CatLogenzyme kinetics catalog

EC 2.1.1.6: catechol O-methyltransferase

TransferasesOpen in Browse

CatLog read 38 records for EC 2.1.1.6 from 1 paper, for 1 organism. Names in these papers: soluble catechol-O-methyltransferase (S-COMT, Val108 form), membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 36 records for EC 2.1.1.6 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.1.1.6 in Browse.

Papers

PaperOrganismsRecords
Biochemical and molecular modeling studies of the O-methylation of various endogenous and exogenous catechol substrates catalyzed by recombinant human soluble and membrane-bound…Homo sapiens38

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiens2-hydroxyestradiol0.0850.003227 calc.pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiens2-hydroxyestradiol—0.0039—pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiens2-hydroxyestradiol—0.005—pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiens4-hydroxyestradiol0.0770.006412 calc.pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapienscatechin0.2570.0022120 calc.pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensdopaminetotal methylation (3-O- plus 4-O-methyl ethers)0.1930.01711 calc.pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensdopamine—0.0157—pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensdopamine—0.046—pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensepicatechin0.3150.004373 calc.pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensepinephrinetotal methylation (3-O- plus 4-O-methyl ethers)0.2480.02888.62 calc.pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensepinephrine—0.0279—pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensepinephrine—0.0592—pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensnorepinephrinetotal methylation (3-O- plus 4-O-methyl ethers)0.1780.03065.83 calc.pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensnorepinephrine—0.0296—pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensnorepinephrine—0.0682—pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensS-adenosyl-L-methioninefixed 10 µM 2-OH-E2; cosubstrate 2-OH-E2 (10 µM)—0.0183—pH 7.4, 37 °CPMID 17880176Open
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensS-adenosyl-L-methioninefixed 10 µM 4-OH-E2; cosubstrate 4-OH-E2 (10 µM)—0.0171—pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiens2-hydroxyestradiol0.0980.003627 calc.pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiens2-hydroxyestradiol—0.0046—pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiens2-hydroxyestradiol—0.0041—pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiens4-hydroxyestradiol0.0350.00457.8 calc.pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapienscatechin0.1820.008920 calc.pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensdopaminetotal methylation (3-O- plus 4-O-methyl ethers)0.0880.26320.34 calc.pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensdopamine—0.2675—pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensdopamine—0.2462—pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensepicatechin0.170.02576.6 calc.pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensepinephrinetotal methylation (3-O- plus 4-O-methyl ethers)0.0850.39470.22 calc.pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensepinephrine—0.4068—pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensepinephrine—0.3118—pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensfisetin250 µM AdoMet ([methyl-3H]AdoMet)0.1150.001577 calc.pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensfisetin100 µM AdoMet ([methyl-3H]AdoMet)—0.0013—pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensnorepinephrinetotal methylation (3-O- plus 4-O-methyl ethers)0.0420.22410.19 calc.pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensnorepinephrine—0.2469—pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensnorepinephrine—0.1246—pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensquercetin250 µM AdoMet ([methyl-3H]AdoMet)0.070.001547 calc.pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensquercetin100 µM AdoMet ([methyl-3H]AdoMet)—0.0016—pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensS-adenosyl-L-methioninefixed 10 µM 2-OH-E2; cosubstrate 2-OH-E2 (10 µM)—0.1136—pH 7.4, 37 °CPMID 17880176Open
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensS-adenosyl-L-methioninefixed 10 µM 4-OH-E2; cosubstrate 4-OH-E2 (10 µM)—0.1453—pH 7.4, 37 °CPMID 17880176Open