EC 1.6.5.2: NAD(P)H dehydrogenase (quinone)

OxidoreductasesOpen in Browse

CatLog read 77 records for EC 1.6.5.2 from 7 papers, for 6 organisms. Names in these papers: NAD(P)H:acceptor oxidoreductase FerB, nitroreductase (NTR), LpdA, QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product) and 3 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 159 records for EC 1.6.5.2 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.6.5.2 in Browse.

Papers

Papers with records for EC 1.6.5.2
Paper	Organisms	Records
The structural and functional basis of catalysis mediated by NAD(P)H:acceptor Oxidoreductase (FerB) of Paracoccus denitrificans	Paracoccus denitrificans	21
Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme	Escherichia coli	18
Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis	Mycobacterium tuberculosis	12
Crystal structure of a new type of NADPH-dependent quinone oxidoreductase (QOR2) from Escherichia coli	Escherichia coli	10
WrbA from Escherichia coli and Archaeoglobus fulgidus is an NAD(P)H:quinone oxidoreductase	Archaeoglobus fulgidus, Escherichia coli	6
Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry	Homo sapiens	6
Molecular cloning and characterization of an NADPH quinone oxidoreductase from Kluyveromyces marxianus	Kluyveromyces marxianus	4

Records

Records for EC 1.6.5.2 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
LpdA	Mycobacterium tuberculosis	2,6-dimethyl-1,4-benzoquinonecosubstrate NADH	—	0.011	250	pH 7.5, 25 °C	PMID 15456792	Open record: LpdA, 2,6-dimethyl-1,4-benzoquinone
LpdA	Mycobacterium tuberculosis	2,6-dimethyl-1,4-benzoquinonecosubstrate NADPH	—	0.0016	4.9	pH 7.5, 25 °C	PMID 15456792	Open record: LpdA, 2,6-dimethyl-1,4-benzoquinone
LpdA	Mycobacterium tuberculosis	5-hydroxy-1,4-naphthaquinonecosubstrate NADH	—	0.0055	450	pH 7.5, 25 °C	PMID 15456792	Open record: LpdA, 5-hydroxy-1,4-naphthaquinone
LpdA	Mycobacterium tuberculosis	5-hydroxy-1,4-naphthaquinonecosubstrate NADPH	—	3.9 × 10⁻⁴	20	pH 7.5, 25 °C	PMID 15456792	Open record: LpdA, 5-hydroxy-1,4-naphthaquinone
LpdA	Mycobacterium tuberculosis	oxidized thionicotinamide adenine dinucleotidecosubstrate NADH	—	0.0054	670	pH 7.5, 25 °C	PMID 15456792	Open record: LpdA, oxidized thionicotinamide adenine dinucleotide
LpdA	Mycobacterium tuberculosis	oxidized thionicotinamide adenine dinucleotidecosubstrate NADPH	—	0.018	0.49	pH 7.5, 25 °C	PMID 15456792	Open record: LpdA, oxidized thionicotinamide adenine dinucleotide
LpdA	Mycobacterium tuberculosis	reduced beta-nicotinamide adenine dinucleotide1% (v/v) acetonitrile (quinone stock solvent)	2.8	0.036	77	pH 7.5, 25 °C	PMID 15456792	Open record: LpdA, reduced beta-nicotinamide adenine dinucleotide
LpdA	Mycobacterium tuberculosis	reduced beta-nicotinamide adenine dinucleotide1% (v/v) acetonitrile (quinone stock solvent)	2.5	0.028	91	pH 7.5, 25 °C	PMID 15456792	Open record: LpdA, reduced beta-nicotinamide adenine dinucleotide
LpdA	Mycobacterium tuberculosis	reduced beta-nicotinamide adenine dinucleotidethio-NAD+ reduction followed at 398 nm	3.6	—	—	pH 7.5, 25 °C	PMID 15456792	Open record: LpdA, reduced beta-nicotinamide adenine dinucleotide
LpdA	Mycobacterium tuberculosis	reduced beta-nicotinamide adenine dinucleotide phosphate1% (v/v) acetonitrile (quinone stock solvent)	0.0077	5.3 × 10⁻⁴	14	pH 7.5, 25 °C	PMID 15456792	Open record: LpdA, reduced beta-nicotinamide adenine dinucleotide phosphate
LpdA	Mycobacterium tuberculosis	reduced beta-nicotinamide adenine dinucleotide phosphate1% (v/v) acetonitrile (quinone stock solvent)	0.0079	4.4 × 10⁻⁴	18	pH 7.5, 25 °C	PMID 15456792	Open record: LpdA, reduced beta-nicotinamide adenine dinucleotide phosphate
LpdA	Mycobacterium tuberculosis	reduced beta-nicotinamide adenine dinucleotide phosphatethio-NAD+ reduction followed at 398 nm	0.0087	—	—	pH 7.5, 25 °C	PMID 15456792	Open record: LpdA, reduced beta-nicotinamide adenine dinucleotide phosphate
NAD(P)H:acceptor oxidoreductase FerB	Paracoccus denitrificans	NADH	258	0.022	11,727	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant E77A	Paracoccus denitrificans	NADH	17.9	0.18	99	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant E77A, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant E77K	Paracoccus denitrificans	NADH	0.75	0.03	25	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant E77K, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant E77L	Paracoccus denitrificans	NADH	0.072	0.25	0.29	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant E77L, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant E77M	Paracoccus denitrificans	NADH	2.5	0.42	6	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant E77M, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant G115F	Paracoccus denitrificans	NADH	2.2	0.41	5.4	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant G115F, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant G115I	Paracoccus denitrificans	NADH	1.7	0.63	2.7	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant G115I, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant G118F	Paracoccus denitrificans	NADH	77	0.085	906	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant G118F, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant G118I	Paracoccus denitrificans	NADH	12	0.038	316	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant G118I, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant R80E	Paracoccus denitrificans	NADH	0.275	0.03	9.2	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant R80E, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant R80K	Paracoccus denitrificans	NADH	9.5	0.35	27	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant R80K, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant R80L	Paracoccus denitrificans	NADH	0.142	0.58	0.24	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant R80L, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant R80M	Paracoccus denitrificans	NADH	0.302	0.78	0.39	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant R80M, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant R95A	Paracoccus denitrificans	flavin adenine dinucleotide	38	0.095	400 calc.	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant R95A, flavin adenine dinucleotide
NAD(P)H:acceptor oxidoreductase FerBvariant R95A	Paracoccus denitrificans	flavin mononucleotide	50	0.111	450 calc.	pH 7.4, 30 °C	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant R95A, flavin mononucleotide
NAD(P)H:acceptor oxidoreductase FerBvariant R95A	Paracoccus denitrificans	NADH	146	0.02	7292	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant R95A, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant R95A	Paracoccus denitrificans	NADH	—	0.033	—	pH 7.4, 30 °C	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant R95A, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant R95A	Paracoccus denitrificans	riboflavin	75	0.059	1.3 × 10³ calc.	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant R95A, riboflavin
NAD(P)H:acceptor oxidoreductase FerBvariant R95E	Paracoccus denitrificans	NADH	21.1	0.07	302	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant R95E, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant S113A	Paracoccus denitrificans	NADH	76.7	0.06	1278	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant S113A, NADH
NAD(P)H:acceptor oxidoreductase FerBvariant Y78A	Paracoccus denitrificans	NADH	196	0.04	4.9 × 10³	pH 7.4	PMID 24817153	Open record: NAD(P)H:acceptor oxidoreductase FerB variant Y78A, NADH
NADPH quinone oxidoreductase (KmQOR)	Kluyveromyces marxianus	1,4-Benzoquinone	1.58 × 10⁴	1.8	8.8 × 10³	pH 6.5, 25 °C	PMID 14536026	Open record: NADPH quinone oxidoreductase (KmQOR), 1,4-Benzoquinone
NADPH quinone oxidoreductase (KmQOR)	Kluyveromyces marxianus	2,3-Dichloro-5,6-dicyano-1,4-benzoquinone	8.7	298.2	0.029	pH 6.5, 25 °C	PMID 14536026	Open record: NADPH quinone oxidoreductase (KmQOR), 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone
NADPH quinone oxidoreductase (KmQOR)	Kluyveromyces marxianus	Hydroquinone	27	647.5	0.0412	pH 6.5, 25 °C	PMID 14536026	Open record: NADPH quinone oxidoreductase (KmQOR), Hydroquinone
NADPH quinone oxidoreductase (KmQOR)	Kluyveromyces marxianus	Phenyl-1,4-benzoquinone	6	728.6	0.0082	pH 6.5, 25 °C	PMID 14536026	Open record: NADPH quinone oxidoreductase (KmQOR), Phenyl-1,4-benzoquinone
nitroreductase (NTR)	Escherichia coli	2-Nitrofuranfixed NADH at 60 μM; cosubstrate NADH	4.3	0.45	9.6 calc.	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), 2-Nitrofuran
nitroreductase (NTR)	Escherichia coli	2-Nitrofuranfixed NADPH at 60 μM; cosubstrate NADPH	4.5	0.47	9.6 calc.	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), 2-Nitrofuran
nitroreductase (NTR)	Escherichia coli	2-Nitrosotoluene	—	—	610	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), 2-Nitrosotoluene
nitroreductase (NTR)	Escherichia coli	2-Nitrotoluene	0.21	1	0.0201	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), 2-Nitrotoluene
nitroreductase (NTR)	Escherichia coli	NADHfixed nitrofurazone at 750 μM; cosubstrate nitrofurazone	11	0.006	1.8 × 10³ calc.	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), NADH
nitroreductase (NTR)	Escherichia coli	NADHfixed nitrofurantoin at 750 μM; cosubstrate nitrofurantoin	11.5	0.008	1.4 × 10³ calc.	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), NADH
nitroreductase (NTR)	Escherichia coli	NADHfixed 2-nitrofuran at 1 mM; initial rate monitored at 340 nm	4.3	0.003	1.4 × 10³ calc.	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), NADH
nitroreductase (NTR)	Escherichia coli	NADHreaction followed at 440 nm; cosubstrate nitrofurazone	—	0.35	—	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), NADH
nitroreductase (NTR)	Escherichia coli	NADPHfixed nitrofurazone at 750 μM; cosubstrate nitrofurazone	11.3	0.007	1.6 × 10³ calc.	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), NADPH
nitroreductase (NTR)	Escherichia coli	NADPHfixed nitrofurantoin at 750 μM; cosubstrate nitrofurantoin	11.7	0.008	1.5 × 10³ calc.	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), NADPH
nitroreductase (NTR)	Escherichia coli	NADPHfixed 2-nitrofuran at 1 mM; initial rate monitored at 340 nm	4.3	0.003	1.4 × 10³ calc.	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), NADPH
nitroreductase (NTR)	Escherichia coli	Nitrobenzene	—	—	0.65	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), Nitrobenzene
nitroreductase (NTR)	Escherichia coli	Nitrofurantoinfixed NADH at 60 μM; cosubstrate NADH	11.2	0.19	59 calc.	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), Nitrofurantoin
nitroreductase (NTR)	Escherichia coli	Nitrofurantoinfixed NADPH at 60 μM; cosubstrate NADPH	10.7	0.16	67 calc.	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), Nitrofurantoin
nitroreductase (NTR)	Escherichia coli	Nitrofurazonefixed NADH at 60 μM; cosubstrate NADH	10.7	0.16	67 calc.	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), Nitrofurazone
nitroreductase (NTR)	Escherichia coli	Nitrofurazonefixed NADPH at 60 μM; cosubstrate NADPH	10.5	0.17	62 calc.	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), Nitrofurazone
nitroreductase (NTR)	Escherichia coli	nitrofurazone	225	1.85	122 calc.	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), nitrofurazone
nitroreductase (NTR)	Escherichia coli	Nitrosobenzene	167	0.0109	1.52 × 10⁴	pH 7, 25 °C	PMID 15684426	Open record: nitroreductase (NTR), Nitrosobenzene
NQO1 (NAD(P)H:quinone oxidoreductase 1)	Homo sapiens	2,6-dichlorophenolindophenol	—	0.0061	—	pH 7.4	PMID 41879255	Open record: NQO1 (NAD(P)H:quinone oxidoreductase 1), 2,6-dichlorophenolindophenol
NQO1 (NAD(P)H:quinone oxidoreductase 1)	Homo sapiens	reduced beta-nicotinamide adenine dinucleotide	276	0.35	788	pH 7.4	PMID 41879255	Open record: NQO1 (NAD(P)H:quinone oxidoreductase 1), reduced beta-nicotinamide adenine dinucleotide
NQO1 (NAD(P)H:quinone oxidoreductase 1)variant Y126A	Homo sapiens	reduced beta-nicotinamide adenine dinucleotide	38	3.3	11.5	pH 7.4	PMID 41879255	Open record: NQO1 (NAD(P)H:quinone oxidoreductase 1) variant Y126A, reduced beta-nicotinamide adenine dinucleotide
NQO1 (NAD(P)H:quinone oxidoreductase 1)variant Y126F	Homo sapiens	reduced beta-nicotinamide adenine dinucleotide	72	1.1	65	pH 7.4	PMID 41879255	Open record: NQO1 (NAD(P)H:quinone oxidoreductase 1) variant Y126F, reduced beta-nicotinamide adenine dinucleotide
NQO1 (NAD(P)H:quinone oxidoreductase 1)variant Y128A	Homo sapiens	reduced beta-nicotinamide adenine dinucleotide	98	1.4	70	pH 7.4	PMID 41879255	Open record: NQO1 (NAD(P)H:quinone oxidoreductase 1) variant Y128A, reduced beta-nicotinamide adenine dinucleotide
NQO1 (NAD(P)H:quinone oxidoreductase 1)variant Y128F	Homo sapiens	reduced beta-nicotinamide adenine dinucleotide	142	2.9	49	pH 7.4	PMID 41879255	Open record: NQO1 (NAD(P)H:quinone oxidoreductase 1) variant Y128F, reduced beta-nicotinamide adenine dinucleotide
QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product)	Escherichia coli	methyl-1,4-benzoquinone	34.2	0.0656	522	pH 7.5	PMID 18455185	Open record: QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product), methyl-1,4-benzoquinone
QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product)	Escherichia coli	nicotinamide adenine dinucleotide phosphate, reduced form	—	0.018	—	pH 7.5	PMID 18455185	Open record: QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product), nicotinamide adenine dinucleotide phosphate, reduced form
QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product)variant N143A	Escherichia coli	methyl-1,4-benzoquinone	18.7	0.395	48	pH 7.5	PMID 18455185	Open record: QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product) variant N143A, methyl-1,4-benzoquinone
QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product)variant N143A	Escherichia coli	nicotinamide adenine dinucleotide phosphate, reduced form	—	0.0167	—	pH 7.5	PMID 18455185	Open record: QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product) variant N143A, nicotinamide adenine dinucleotide phosphate, reduced form
QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product)variant N143L	Escherichia coli	methyl-1,4-benzoquinone	25.2	0.403	63	pH 7.5	PMID 18455185	Open record: QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product) variant N143L, methyl-1,4-benzoquinone
QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product)variant N143L	Escherichia coli	nicotinamide adenine dinucleotide phosphate, reduced form	—	0.0139	—	pH 7.5	PMID 18455185	Open record: QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product) variant N143L, nicotinamide adenine dinucleotide phosphate, reduced form
QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product)variant W139A	Escherichia coli	methyl-1,4-benzoquinone	32.3	0.225	144	pH 7.5	PMID 18455185	Open record: QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product) variant W139A, methyl-1,4-benzoquinone
QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product)variant W139F	Escherichia coli	methyl-1,4-benzoquinone	37.1	0.0915	407	pH 7.5	PMID 18455185	Open record: QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product) variant W139F, methyl-1,4-benzoquinone
QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product)variant W139I	Escherichia coli	methyl-1,4-benzoquinone	53.5	0.195	278	pH 7.5	PMID 18455185	Open record: QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product) variant W139I, methyl-1,4-benzoquinone
QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product)variant Y140F	Escherichia coli	methyl-1,4-benzoquinone	45.2	0.0625	727	pH 7.5	PMID 18455185	Open record: QOR2 (NAD(P)H-dependent quinone oxidoreductase, ytfG gene product) variant Y140F, methyl-1,4-benzoquinone
WrbA (NAD(P)H:quinone oxidoreductase)	Archaeoglobus fulgidus	1,4-benzoquinone	3.2 × 10³	0.037	8.6 × 10⁴	pH 7.2, 37 °C	PMID 16672604	Open record: WrbA (NAD(P)H:quinone oxidoreductase), 1,4-benzoquinone
WrbA (NAD(P)H:quinone oxidoreductase)	Archaeoglobus fulgidus	NADH	120	0.019	6.3 × 10³	pH 7.2, 37 °C	PMID 16672604	Open record: WrbA (NAD(P)H:quinone oxidoreductase), NADH
WrbA (NAD(P)H:quinone oxidoreductase)	Archaeoglobus fulgidus	NADPH	170	0.031	5.5 × 10³	pH 7.2, 37 °C	PMID 16672604	Open record: WrbA (NAD(P)H:quinone oxidoreductase), NADPH
WrbA (NAD(P)H:quinone oxidoreductase)	Escherichia coli	1,4-benzoquinone	370	0.0058	6.4 × 10⁴	pH 7.2, 37 °C	PMID 16672604	Open record: WrbA (NAD(P)H:quinone oxidoreductase), 1,4-benzoquinone
WrbA (NAD(P)H:quinone oxidoreductase)	Escherichia coli	NADH	8.9	0.014	640	pH 7.2, 37 °C	PMID 16672604	Open record: WrbA (NAD(P)H:quinone oxidoreductase), NADH
WrbA (NAD(P)H:quinone oxidoreductase)	Escherichia coli	NADPH	6	0.17	35	pH 7.2, 37 °C	PMID 16672604	Open record: WrbA (NAD(P)H:quinone oxidoreductase), NADPH