CatLogenzyme kinetics catalog

Values CatLog read from this paper

Biochemical and molecular modeling studies of the O-methylation of various endogenous and exogenous catechol substrates catalyzed by recombinant human soluble and membrane-bound…

PMID 17880176doi:10.1021/tx700174wOpen in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 38 records (54 values) from this paper: soluble catechol-O-methyltransferase (S-COMT, Val108 form), membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 16 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.

EC 2.1.1.6

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiens2-hydroxyestradiol0.0850.003227 calc.pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiens2-hydroxyestradiol—0.0039—pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiens2-hydroxyestradiol—0.005—pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiens4-hydroxyestradiol0.0770.006412 calc.pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapienscatechin0.2570.0022120 calc.pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensdopaminetotal methylation (3-O- plus 4-O-methyl ethers)0.1930.01711 calc.pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensdopamine—0.0157—pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensdopamine—0.046—pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensepicatechin0.3150.004373 calc.pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensepinephrinetotal methylation (3-O- plus 4-O-methyl ethers)0.2480.02888.62 calc.pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensepinephrine—0.0279—pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensepinephrine—0.0592—pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensnorepinephrinetotal methylation (3-O- plus 4-O-methyl ethers)0.1780.03065.83 calc.pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensnorepinephrine—0.0296—pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensnorepinephrine—0.0682—pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensS-adenosyl-L-methioninefixed 10 µM 2-OH-E2; cosubstrate 2-OH-E2 (10 µM)—0.0183—pH 7.4, 37 °COpen
membrane-bound catechol-O-methyltransferase (MB-COMT, Val158 form)Homo sapiensS-adenosyl-L-methioninefixed 10 µM 4-OH-E2; cosubstrate 4-OH-E2 (10 µM)—0.0171—pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiens2-hydroxyestradiol0.0980.003627 calc.pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiens2-hydroxyestradiol—0.0046—pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiens2-hydroxyestradiol—0.0041—pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiens4-hydroxyestradiol0.0350.00457.8 calc.pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapienscatechin0.1820.008920 calc.pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensdopaminetotal methylation (3-O- plus 4-O-methyl ethers)0.0880.26320.34 calc.pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensdopamine—0.2675—pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensdopamine—0.2462—pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensepicatechin0.170.02576.6 calc.pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensepinephrinetotal methylation (3-O- plus 4-O-methyl ethers)0.0850.39470.22 calc.pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensepinephrine—0.4068—pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensepinephrine—0.3118—pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensfisetin250 µM AdoMet ([methyl-3H]AdoMet)0.1150.001577 calc.pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensfisetin100 µM AdoMet ([methyl-3H]AdoMet)—0.0013—pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensnorepinephrinetotal methylation (3-O- plus 4-O-methyl ethers)0.0420.22410.19 calc.pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensnorepinephrine—0.2469—pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensnorepinephrine—0.1246—pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensquercetin250 µM AdoMet ([methyl-3H]AdoMet)0.070.001547 calc.pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensquercetin100 µM AdoMet ([methyl-3H]AdoMet)—0.0016—pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensS-adenosyl-L-methioninefixed 10 µM 2-OH-E2; cosubstrate 2-OH-E2 (10 µM)—0.1136—pH 7.4, 37 °COpen
soluble catechol-O-methyltransferase (S-COMT, Val108 form)Homo sapiensS-adenosyl-L-methioninefixed 10 µM 4-OH-E2; cosubstrate 4-OH-E2 (10 µM)—0.1453—pH 7.4, 37 °COpen