EC 2.1.1.1: nicotinamide N-methyltransferase
TransferasesOpen in Browse
CatLog read 28 records for EC 2.1.1.1 from 3 papers, for 1 organism. Names in these papers: nicotinamide N-methyltransferase (NNMT), nicotinamide N-methyltransferase (hNNMT).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 5 records for EC 2.1.1.1 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.1.1.1 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase | Homo sapiens | 12 |
| Structural basis of substrate recognition in human nicotinamide N-methyltransferase | Homo sapiens | 8 |
| Kinetic Mechanism of Nicotinamide N-Methyltransferase | Homo sapiens | 8 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| nicotinamide N-methyltransferase (hNNMT)variant D197A/K100A/E101A/E103A | Homo sapiens | nicotinamide | 0.036 | 11.8 | 0.003 | pH 8.6, 37 °C | PMID 21823666 | Open record: nicotinamide N-methyltransferase (hNNMT) variant D197A/K100A/E101A/E103A, nicotinamide |
| nicotinamide N-methyltransferase (hNNMT)variant D197A/K100A/E101A/E103A | Homo sapiens | S-adenosyl-L-methionine | — | 2.73 | 0.013 | pH 8.6, 37 °C | PMID 21823666 | Open record: nicotinamide N-methyltransferase (hNNMT) variant D197A/K100A/E101A/E103A, S-adenosyl-L-methionine |
| nicotinamide N-methyltransferase (hNNMT)variant K100A/E101A/E103A | Homo sapiens | nicotinamide | 0.083 | 0.105 | 0.8 | pH 8.6, 37 °C | PMID 21823666 | Open record: nicotinamide N-methyltransferase (hNNMT) variant K100A/E101A/E103A, nicotinamide |
| nicotinamide N-methyltransferase (hNNMT)variant K100A/E101A/E103A | Homo sapiens | S-adenosyl-L-methionine | — | 0.005 | 17 | pH 8.6, 37 °C | PMID 21823666 | Open record: nicotinamide N-methyltransferase (hNNMT) variant K100A/E101A/E103A, S-adenosyl-L-methionine |
| nicotinamide N-methyltransferase (hNNMT)variant Y20A/K100A/E101A/E103A | Homo sapiens | nicotinamide | 0.031 | 6.3 | 0.005 | pH 8.6, 37 °C | PMID 21823666 | Open record: nicotinamide N-methyltransferase (hNNMT) variant Y20A/K100A/E101A/E103A, nicotinamide |
| nicotinamide N-methyltransferase (hNNMT)variant Y20A/K100A/E101A/E103A | Homo sapiens | S-adenosyl-L-methionine | — | 3.5 | 0.009 | pH 8.6, 37 °C | PMID 21823666 | Open record: nicotinamide N-methyltransferase (hNNMT) variant Y20A/K100A/E101A/E103A, S-adenosyl-L-methionine |
| nicotinamide N-methyltransferase (hNNMT)variant Y20F/K100A/E101A/E103A | Homo sapiens | nicotinamide | 0.041 | 0.24 | 0.17 | pH 8.6, 37 °C | PMID 21823666 | Open record: nicotinamide N-methyltransferase (hNNMT) variant Y20F/K100A/E101A/E103A, nicotinamide |
| nicotinamide N-methyltransferase (hNNMT)variant Y20F/K100A/E101A/E103A | Homo sapiens | S-adenosyl-L-methionine | — | 0.028 | 1.5 | pH 8.6, 37 °C | PMID 21823666 | Open record: nicotinamide N-methyltransferase (hNNMT) variant Y20F/K100A/E101A/E103A, S-adenosyl-L-methionine |
| nicotinamide N-methyltransferase (NNMT) | Homo sapiens | 1,2,3,4-tetrahydroisoquinoline | 0.04527 | 0.613 | 0.0739 | pH 8.6, 37 °C | PMID 27570878 | Open record: nicotinamide N-methyltransferase (NNMT), 1,2,3,4-tetrahydroisoquinoline |
| nicotinamide N-methyltransferase (NNMT) | Homo sapiens | 2-Methoxypyridine | 0.00265 | 0.548 | 0.0048 | pH 8.6, 37 °C | PMID 27570878 | Open record: nicotinamide N-methyltransferase (NNMT), 2-Methoxypyridine |
| nicotinamide N-methyltransferase (NNMT) | Homo sapiens | 2-Methylpyridine | 0.01039 | 2.029 | 0.0051 | pH 8.6, 37 °C | PMID 27570878 | Open record: nicotinamide N-methyltransferase (NNMT), 2-Methylpyridine |
| nicotinamide N-methyltransferase (NNMT) | Homo sapiens | 3-Acetylpyridine | 0.01444 | 0.727 | 0.0199 | pH 8.6, 37 °C | PMID 27570878 | Open record: nicotinamide N-methyltransferase (NNMT), 3-Acetylpyridine |
| nicotinamide N-methyltransferase (NNMT) | Homo sapiens | 4-Methylnicotinamide | 0.09135 | 0.335 | 0.2727 | pH 8.6, 37 °C | PMID 27570878 | Open record: nicotinamide N-methyltransferase (NNMT), 4-Methylnicotinamide |
| nicotinamide N-methyltransferase (NNMT) | Homo sapiens | Isoquinoline | 0.01718 | 0.087 | 0.1975 | pH 8.6, 37 °C | PMID 27570878 | Open record: nicotinamide N-methyltransferase (NNMT), Isoquinoline |
| nicotinamide N-methyltransferase (NNMT) | Homo sapiens | Nicotinimidamide | 0.0135 | 1.326 | 0.0102 | pH 8.6, 37 °C | PMID 27570878 | Open record: nicotinamide N-methyltransferase (NNMT), Nicotinimidamide |
| nicotinamide N-methyltransferase (NNMT) | Homo sapiens | pyridine-3-carboxamide | 0.1016 | 0.199 | 0.5104 | pH 8.6, 37 °C | PMID 27570878 | Open record: nicotinamide N-methyltransferase (NNMT), pyridine-3-carboxamide |
| nicotinamide N-methyltransferase (NNMT) | Homo sapiens | Quinoline | 0.04639 | 0.609 | 0.0762 | pH 8.6, 37 °C | PMID 27570878 | Open record: nicotinamide N-methyltransferase (NNMT), Quinoline |
| nicotinamide N-methyltransferase (NNMT) | Homo sapiens | Quinoline-3-carboxamide | 0.00733 | 0.364 | 0.0201 | pH 8.6, 37 °C | PMID 27570878 | Open record: nicotinamide N-methyltransferase (NNMT), Quinoline-3-carboxamide |
| nicotinamide N-methyltransferase (NNMT) | Homo sapiens | S-adenosyl-L-methionine | — | 0.0085 | — | pH 8.6, 37 °C | PMID 27570878 | Open record: nicotinamide N-methyltransferase (NNMT), S-adenosyl-L-methionine |
| nicotinamide N-methyltransferase (NNMT) | Homo sapiens | Thionicotinamide | 0.03336 | 0.111 | 0.3005 | pH 8.6, 37 °C | PMID 27570878 | Open record: nicotinamide N-methyltransferase (NNMT), Thionicotinamide |
| nicotinamide N-methyltransferase (NNMT)variant K100A/E101A/E103A | Homo sapiens | nicotinamide | 0.014 | 0.003 | 4.7 | pH 8.6 | PMID 30148963 | Open record: nicotinamide N-methyltransferase (NNMT) variant K100A/E101A/E103A, nicotinamide |
| nicotinamide N-methyltransferase (NNMT)variant K100A/E101A/E103A | Homo sapiens | quinoline | 0.0125 | 0.017 | 0.735 | pH 8.6, 25 °C | PMID 30148963 | Open record: nicotinamide N-methyltransferase (NNMT) variant K100A/E101A/E103A, quinoline |
| nicotinamide N-methyltransferase (NNMT)variant K100A/E101A/E103A | Homo sapiens | quinoline | 0.011 | 0.01 | 1.1 | pH 8.6 | PMID 30148963 | Open record: nicotinamide N-methyltransferase (NNMT) variant K100A/E101A/E103A, quinoline |
| nicotinamide N-methyltransferase (NNMT)variant K100A/E101A/E103A | Homo sapiens | quinolineglobal fit to eq 1 (Table 2 row 1) | 0.007 | 0.0092 | 0.76 calc. | pH 8.6, 25 °C | PMID 30148963 | Open record: nicotinamide N-methyltransferase (NNMT) variant K100A/E101A/E103A, quinoline |
| nicotinamide N-methyltransferase (NNMT)variant K100A/E101A/E103A | Homo sapiens | quinolineglobal fit to eq 1 (Table 2 row 2) | — | 0.015 | — | pH 8.6, 25 °C | PMID 30148963 | Open record: nicotinamide N-methyltransferase (NNMT) variant K100A/E101A/E103A, quinoline |
| nicotinamide N-methyltransferase (NNMT)variant K100A/E101A/E103A | Homo sapiens | S-adenosylmethionine | 0.008 | 0.01 | 0.75 | pH 8.6, 25 °C | PMID 30148963 | Open record: nicotinamide N-methyltransferase (NNMT) variant K100A/E101A/E103A, S-adenosylmethionine |
| nicotinamide N-methyltransferase (NNMT)variant K100A/E101A/E103A | Homo sapiens | S-adenosylmethionineglobal fit to eq 1 (Table 2 row 1) | — | 0.012 | — | pH 8.6, 25 °C | PMID 30148963 | Open record: nicotinamide N-methyltransferase (NNMT) variant K100A/E101A/E103A, S-adenosylmethionine |
| nicotinamide N-methyltransferase (NNMT)variant K100A/E101A/E103A | Homo sapiens | S-adenosylmethionineglobal fit to eq 1 (Table 2 row 2) | 0.006 | 0.0068 | 0.88 calc. | pH 8.6, 25 °C | PMID 30148963 | Open record: nicotinamide N-methyltransferase (NNMT) variant K100A/E101A/E103A, S-adenosylmethionine |