EC 2.3.1.39: [acyl-carrier-protein] S-malonyltransferase
TransferasesOpen in Browse
CatLog read 41 records for EC 2.3.1.39 from 3 papers, for 3 organisms. Names in these papers: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS), FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), FabD (malonyl-CoA/holo-ACP transacylase).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 46 records for EC 2.3.1.39 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.3.1.39 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering | Mus musculus | 17 |
| FenF: servicing the Mycosubtilin synthetase assembly line in trans | Bacillus subtilis | 14 |
| The R117A variant of the Escherichia coli transacylase FabD synthesizes novel acyl-(acyl carrier proteins) | Escherichia coli | 10 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| FabD (malonyl-CoA/holo-ACP transacylase) | Escherichia coli | holo-acyl carrier protein | 400 | 0.02 | 2.0 × 10⁴ calc. | PMID 29075826 | Open record: FabD (malonyl-CoA/holo-ACP transacylase), holo-acyl carrier protein | |
| FabD (malonyl-CoA/holo-ACP transacylase) | Escherichia coli | methylmalonyl-coenzyme A | 1 × 10³ | 0.58 | 1.7 × 10³ calc. | PMID 29075826 | Open record: FabD (malonyl-CoA/holo-ACP transacylase), methylmalonyl-coenzyme A | |
| FabD (malonyl-CoA/holo-ACP transacylase)variant R117A | Escherichia coli | acetoacetyl-coenzyme A | 0.041 | 0.11 | 0.37 calc. | PMID 29075826 | Open record: FabD (malonyl-CoA/holo-ACP transacylase) variant R117A, acetoacetyl-coenzyme A | |
| FabD (malonyl-CoA/holo-ACP transacylase)variant R117A | Escherichia coli | acetyl-coenzyme A | 0.029 | 0.2 | 0.14 calc. | PMID 29075826 | Open record: FabD (malonyl-CoA/holo-ACP transacylase) variant R117A, acetyl-coenzyme A | |
| FabD (malonyl-CoA/holo-ACP transacylase)variant R117A | Escherichia coli | holo-acyl carrier proteinat 250 µM acyl-CoA; cosubstrate malonyl-CoA | 11 | 0.03 | 370 calc. | PMID 29075826 | Open record: FabD (malonyl-CoA/holo-ACP transacylase) variant R117A, holo-acyl carrier protein | |
| FabD (malonyl-CoA/holo-ACP transacylase)variant R117A | Escherichia coli | holo-acyl carrier proteinat 250 µM acyl-CoA; cosubstrate methylmalonyl-CoA | 2.6 | 0.011 | 240 calc. | PMID 29075826 | Open record: FabD (malonyl-CoA/holo-ACP transacylase) variant R117A, holo-acyl carrier protein | |
| FabD (malonyl-CoA/holo-ACP transacylase)variant R117A | Escherichia coli | holo-acyl carrier proteincosubstrate acetoacetyl-CoA | 0.038 | 0.03 | 1.3 calc. | PMID 29075826 | Open record: FabD (malonyl-CoA/holo-ACP transacylase) variant R117A, holo-acyl carrier protein | |
| FabD (malonyl-CoA/holo-ACP transacylase)variant R117A | Escherichia coli | holo-acyl carrier proteincosubstrate acetyl-CoA | 0.052 | 0.04 | 1.3 calc. | PMID 29075826 | Open record: FabD (malonyl-CoA/holo-ACP transacylase) variant R117A, holo-acyl carrier protein | |
| FabD (malonyl-CoA/holo-ACP transacylase)variant R117A | Escherichia coli | malonyl-coenzyme A | 8.5 | 0.08 | 110 calc. | PMID 29075826 | Open record: FabD (malonyl-CoA/holo-ACP transacylase) variant R117A, malonyl-coenzyme A | |
| FabD (malonyl-CoA/holo-ACP transacylase)variant R117A | Escherichia coli | methylmalonyl-coenzyme A | 5 | 0.33 | 15 calc. | PMID 29075826 | Open record: FabD (malonyl-CoA/holo-ACP transacylase) variant R117A, methylmalonyl-coenzyme A | |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | acetyl-coenzyme A | 0.13 | 1.25 | 0.1 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), acetyl-coenzyme A |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | holo-ACP1: excised first acyl carrier protein domain of MycA, phosphopantetheinylated, N-terminally His6-tagged | — | 2.7 | 5.5 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), holo-ACP1: excised first acyl carrier protein domain of MycA, phosphopantetheinylated, N-terminally His6-tagged |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | holo-ACP2: excised second acyl carrier protein domain of MycA, phosphopantetheinylated, N-terminally His6-taggedFenF 4 nM; cosubstrate malonyl CoA | — | 0.95 | 18 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), holo-ACP2: excised second acyl carrier protein domain of MycA, phosphopantetheinylated, N-terminally His6-tagged |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | holo-ACP2: excised second acyl carrier protein domain of MycA, phosphopantetheinylated, N-terminally His6-taggedcosubstrate Me malonyl CoA | — | 0.56 | 0.13 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), holo-ACP2: excised second acyl carrier protein domain of MycA, phosphopantetheinylated, N-terminally His6-tagged |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | holo-ACP2: excised second acyl carrier protein domain of MycA, phosphopantetheinylated, N-terminally His6-taggedcosubstrate AcCoA | — | 1.013 | 0.16 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), holo-ACP2: excised second acyl carrier protein domain of MycA, phosphopantetheinylated, N-terminally His6-tagged |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | holo-D-ACP2: excised docking domain-ACP2 didomain of MycA, phosphopantetheinylated, N-terminally His6-tagged | — | 0.005 | 20.5 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), holo-D-ACP2: excised docking domain-ACP2 didomain of MycA, phosphopantetheinylated, N-terminally His6-tagged |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | holo-KS-D-ACP2: excised ketosynthase-docking domain-ACP2 tridomain of MycA, phosphopantetheinylated, N-terminally His6-tagged | — | 0.47 | 24.4 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), holo-KS-D-ACP2: excised ketosynthase-docking domain-ACP2 tridomain of MycA, phosphopantetheinylated, N-terminally His6-tagged |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | holo-PCP1: excised first peptidyl carrier protein domain of MycA, phosphopantetheinylated, N-terminally His6-tagged | — | 0.84 | 1.7 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), holo-PCP1: excised first peptidyl carrier protein domain of MycA, phosphopantetheinylated, N-terminally His6-tagged |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | malonyl-coenzyme AFenF 4 nM; cosubstrate holo-ACP2 | 17 | 0.045 | 370 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), malonyl-coenzyme A |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | malonyl-coenzyme Acosubstrate holo-ACP1 | 15 | 0.11 | 140 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), malonyl-coenzyme A |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | malonyl-coenzyme Acosubstrate holo-PCP1 | 1.4 | 0.0308 | 47 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), malonyl-coenzyme A |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | malonyl-coenzyme Acosubstrate holo-D-ACP2 | 0.09 | 0.35 | 0.27 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), malonyl-coenzyme A |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | malonyl-coenzyme Acosubstrate holo-KS-D-ACP2 | 12 | 0.224 | 51 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), malonyl-coenzyme A |
| FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase) | Bacillus subtilis | methylmalonyl-coenzyme A | 0.073 | 0.36 | 0.2 | pH 8.25 | PMID 17330903 | Open record: FenF (free-standing malonyl acyltransferase of the mycosubtilin synthetase), methylmalonyl-coenzyme A |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | acetoacetyl-CoA | 7.3 | 8.6 × 10⁻⁴ | 8.5 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, acetoacetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | acetyl-CoAacyl-CoA varied 0.1-100 μM; holo-ACP (60 μM) | 13.7 | 0.00163 | 8.4 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, acetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | acetyl-CoAholo-ACP (varied, extrapolated) | 99.2 | 0.012 | 8.3 × 10³ calc. | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, acetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | acyl carrier protein (holo, murine FAS ACP domain) | — | 0.245 | — | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, acyl carrier protein (holo, murine FAS ACP domain) | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | butyryl-CoA | 10.8 | 0.00164 | 6.6 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, butyryl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | crotonyl-CoA | 6 | 0.00136 | 4.4 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, crotonyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | hydroxybutyryl-CoA | 6.1 | 0.00172 | 3.6 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, hydroxybutyryl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | malonyl-CoAacyl-CoA varied 0.1-100 μM; holo-ACP (60 μM) | 15.6 | 0.00128 | 1.22 × 10⁴ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, malonyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | malonyl-CoAholo-ACP (varied, extrapolated) | 119 | 0.0088 | 1.4 × 10⁴ calc. | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, malonyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | methylbutyryl-CoA | 7.2 | 0.00206 | 3.5 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, methylbutyryl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | methylmalonyl-CoA | 4 | 6.2 × 10⁻⁴ | 6.5 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, methylmalonyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | octanoyl-CoA | 4.1 | 7.3 × 10⁻⁴ | 5.6 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, octanoyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | palmitoyl-CoA | 2.5 | 0.0048 | 500 | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, palmitoyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | phenylacetyl-CoA | 6 | 9.6 × 10⁻⁴ | 6.2 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, phenylacetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | succinyl-CoA | 13.4 | 0.0021 | 6.4 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, succinyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G/R606A | Mus musculus | acetyl-CoA | 13 | 0.003 | 4 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G/R606A, acetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G/R606A | Mus musculus | malonyl-CoA | 5 | 0.018 | 300 | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G/R606A, malonyl-CoA |