EC 2.1.1.361: [histone H4]-lysine20 N-methyltransferase
TransferasesOpen in Browse
CatLog read 38 records for EC 2.1.1.361 from 2 papers, for 1 organism. Names in these papers: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), PRDM9 (PR domain-containing protein 9, histone methyltransferase).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 5 records for EC 2.1.1.361 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.1.1.361 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase | Homo sapiens | 24 |
| PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase | Homo sapiens | 14 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKKHRKVLRD-NH2 | 0.0023 | 1.89 | 0.0012 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKKHRKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKQHRKVLRD-NH2 | 0.002 | 1.98 | 0.001 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKQHRKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRERKVLRD-NH2 | — | — | 0.0015 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRERKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRFRKVLRD-NH2 | 0.0058 | 0.42 | 0.014 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRFRKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRHAKVLRD-NH2 | 0.0057 | 0.31 | 0.018 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRHAKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRHEKVLRD-NH2 | 0.004 | 1.99 | 0.002 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRHEKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRHKKVLRD-NH2 | 0.0065 | 0.36 | 0.018 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRHKKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRHQKVLRD-NH2 | 0.0047 | 0.53 | 0.0088 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRHQKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRHRKALRD-NH2 | 0.0018 | 0.39 | 0.0048 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRHRKALRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRHRKFLRD-NH2 | 0.0058 | 0.16 | 0.035 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRHRKFLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRHRKVARD-NH2 | — | — | 3.3 × 10⁻⁴ | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRHRKVARD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRHRKVFRD-NH2 | 0.006 | 0.11 | 0.053 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRHRKVFRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRHRKVLAD-NH2 | 0.006 | 0.21 | 0.028 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRHRKVLAD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRHRKVLED-NH2 | 0.0043 | 0.29 | 0.0152 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRHRKVLED-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRHRKVLLD-NH2 | 0.0067 | 0.022 | 0.37 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRHRKVLLD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) | Homo sapiens | Ac-AKRHRKVLRD-NH2 | 0.0072 | 0.4 | 0.018 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase), Ac-AKRHRKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase)variant C270A | Homo sapiens | Ac-AKRHRKVLRD-NH2 | — | — | 0.0015 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) variant C270A, Ac-AKRHRKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase)variant E259A | Homo sapiens | Ac-AKRHRKVLRD-NH2 | — | — | 0.001 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) variant E259A, Ac-AKRHRKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase)variant E259Q | Homo sapiens | Ac-AKRHRKVLRD-NH2 | 0.002 | 0.87 | 0.0023 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) variant E259Q, Ac-AKRHRKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase)variant H347A | Homo sapiens | Ac-AKRHRKVLRD-NH2 | 0.0033 | 1.02 | 0.0033 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) variant H347A, Ac-AKRHRKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase)variant H347E | Homo sapiens | Ac-AKRHRKVLRD-NH2 | 0.0013 | 0.47 | 0.0028 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) variant H347E, Ac-AKRHRKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase)variant H347F | Homo sapiens | Ac-AKRHRKVLRD-NH2 | 0.0035 | 0.0074 | 0.47 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) variant H347F, Ac-AKRHRKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase)variant Y334A | Homo sapiens | Ac-AKRHRKVLRD-NH2 | — | — | 8.3 × 10⁻⁵ | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) variant Y334A, Ac-AKRHRKVLRD-NH2 |
| hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase)variant Y334F | Homo sapiens | Ac-AKRHRKVLRD-NH2 | 0.0075 | 0.52 | 0.015 | pH 7.5 | PMID 15933070 | Open record: hSET8 (SET8/PR-SET7, histone H4 Lys-20 methyltransferase) variant Y334F, Ac-AKRHRKVLRD-NH2 |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | biotinylated histone H3 residues 1–25 peptide ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 monomethylated) | 7.36 | 0.005 | 1.5 × 10³ calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, biotinylated histone H3 residues 1–25 peptide ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 monomethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | biotinylated histone H3 residues 1–25 peptide ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 dimethylated) | 5.42 | 0.006 | 900 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, biotinylated histone H3 residues 1–25 peptide ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 dimethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | biotinylated histone H3 residues 1–25 peptide ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin (unmethylated Lys-4) | 8.42 | 0.004 | 2.1 × 10³ calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, biotinylated histone H3 residues 1–25 peptide ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin (unmethylated Lys-4) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme1)KPHRYRPG-GK-biotin (Lys-36 monomethylated) | 2 | 7 × 10⁻⁴ | 2.9 × 10³ calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme1)KPHRYRPG-GK-biotin (Lys-36 monomethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme2)KPHRYRPG-GK-biotin (Lys-36 dimethylated) | 9.7 | 0.015 | 650 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme2)KPHRYRPG-GK-biotin (Lys-36 dimethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGVKKPHRYRPG-GK-biotin (unmethylated Lys-36) | 4.92 | 0.003 | 1.6 × 10³ calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGVKKPHRYRPG-GK-biotin (unmethylated Lys-36) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)PRDM9 (7 tail) chimera | Homo sapiens | S-adenosylmethionine | 3 | 0.024 | 120 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) PRDM9 (7 tail) chimera, S-adenosylmethionine |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | biotinylated histone H3 residues 1–25 peptide ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 monomethylated) | 1.9 × 10⁻⁴ | 4 × 10⁻⁴ | 0.49 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, biotinylated histone H3 residues 1–25 peptide ART(Kme1)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 monomethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | biotinylated histone H3 residues 1–25 peptide ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 dimethylated) | 2.2 × 10⁻⁴ | 1 × 10⁻⁴ | 2.2 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, biotinylated histone H3 residues 1–25 peptide ART(Kme2)QTARKSTGGKAPRKQLATKAA-GK-biotin (Lys-4 dimethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | biotinylated histone H3 residues 1–25 peptide ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin (unmethylated Lys-4) | 1.7 × 10⁻⁴ | 1 × 10⁻⁴ | 1.7 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, biotinylated histone H3 residues 1–25 peptide ARTKQTARKSTGGKAPRKQLATKAA-GK-biotin (unmethylated Lys-4) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme1)KPHRYRPG-GK-biotin (Lys-36 monomethylated) | 1.1 × 10⁻⁴ | 3 × 10⁻⁴ | 0.37 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme1)KPHRYRPG-GK-biotin (Lys-36 monomethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme2)KPHRYRPG-GK-biotin (Lys-36 dimethylated) | 5.6 × 10⁻⁴ | 0.003 | 0.19 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGV(Kme2)KPHRYRPG-GK-biotin (Lys-36 dimethylated) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGVKKPHRYRPG-GK-biotin (unmethylated Lys-36) | 1.4 × 10⁻⁴ | 5 × 10⁻⁴ | 0.28 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, biotinylated histone H3 residues 21–44 peptide ATKAARKSAPATGGVKKPHRYRPG-GK-biotin (unmethylated Lys-36) |
| PRDM9 (PR domain-containing protein 9, histone methyltransferase)variant Y357S | Homo sapiens | S-adenosylmethionine | 2.2 × 10⁻⁴ | 0.008 | 0.028 calc. | pH 9, 23 °C | PMID 27129774 | Open record: PRDM9 (PR domain-containing protein 9, histone methyltransferase) variant Y357S, S-adenosylmethionine |