolaedihydrobiopterin—0.0085—pH 4.7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania tarentolaedihydrofolate—0.0067—pH 6, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania tarentolaeFolate—0.0019—pH 6, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania tarentolaeNADPHBiopterin; cosubstrate Biopterin—0.0123—pH 4.7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania tarentolaeNADPHH_2biopterin; cosubstrate H_2biopterin—0.00935—pH 4.7, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania tarentolaeNADPHFolate fixed (Table I footnote 1-a); cosubstrate Folate—0.0146—pH 6, 30 °CPMID 9153248Open
pteridine reductase 1 (PTR1)Leishmania tarentolaeNADPHH_2folate fixed (Table I footnote 1-a)—0.012—pH 6, 30 °CPMID 9153248Open
TbPTR1 (pteridine reductase 1)Trypanosoma brucei7,8-dihydrobiopterin0.052.94 × 10⁻⁵1.7 × 10³pH 7.4, 25 °CPMID 21239486Open
TbPTR1 (pteridine reductase 1)Trypanosoma bruceiNADPH—0.0017—pH 7.4, 25 °CPMID 21239486Open
TbPTR1 (pteridine reductase 1)Trypanosoma bruceiquinonoid 6,7-dimethyl-7,8-dihydropterin0.430.016626pH 7.4, 25 °CPMID 21239486Open
TbPTR1 (pteridine reductase 1)Trypanosoma bruceiquinonoid 7,8-dihydrobiopterin0.540.00336160pH 7.4, 25 °CPMID 21239486Open