EC 1.6.5.10: NADPH dehydrogenase (quinone)
OxidoreductasesOpen in Browse
CatLog read 35 records for EC 1.6.5.10 from 3 papers, for 2 organisms. Names in these papers: NfsA, carbonyl reductase 4 (CBR4), carbonyl reductase 3 (hCBR3).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 31 records for EC 1.6.5.10 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.6.5.10 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Residue Phe42 is critical for the catalytic activity of Escherichia coli major nitroreductase NfsA | Escherichia coli | 20 |
| Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase | Homo sapiens | 10 |
| Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1 | Homo sapiens | 5 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| carbonyl reductase 3 (hCBR3) | Homo sapiens | 4-benzoylpyridine | 0.0117 | 0.3 | 0.038 | pH 6.5, 25 °C | PMID 18493841 | Open record: carbonyl reductase 3 (hCBR3), 4-benzoylpyridine |
| carbonyl reductase 3 (hCBR3) | Homo sapiens | 4-nitrobenzaldehyde | 0.0098 | 0.13 | 0.075 | pH 6.5, 25 °C | PMID 18493841 | Open record: carbonyl reductase 3 (hCBR3), 4-nitrobenzaldehyde |
| carbonyl reductase 3 (hCBR3) | Homo sapiens | menadione (2-methyl-1,4-naphthoquinone) | 0.0092 | 0.043 | 0.22 | pH 6.5, 25 °C | PMID 18493841 | Open record: carbonyl reductase 3 (hCBR3), menadione (2-methyl-1,4-naphthoquinone) |
| carbonyl reductase 3 (hCBR3) | Homo sapiens | menadione (2-methyl-1,4-naphthoquinone) | 0.0712 | 0.0535 | 1.33 calc. | pH 7.4, 37 °C | PMID 18493841 | Open record: carbonyl reductase 3 (hCBR3), menadione (2-methyl-1,4-naphthoquinone) |
| carbonyl reductase 3 (hCBR3) | Homo sapiens | NADPH | — | 0.038 | — | pH 6.5, 25 °C | PMID 18493841 | Open record: carbonyl reductase 3 (hCBR3), NADPH |
| carbonyl reductase 4 (CBR4) | Homo sapiens | 1,2-naphthoquinone | 0.21 | 0.003 | 70 | pH 7.4, 25 °C | PMID 19000905 | Open record: carbonyl reductase 4 (CBR4), 1,2-naphthoquinone |
| carbonyl reductase 4 (CBR4) | Homo sapiens | 1,4-benzoquinone | 0.207 | 0.0019 | 108 | pH 7.4, 25 °C | PMID 19000905 | Open record: carbonyl reductase 4 (CBR4), 1,4-benzoquinone |
| carbonyl reductase 4 (CBR4) | Homo sapiens | 1,4-naphthoquinone | 0.195 | 0.0045 | 43 | pH 7.4, 25 °C | PMID 19000905 | Open record: carbonyl reductase 4 (CBR4), 1,4-naphthoquinone |
| carbonyl reductase 4 (CBR4) | Homo sapiens | 2,3-dimethoxy-5-methyl-1,4-benzoquinone | 0.068 | 0.0044 | 15.5 | pH 7.4, 25 °C | PMID 19000905 | Open record: carbonyl reductase 4 (CBR4), 2,3-dimethoxy-5-methyl-1,4-benzoquinone |
| carbonyl reductase 4 (CBR4) | Homo sapiens | 2-methyl-1,4-benzoquinone | 0.258 | 0.0065 | 40 | pH 7.4, 25 °C | PMID 19000905 | Open record: carbonyl reductase 4 (CBR4), 2-methyl-1,4-benzoquinone |
| carbonyl reductase 4 (CBR4) | Homo sapiens | 5-hydroxy-1,4-naphthoquinone | 0.19 | 0.003 | 63 | pH 7.4, 25 °C | PMID 19000905 | Open record: carbonyl reductase 4 (CBR4), 5-hydroxy-1,4-naphthoquinone |
| carbonyl reductase 4 (CBR4) | Homo sapiens | 5-hydroxy-2-methyl-1,4-naphthoquinone | 0.135 | 0.0043 | 32 | pH 7.4, 25 °C | PMID 19000905 | Open record: carbonyl reductase 4 (CBR4), 5-hydroxy-2-methyl-1,4-naphthoquinone |
| carbonyl reductase 4 (CBR4) | Homo sapiens | 9,10-phenanthrenequinone | 0.305 | 0.0016 | 180 | pH 7.4, 25 °C | PMID 19000905 | Open record: carbonyl reductase 4 (CBR4), 9,10-phenanthrenequinone |
| carbonyl reductase 4 (CBR4) | Homo sapiens | Menadione | 0.212 | 0.036 | 5.8 | pH 7.4, 25 °C | PMID 19000905 | Open record: carbonyl reductase 4 (CBR4), Menadione |
| carbonyl reductase 4 (CBR4) | Homo sapiens | NADPH | — | 0.011 | — | pH 7.4, 25 °C | PMID 19000905 | Open record: carbonyl reductase 4 (CBR4), NADPH |
| NfsA | Escherichia coli | 2,4,6-trinitrotoluene | 56.21 | 0.029 | 1.94 × 10³ | pH 7 | PMID 23801116 | Open record: NfsA, 2,4,6-trinitrotoluene |
| NfsA | Escherichia coli | 2,4-dinitrotoluene | 24.94 | 0.176 | 142 | pH 7 | PMID 23801116 | Open record: NfsA, 2,4-dinitrotoluene |
| NfsA | Escherichia coli | 5-(aziridin-1-yl)-2,4-dinitrobenzamide | 36.64 | 0.327 | 112 | pH 7 | PMID 23801116 | Open record: NfsA, 5-(aziridin-1-yl)-2,4-dinitrobenzamide |
| NfsA | Escherichia coli | NADPH | 16.3 | 0.085 | 192 | pH 7 | PMID 23801116 | Open record: NfsA, NADPH |
| NfsA | Escherichia coli | nitrofurazone | 19.37 | 0.012 | 1.61 × 10³ | pH 7 | PMID 23801116 | Open record: NfsA, nitrofurazone |
| NfsAvariant F42A | Escherichia coli | 2,4,6-trinitrotoluene | 0.67 | 0.013 | 50 | pH 7 | PMID 23801116 | Open record: NfsA variant F42A, 2,4,6-trinitrotoluene |
| NfsAvariant F42A | Escherichia coli | 2,4-dinitrotoluene | 0.7 | 0.366 | 2 | pH 7 | PMID 23801116 | Open record: NfsA variant F42A, 2,4-dinitrotoluene |
| NfsAvariant F42A | Escherichia coli | 5-(aziridin-1-yl)-2,4-dinitrobenzamide | 1.08 | 0.487 | 2 | pH 7 | PMID 23801116 | Open record: NfsA variant F42A, 5-(aziridin-1-yl)-2,4-dinitrobenzamide |
| NfsAvariant F42A | Escherichia coli | NADPH | 0.46 | 0.085 | 5 | pH 7 | PMID 23801116 | Open record: NfsA variant F42A, NADPH |
| NfsAvariant F42A | Escherichia coli | nitrofurazone | 0.8 | 0.064 | 10 | pH 7 | PMID 23801116 | Open record: NfsA variant F42A, nitrofurazone |
| NfsAvariant F42N | Escherichia coli | 2,4,6-trinitrotoluene | 4.95 | 0.02 | 250 | pH 7 | PMID 23801116 | Open record: NfsA variant F42N, 2,4,6-trinitrotoluene |
| NfsAvariant F42N | Escherichia coli | 2,4-dinitrotoluene | 3.64 | 0.313 | 12 | pH 7 | PMID 23801116 | Open record: NfsA variant F42N, 2,4-dinitrotoluene |
| NfsAvariant F42N | Escherichia coli | 5-(aziridin-1-yl)-2,4-dinitrobenzamide | 2.99 | 0.332 | 9 | pH 7 | PMID 23801116 | Open record: NfsA variant F42N, 5-(aziridin-1-yl)-2,4-dinitrobenzamide |
| NfsAvariant F42N | Escherichia coli | NADPH | 0.78 | 0.049 | 16 | pH 7 | PMID 23801116 | Open record: NfsA variant F42N, NADPH |
| NfsAvariant F42N | Escherichia coli | nitrofurazone | 1.82 | 0.023 | 80 | pH 7 | PMID 23801116 | Open record: NfsA variant F42N, nitrofurazone |
| NfsAvariant F42Y | Escherichia coli | 2,4,6-trinitrotoluene | 27.06 | 0.02 | 1.35 × 10³ | pH 7 | PMID 23801116 | Open record: NfsA variant F42Y, 2,4,6-trinitrotoluene |
| NfsAvariant F42Y | Escherichia coli | 2,4-dinitrotoluene | 17.31 | 0.206 | 84 | pH 7 | PMID 23801116 | Open record: NfsA variant F42Y, 2,4-dinitrotoluene |
| NfsAvariant F42Y | Escherichia coli | 5-(aziridin-1-yl)-2,4-dinitrobenzamide | 24.27 | 0.322 | 75 | pH 7 | PMID 23801116 | Open record: NfsA variant F42Y, 5-(aziridin-1-yl)-2,4-dinitrobenzamide |
| NfsAvariant F42Y | Escherichia coli | NADPH | 9.01 | 0.054 | 167 | pH 7 | PMID 23801116 | Open record: NfsA variant F42Y, NADPH |
| NfsAvariant F42Y | Escherichia coli | nitrofurazone | 15.73 | 0.022 | 720 | pH 7 | PMID 23801116 | Open record: NfsA variant F42Y, nitrofurazone |