EC 2.3.1.74: chalcone synthase

TransferasesOpen in Browse

CatLog read 79 records for EC 2.3.1.74 from 6 papers, for 5 organisms. Names in these papers: chalcone synthase (CHS2), chalcone synthase (GmCHS1), chalcone synthase CHS_H1, RinPKS1 (bifunctional type III polyketide synthase with chalcone synthase and benzalacetone synthase activity) and 1 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 47 records for EC 2.3.1.74 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.3.1.74 in Browse.

Papers

Papers with records for EC 2.3.1.74
Paper	Organisms	Records
Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity	Medicago sativa	39
Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase	Medicago sativa	26
Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis	Humulus lupulus	4
Structural insights into catalytic promiscuity of chalcone synthase from Glycine max (L.) Merr.: Coenzyme A-induced alteration of product specificity	Glycine max	4
doi:10.1007/s13562-016-0365-7	Rubus idaeus	4
Molecular architectures of benzoic acid-specific type III polyketide synthases	Malus × domestica	2

Records

Records for EC 2.3.1.74 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
chalcone synthase (CHS2)	Medicago sativa	3-Phenylpropionyl-CoA	0.0825	0.0049	16.84	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), 3-Phenylpropionyl-CoA
chalcone synthase (CHS2)	Medicago sativa	4-Methylcinnamoyl-CoA	0.0262	0.0034	7.696	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), 4-Methylcinnamoyl-CoA
chalcone synthase (CHS2)	Medicago sativa	Acetyl-CoA	0.0032	0.0084	0.376	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), Acetyl-CoA
chalcone synthase (CHS2)	Medicago sativa	Benzoyl-CoA	0.0288	0.0022	13.11	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), Benzoyl-CoA
chalcone synthase (CHS2)	Medicago sativa	Butyryl-CoA	0.0152	0.0042	3.611	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), Butyryl-CoA
chalcone synthase (CHS2)	Medicago sativa	Cinnamoyl-CoA	0.0793	0.005	15.9	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), Cinnamoyl-CoA
chalcone synthase (CHS2)	Medicago sativa	Feruloyl-CoA	0.0173	0.0052	3.33	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), Feruloyl-CoA
chalcone synthase (CHS2)	Medicago sativa	Heptanoyl-CoA	0.0505	0.004	12.63	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), Heptanoyl-CoA
chalcone synthase (CHS2)	Medicago sativa	Hexanoyl-CoA	0.042	0.0041	10.24	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), Hexanoyl-CoA
chalcone synthase (CHS2)	Medicago sativa	m-Coumaroyl-CoA	0.0583	0.0045	12.96	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), m-Coumaroyl-CoA
chalcone synthase (CHS2)	Medicago sativa	malonyl-coenzyme Anaringenin (chalcone) formation	0.0618	0.0041	15.08	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2), malonyl-coenzyme A
chalcone synthase (CHS2)	Medicago sativa	malonyl-coenzyme Aradiometric TLC assay with [14C]malonyl-CoA	0.06817	0.0191	3.57	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2), malonyl-coenzyme A
chalcone synthase (CHS2)	Medicago sativa	o-Coumaroyl-CoA	0.0387	0.0038	10.18	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), o-Coumaroyl-CoA
chalcone synthase (CHS2)	Medicago sativa	Octanoyl-CoA	0.0457	0.0038	12.02	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), Octanoyl-CoA
chalcone synthase (CHS2)	Medicago sativa	p-Coumaroyl-CoA	0.0857	0.0061	14.04	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), p-Coumaroyl-CoA
chalcone synthase (CHS2)	Medicago sativa	p-coumaroyl-coenzyme A	0.03683	0.0045	8.19	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2), p-coumaroyl-coenzyme A
chalcone synthase (CHS2)	Medicago sativa	Phenylacetyl-CoA	0.0362	0.0051	7.092	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), Phenylacetyl-CoA
chalcone synthase (CHS2)	Medicago sativa	Valeryl-CoA	0.031	0.0045	6.889	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2), Valeryl-CoA
chalcone synthase (CHS2)variant C164A	Medicago sativa	malonyl-coenzyme A	0.00692	0.0185	0.374	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant C164A, malonyl-coenzyme A
chalcone synthase (CHS2)variant C164S	Medicago sativa	malonyl-coenzyme A	0.00672	0.023	0.292	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant C164S, malonyl-coenzyme A
chalcone synthase (CHS2)variant F215A	Medicago sativa	N-methylanthraniloyl-CoA	0.0017	0.0207	0.08	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F215A, N-methylanthraniloyl-CoA
chalcone synthase (CHS2)variant F215S	Medicago sativa	Benzoyl-CoA	6.7 × 10⁻⁴	0.0038	0.175	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F215S, Benzoyl-CoA
chalcone synthase (CHS2)variant F215S	Medicago sativa	Heptanoyl-CoA	8.3 × 10⁻⁴	0.0054	0.154	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F215S, Heptanoyl-CoA
chalcone synthase (CHS2)variant F215S	Medicago sativa	Hexanoyl-CoA	0.0012	0.0045	0.272	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F215S, Hexanoyl-CoA
chalcone synthase (CHS2)variant F215S	Medicago sativa	malonyl-coenzyme Anaringenin (chalcone) formation	6.25 × 10⁻⁴	0.104	0.006	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant F215S, malonyl-coenzyme A
chalcone synthase (CHS2)variant F215S	Medicago sativa	malonyl-coenzyme Aradiometric TLC assay with [14C]malonyl-CoA	0.001247	0.0546	0.0228	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant F215S, malonyl-coenzyme A
chalcone synthase (CHS2)variant F215S	Medicago sativa	N-methylanthraniloyl-CoA	0.0015	0.003	0.5	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F215S, N-methylanthraniloyl-CoA
chalcone synthase (CHS2)variant F215S	Medicago sativa	Octanoyl-CoA	6.7 × 10⁻⁴	0.0048	0.15	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F215S, Octanoyl-CoA
chalcone synthase (CHS2)variant F215S	Medicago sativa	p-Coumaroyl-CoA	3.3 × 10⁻⁴	0.004	0.083	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F215S, p-Coumaroyl-CoA
chalcone synthase (CHS2)variant F215S	Medicago sativa	p-coumaroyl-coenzyme A	4.02 × 10⁻⁴	0.0038	0.106	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant F215S, p-coumaroyl-coenzyme A
chalcone synthase (CHS2)variant F215S	Medicago sativa	Phenylacetyl-CoA	6.7 × 10⁻⁴	0.0045	0.145	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F215S, Phenylacetyl-CoA
chalcone synthase (CHS2)variant F215S	Medicago sativa	Valeryl-CoA	6.7 × 10⁻⁴	0.0045	0.151	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F215S, Valeryl-CoA
chalcone synthase (CHS2)variant F215W	Medicago sativa	malonyl-coenzyme Anaringenin (chalcone) formation	2.25 × 10⁻⁴	0.107	0.0021	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant F215W, malonyl-coenzyme A
chalcone synthase (CHS2)variant F215W	Medicago sativa	malonyl-coenzyme Aradiometric TLC assay with [14C]malonyl-CoA	8.22 × 10⁻⁴	0.124	0.0079	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant F215W, malonyl-coenzyme A
chalcone synthase (CHS2)variant F215W	Medicago sativa	p-coumaroyl-coenzyme A	3.4 × 10⁻⁴	0.0304	0.0111	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant F215W, p-coumaroyl-coenzyme A
chalcone synthase (CHS2)variant F215Y	Medicago sativa	malonyl-coenzyme Anaringenin (chalcone) formation	3.35 × 10⁻⁴	0.184	0.0018	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant F215Y, malonyl-coenzyme A
chalcone synthase (CHS2)variant F215Y	Medicago sativa	malonyl-coenzyme Aradiometric TLC assay with [14C]malonyl-CoA	0.00285	0.0636	0.0448	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant F215Y, malonyl-coenzyme A
chalcone synthase (CHS2)variant F215Y	Medicago sativa	p-coumaroyl-coenzyme A	6.47 × 10⁻⁴	0.0183	0.0353	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant F215Y, p-coumaroyl-coenzyme A
chalcone synthase (CHS2)variant F265V	Medicago sativa	3-Phenylpropionyl-CoA	0.0733	0.0138	5.314	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, 3-Phenylpropionyl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	4-Methylcinnamoyl-CoA	0.0137	0.0074	1.846	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, 4-Methylcinnamoyl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	Acetyl-CoA	0.0065	0.0086	0.755	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, Acetyl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	Benzoyl-CoA	0.0213	0.0047	7.907	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, Benzoyl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	Butyryl-CoA	0.0093	0.0052	1.794	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, Butyryl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	Cinnamoyl-CoA	0.0278	0.0171	1.628	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, Cinnamoyl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	Feruloyl-CoA	0.0405	0.009	4.5	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, Feruloyl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	Heptanoyl-CoA	0.1097	0.0078	14.06	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, Heptanoyl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	Hexanoyl-CoA	0.0593	0.005	11.9	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, Hexanoyl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	m-Coumaroyl-CoA	0.0278	0.0055	5.06	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, m-Coumaroyl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	o-Coumaroyl-CoA	0.0078	0.004	1.958	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, o-Coumaroyl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	Octanoyl-CoA	0.1637	0.0056	29.23	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, Octanoyl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	p-Coumaroyl-CoA	0.0335	0.005	6.7	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, p-Coumaroyl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	Phenylacetyl-CoA	0.0728	0.0057	12.78	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, Phenylacetyl-CoA
chalcone synthase (CHS2)variant F265V	Medicago sativa	Valeryl-CoA	0.0222	0.0061	3.634	pH 7, 25 °C	PMID 11959984	Open record: chalcone synthase (CHS2) variant F265V, Valeryl-CoA
chalcone synthase (CHS2)variant H303Q	Medicago sativa	malonyl-coenzyme Anaringenin (chalcone) formation	0.00927	0.0082	1.13	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant H303Q, malonyl-coenzyme A
chalcone synthase (CHS2)variant H303Q	Medicago sativa	malonyl-coenzyme Aradiometric TLC assay with [14C]malonyl-CoA	0.01097	0.0252	0.435	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant H303Q, malonyl-coenzyme A
chalcone synthase (CHS2)variant H303Q	Medicago sativa	p-coumaroyl-coenzyme A	0.00482	0.0076	0.634	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant H303Q, p-coumaroyl-coenzyme A
chalcone synthase (CHS2)variant N336A	Medicago sativa	malonyl-coenzyme Anaringenin (chalcone) formation	1.32 × 10⁻⁴	0.0419	0.0031	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant N336A, malonyl-coenzyme A
chalcone synthase (CHS2)variant N336A	Medicago sativa	malonyl-coenzyme Aradiometric TLC assay with [14C]malonyl-CoA	4.82 × 10⁻⁴	0.0678	0.0071	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant N336A, malonyl-coenzyme A
chalcone synthase (CHS2)variant N336A	Medicago sativa	p-coumaroyl-coenzyme A	5.28 × 10⁻⁴	0.0058	0.091	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant N336A, p-coumaroyl-coenzyme A
chalcone synthase (CHS2)variant N336D	Medicago sativa	malonyl-coenzyme Anaringenin (chalcone) formation	1.2 × 10⁻⁵	0.0332	3 × 10⁻⁴	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant N336D, malonyl-coenzyme A
chalcone synthase (CHS2)variant N336D	Medicago sativa	malonyl-coenzyme Aradiometric TLC assay with [14C]malonyl-CoA	2.32 × 10⁻⁴	0.159	0.0015	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant N336D, malonyl-coenzyme A
chalcone synthase (CHS2)variant N336D	Medicago sativa	p-coumaroyl-coenzyme A	2.2 × 10⁻⁵	0.0183	0.0012	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant N336D, p-coumaroyl-coenzyme A
chalcone synthase (CHS2)variant N336K	Medicago sativa	malonyl-coenzyme Anaringenin (chalcone) formation	4.3 × 10⁻⁵	0.127	3 × 10⁻⁴	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant N336K, malonyl-coenzyme A
chalcone synthase (CHS2)variant N336K	Medicago sativa	malonyl-coenzyme Aradiometric TLC assay with [14C]malonyl-CoA	2.25 × 10⁻⁴	0.339	7 × 10⁻⁴	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant N336K, malonyl-coenzyme A
chalcone synthase (CHS2)variant N336K	Medicago sativa	p-coumaroyl-coenzyme A	1.2 × 10⁻⁵	0.0281	4 × 10⁻⁴	pH 7, 25 °C	PMID 10653632	Open record: chalcone synthase (CHS2) variant N336K, p-coumaroyl-coenzyme A
chalcone synthase (GmCHS1)	Glycine max	p-coumaroyl-coenzyme A	0.0617	0.00771	8		PMID 38735137	Open record: chalcone synthase (GmCHS1), p-coumaroyl-coenzyme A
chalcone synthase (GmCHS1)variant K268A	Glycine max	p-coumaroyl-coenzyme A	0.0517	0.012	4.3		PMID 38735137	Open record: chalcone synthase (GmCHS1) variant K268A, p-coumaroyl-coenzyme A
chalcone synthase (GmCHS1)variant K55A	Glycine max	p-coumaroyl-coenzyme A	0.109	0.00333	33		PMID 38735137	Open record: chalcone synthase (GmCHS1) variant K55A, p-coumaroyl-coenzyme A
chalcone synthase (GmCHS1)variant R58A	Glycine max	p-coumaroyl-coenzyme A	—	—	20		PMID 38735137	Open record: chalcone synthase (GmCHS1) variant R58A, p-coumaroyl-coenzyme A
chalcone synthase CHS_H1	Humulus lupulus	Malonyl-CoACHS_H1 alone (no CHIL2)	2.4 × 10⁻⁴	0.01006	0.024	pH 7, 30 °C	PMID 29760092	Open record: chalcone synthase CHS_H1, Malonyl-CoA
chalcone synthase CHS_H1	Humulus lupulus	Malonyl-CoA	0.0042	0.05974	0.07	pH 7, 30 °C	PMID 29760092	Open record: chalcone synthase CHS_H1, Malonyl-CoA
chalcone synthase CHS_H1	Humulus lupulus	p-Coumaroyl-CoACHS_H1 alone (no CHIL2)	2.1 × 10⁻⁴	0.00482	0.044	pH 7, 30 °C	PMID 29760092	Open record: chalcone synthase CHS_H1, p-Coumaroyl-CoA
chalcone synthase CHS_H1	Humulus lupulus	p-Coumaroyl-CoA	0.0012	0.02657	0.045	pH 7, 30 °C	PMID 29760092	Open record: chalcone synthase CHS_H1, p-Coumaroyl-CoA
chalcone synthase MdCHS2	Malus × domestica	4-coumaroyl-CoA	0.02	0.0179	1.117	pH 7, 37 °C	PMID 29199980	Open record: chalcone synthase MdCHS2, 4-coumaroyl-CoA
chalcone synthase MdCHS2	Malus × domestica	malonyl-CoA	—	0.0128	—	pH 7, 37 °C	PMID 29199980	Open record: chalcone synthase MdCHS2, malonyl-CoA
RinPKS1 (bifunctional type III polyketide synthase with chalcone synthase and benzalacetone synthase activity)	Rubus idaeus	4-coumaroyl-CoA	0.045	0.01642	2.742	pH 7.5, 35 °C	doi:10.1007/s13562-016-0365-7	Open record: RinPKS1 (bifunctional type III polyketide synthase with chalcone synthase and benzalacetone synthase activity), 4-coumaroyl-CoA
RinPKS1 (bifunctional type III polyketide synthase with chalcone synthase and benzalacetone synthase activity)	Rubus idaeus	4-coumaroyl-CoA	0.0108	0.01289	0.84	pH 9.5, 35 °C	doi:10.1007/s13562-016-0365-7	Open record: RinPKS1 (bifunctional type III polyketide synthase with chalcone synthase and benzalacetone synthase activity), 4-coumaroyl-CoA
RinPKS1 (bifunctional type III polyketide synthase with chalcone synthase and benzalacetone synthase activity)	Rubus idaeus	malonyl-CoA	0.0713	0.02283	3.122	pH 7.5, 35 °C	doi:10.1007/s13562-016-0365-7	Open record: RinPKS1 (bifunctional type III polyketide synthase with chalcone synthase and benzalacetone synthase activity), malonyl-CoA
RinPKS1 (bifunctional type III polyketide synthase with chalcone synthase and benzalacetone synthase activity)	Rubus idaeus	malonyl-CoA	0.0077	0.04117	0.186	pH 9.5, 35 °C	doi:10.1007/s13562-016-0365-7	Open record: RinPKS1 (bifunctional type III polyketide synthase with chalcone synthase and benzalacetone synthase activity), malonyl-CoA