EC 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase
TransferasesOpen in Browse
CatLog read 36 records for EC 2.2.1.7 from 3 papers, for 2 organisms. Names in these papers: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS), 1-deoxy-D-xylulose 5-phosphate synthase (DXS), 1-deoxy-D-xylulose-5-phosphate synthase (DXPS).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 53 records for EC 2.2.1.7 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.2.1.7 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design | Escherichia coli | 16 |
| Thiamin Diphosphate Activation in 1-Deoxy-d-xylulose 5-Phosphate Synthase: Insights into the Mechanism and Underlying Intermolecular Interactions | Deinococcus radiodurans | 10 |
| Mechanistic Studies of 1-Deoxy-D-Xylulose-5-Phosphate Synthase from Deinococcus radiodurans | Deinococcus radiodurans | 10 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| 1-deoxy-D-xylulose 5-phosphate synthase (DXS) | Deinococcus radiodurans | glyceraldehyde 3-phosphate | 7.9 | 0.05 | 150 | pH 8, 37 °C | PMID 27537621 | Open record: 1-deoxy-D-xylulose 5-phosphate synthase (DXS), glyceraldehyde 3-phosphate |
| 1-deoxy-D-xylulose 5-phosphate synthase (DXS) | Deinococcus radiodurans | pyruvate | 7.4 | 0.28 | 26 | pH 8, 37 °C | PMID 27537621 | Open record: 1-deoxy-D-xylulose 5-phosphate synthase (DXS), pyruvate |
| 1-deoxy-D-xylulose 5-phosphate synthase (DXS)variant D430A | Deinococcus radiodurans | glyceraldehyde 3-phosphate | 7.7 | 0.12 | 66 | pH 8, 37 °C | PMID 27537621 | Open record: 1-deoxy-D-xylulose 5-phosphate synthase (DXS) variant D430A, glyceraldehyde 3-phosphate |
| 1-deoxy-D-xylulose 5-phosphate synthase (DXS)variant D430A | Deinococcus radiodurans | pyruvate | 7.2 | 0.52 | 14 | pH 8, 37 °C | PMID 27537621 | Open record: 1-deoxy-D-xylulose 5-phosphate synthase (DXS) variant D430A, pyruvate |
| 1-deoxy-D-xylulose 5-phosphate synthase (DXS)variant H304A | Deinococcus radiodurans | glyceraldehyde 3-phosphate | 0.9 | 0.08 | 11 | pH 8, 37 °C | PMID 27537621 | Open record: 1-deoxy-D-xylulose 5-phosphate synthase (DXS) variant H304A, glyceraldehyde 3-phosphate |
| 1-deoxy-D-xylulose 5-phosphate synthase (DXS)variant H304A | Deinococcus radiodurans | pyruvate | 0.9 | 1.7 | 0.58 | pH 8, 37 °C | PMID 27537621 | Open record: 1-deoxy-D-xylulose 5-phosphate synthase (DXS) variant H304A, pyruvate |
| 1-deoxy-D-xylulose 5-phosphate synthase (DXS)variant H434A | Deinococcus radiodurans | glyceraldehyde 3-phosphate | 9.6 | 0.23 | 42 | pH 8, 37 °C | PMID 27537621 | Open record: 1-deoxy-D-xylulose 5-phosphate synthase (DXS) variant H434A, glyceraldehyde 3-phosphate |
| 1-deoxy-D-xylulose 5-phosphate synthase (DXS)variant H434A | Deinococcus radiodurans | pyruvate | 9.9 | 1.7 | 5.9 | pH 8, 37 °C | PMID 27537621 | Open record: 1-deoxy-D-xylulose 5-phosphate synthase (DXS) variant H434A, pyruvate |
| 1-deoxy-D-xylulose 5-phosphate synthase (DXS)variant H82A | Deinococcus radiodurans | glyceraldehyde 3-phosphate | 0.37 | 0.03 | 13 | pH 8, 37 °C | PMID 27537621 | Open record: 1-deoxy-D-xylulose 5-phosphate synthase (DXS) variant H82A, glyceraldehyde 3-phosphate |
| 1-deoxy-D-xylulose 5-phosphate synthase (DXS)variant H82A | Deinococcus radiodurans | pyruvate | 0.38 | 0.23 | 1.7 | pH 8, 37 °C | PMID 27537621 | Open record: 1-deoxy-D-xylulose 5-phosphate synthase (DXS) variant H82A, pyruvate |
| 1-deoxy-D-xylulose-5-phosphate synthase (DXPS)variant D430A | Deinococcus radiodurans | pyruvate | — | 0.52 | — | pH 8, 37 °C | PMID 29552677 | Open record: 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) variant D430A, pyruvate |
| 1-deoxy-D-xylulose-5-phosphate synthase (DXPS)variant N181A | Deinococcus radiodurans | D-glyceraldehyde 3-phosphate | 0.43 | 0.03 | 14 | pH 8, 37 °C | PMID 29552677 | Open record: 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) variant N181A, D-glyceraldehyde 3-phosphate |
| 1-deoxy-D-xylulose-5-phosphate synthase (DXPS)variant N181A | Deinococcus radiodurans | pyruvate | 3.3 | 0.17 | 19 | pH 8, 37 °C | PMID 29552677 | Open record: 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) variant N181A, pyruvate |
| 1-deoxy-D-xylulose-5-phosphate synthase (DXPS)variant R423A | Deinococcus radiodurans | D-glyceraldehyde 3-phosphate | 1.7 | 12 | 0.14 | pH 8, 37 °C | PMID 29552677 | Open record: 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) variant R423A, D-glyceraldehyde 3-phosphate |
| 1-deoxy-D-xylulose-5-phosphate synthase (DXPS)variant R423K | Deinococcus radiodurans | D-glyceraldehyde 3-phosphate | 6.4 | 0.6 | 11 | pH 8, 37 °C | PMID 29552677 | Open record: 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) variant R423K, D-glyceraldehyde 3-phosphate |
| 1-deoxy-D-xylulose-5-phosphate synthase (DXPS)variant R423K | Deinococcus radiodurans | pyruvate | 3.9 | 0.06 | 65 | pH 8, 37 °C | PMID 29552677 | Open record: 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) variant R423K, pyruvate |
| 1-deoxy-D-xylulose-5-phosphate synthase (DXPS)variant Y395A | Deinococcus radiodurans | D-glyceraldehyde 3-phosphate | 3.9 | 0.67 | 5.8 | pH 8, 37 °C | PMID 29552677 | Open record: 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) variant Y395A, D-glyceraldehyde 3-phosphate |
| 1-deoxy-D-xylulose-5-phosphate synthase (DXPS)variant Y395A | Deinococcus radiodurans | pyruvate | 3.6 | 0.16 | 22 | pH 8, 37 °C | PMID 29552677 | Open record: 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) variant Y395A, pyruvate |
| 1-deoxy-D-xylulose-5-phosphate synthase (DXPS)variant Y395F | Deinococcus radiodurans | D-glyceraldehyde 3-phosphate | 5.9 | 0.59 | 10 | pH 8, 37 °C | PMID 29552677 | Open record: 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) variant Y395F, D-glyceraldehyde 3-phosphate |
| 1-deoxy-D-xylulose-5-phosphate synthase (DXPS)variant Y395F | Deinococcus radiodurans | pyruvate | 2.9 | 0.19 | 16 | pH 8, 37 °C | PMID 29552677 | Open record: 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) variant Y395F, pyruvate |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) | Escherichia coli | 1-methyl-2-nitrosobenzene | 0.6 | 0.099 | 6 | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS), 1-methyl-2-nitrosobenzene |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) | Escherichia coli | 1-nitrosonaphthalen-2-ol | 0.018 | 0.041 | 0.45 | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS), 1-nitrosonaphthalen-2-ol |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) | Escherichia coli | 2-hydroxy-4,6-dinitrobenzaldehyde | 0.0058 | 0.512 | 0.011 calc. | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS), 2-hydroxy-4,6-dinitrobenzaldehyde | |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) | Escherichia coli | 3,5-dimethyl-4-nitroso-1-(propan-2-yl)-1H-pyrazole | 0.023 | 0.387 | 0.06 | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS), 3,5-dimethyl-4-nitroso-1-(propan-2-yl)-1H-pyrazole |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) | Escherichia coli | 6-bromo-1-nitrosonaphthalen-2-ol | 0.033 | 0.024 | 1.3 | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS), 6-bromo-1-nitrosonaphthalen-2-ol |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) | Escherichia coli | 6-hydroxy-5-nitrosonaphthalene-2-sulfonamide | 0.0197 | 0.018 | 1.1 | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS), 6-hydroxy-5-nitrosonaphthalene-2-sulfonamide |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) | Escherichia coli | 7-methoxy-1-nitrosonaphthalen-2-ol | 0.022 | 0.063 | 0.35 | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS), 7-methoxy-1-nitrosonaphthalen-2-ol |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) | Escherichia coli | D-glyceraldehyde 3-phosphate | 1.7 | 0.028 | 60.7 | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS), D-glyceraldehyde 3-phosphate |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) | Escherichia coli | N,N-dimethyl-4-nitrosoaniline | 0.015 | 0.054 | 0.28 | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS), N,N-dimethyl-4-nitrosoaniline |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) | Escherichia coli | nitrosobenzene | 2.92 | 0.133 | 22 | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS), nitrosobenzene |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS)variant R420A | Escherichia coli | 1-nitrosonaphthalen-2-ol | — | 0.032 | — | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) variant R420A, 1-nitrosonaphthalen-2-ol |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS)variant R420A | Escherichia coli | 6-bromo-1-nitrosonaphthalen-2-ol | — | 0.016 | — | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) variant R420A, 6-bromo-1-nitrosonaphthalen-2-ol |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS)variant R420A | Escherichia coli | 6-hydroxy-5-nitrosonaphthalene-2-sulfonamide | — | 0.014 | — | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) variant R420A, 6-hydroxy-5-nitrosonaphthalene-2-sulfonamide |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS)variant R478A | Escherichia coli | 1-nitrosonaphthalen-2-ol | — | 0.023 | — | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) variant R478A, 1-nitrosonaphthalen-2-ol |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS)variant R478A | Escherichia coli | 6-bromo-1-nitrosonaphthalen-2-ol | — | 0.02 | — | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) variant R478A, 6-bromo-1-nitrosonaphthalen-2-ol |
| DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS)variant R478A | Escherichia coli | 6-hydroxy-5-nitrosonaphthalene-2-sulfonamide | — | 0.013 | — | pH 8, 37 °C | PMID 23824585 | Open record: DXP synthase (1-deoxy-D-xylulose 5-phosphate synthase, DXPS) variant R478A, 6-hydroxy-5-nitrosonaphthalene-2-sulfonamide |