EC 2.3.1.81: aminoglycoside 3-N-acetyltransferase
TransferasesOpen in Browse
CatLog read 38 records for EC 2.3.1.81 from 3 papers, for 2 organisms. Names in these papers: AAC(6’)-APH(2’’), aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA), AAC(3)-XI (aminoglycoside 3-N-acetyltransferase type XI).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 30 records for EC 2.3.1.81 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.3.1.81 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides | — | 23 |
| Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa | Pseudomonas aeruginosa | 12 |
| AAC(3)-XI, a new aminoglycoside 3-N-acetyltransferase from Corynebacterium striatum | Corynebacterium striatum | 3 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| AAC(3)-XI (aminoglycoside 3-N-acetyltransferase type XI) | Corynebacterium striatum | acetyl coenzyme A | 0.24 | 0.0027 | 89 | pH 6 | PMID 26149994 | Open record: AAC(3)-XI (aminoglycoside 3-N-acetyltransferase type XI), acetyl coenzyme A |
| AAC(3)-XI (aminoglycoside 3-N-acetyltransferase type XI) | Corynebacterium striatum | dibekacin | 0.17 | 0.0092 | 18 | pH 6 | PMID 26149994 | Open record: AAC(3)-XI (aminoglycoside 3-N-acetyltransferase type XI), dibekacin |
| AAC(3)-XI (aminoglycoside 3-N-acetyltransferase type XI) | Corynebacterium striatum | kanamycin B | 0.23 | 0.0138 | 17 | pH 6 | PMID 26149994 | Open record: AAC(3)-XI (aminoglycoside 3-N-acetyltransferase type XI), kanamycin B |
| AAC(6’)-APH(2’’) | — | acetyl-coenzyme Avaried acetyl-CoA at fixed kanamycin A | 0.012 | 0.002 | 24 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), acetyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | acetyl-coenzyme Avaried acetyl-CoA at fixed kanamycin A | 0.163 | 0.0033 | 50 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), acetyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | acetyl-coenzyme Avaried acetyl-CoA at fixed kanamycin A | 0.559 | 0.0099 | 56 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), acetyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | acetyl-coenzyme Avaried acetyl-CoA at fixed kanamycin A | 0.3 | 0.0055 | 55 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), acetyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | acetyl-coenzyme Avaried acetyl-CoA at fixed kanamycin A | 0.075 | 0.0028 | 27 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), acetyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | acetyl-coenzyme Avaried acetyl-CoA at fixed amikacin; cosubstrate amikacin | 0.126 | 9.6 × 10⁻⁴ | 131 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), acetyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | acetyl-coenzyme Avaried acetyl-CoA at fixed gentamicin | 0.182 | 0.0046 | 40 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), acetyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | acetyl-coenzyme Avaried acetyl-CoA at fixed neomycin B | 0.188 | 0.0148 | 13 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), acetyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | acetyl-coenzyme Avaried acetyl-CoA at fixed sisomicin; cosubstrate sisomicin | 0.173 | 0.0015 | 112 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), acetyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | acetyl-coenzyme Avaried acetyl-CoA at fixed tobramycin | 0.179 | 0.0027 | 66 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), acetyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | kanamycin A | 0.034 | 4 × 10⁻⁴ | 87 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), kanamycin A |
| AAC(6’)-APH(2’’) | — | malonyl-coenzyme Avaried malonyl-CoA at fixed amikacin; cosubstrate amikacin | 0.146 | 0.0716 | 2 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), malonyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | malonyl-coenzyme Avaried malonyl-CoA at fixed gentamicin | 0.041 | 0.0189 | 2 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), malonyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | n-propionyl-coenzyme Akanamycin A; cosubstrate kanamycin A | 0.017 | 0.0048 | 3 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), n-propionyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | n-propionyl-coenzyme Akanamycin A; cosubstrate kanamycin A | 0.044 | 0.0091 | 5 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), n-propionyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | n-propionyl-coenzyme Akanamycin A; cosubstrate kanamycin A | 0.144 | 0.0135 | 11 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), n-propionyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | n-propionyl-coenzyme Akanamycin A; cosubstrate kanamycin A | 0.134 | 0.0111 | 12 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), n-propionyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | n-propionyl-coenzyme Aamikacin; cosubstrate amikacin; C-terminal His6 tag (pET22b) | 0.124 | 0.0021 | 60 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), n-propionyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | n-propionyl-coenzyme Agentamicin; cosubstrate gentamicin | 0.123 | 0.0029 | 43 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), n-propionyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | n-propionyl-coenzyme Aneomycin B; cosubstrate neomycin B | 0.076 | 0.0031 | 24 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), n-propionyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | n-propionyl-coenzyme Asisomicin; cosubstrate sisomicin | 0.121 | 5.7 × 10⁻⁴ | 211 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), n-propionyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | n-propionyl-coenzyme Atobramycin; cosubstrate tobramycin | 0.089 | 0.0054 | 16 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), n-propionyl-coenzyme A |
| AAC(6’)-APH(2’’) | — | sisomicin | 0.382 | 0.0059 | 65 | pH 6.6 | PMID 19899089 | Open record: AAC(6’)-APH(2’’), sisomicin |
| aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA) | Pseudomonas aeruginosa | gentamicin | 6.12 | 0.0071 | 860 | pH 6.5, 22 °C | PMID 35921328 | Open record: aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA), gentamicin |
| aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA) | Pseudomonas aeruginosa | Gentamicin | 8.18 | 0.0101 | 810 | pH 6.5, 22 °C | PMID 35921328 | Open record: aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA), Gentamicin |
| aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA) | Pseudomonas aeruginosa | Kanamycin | 4.45 | 0.007 | 630 | pH 6.5, 22 °C | PMID 35921328 | Open record: aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA), Kanamycin |
| aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA) | Pseudomonas aeruginosa | Neomycin | 6.15 | 0.0066 | 930 | pH 6.5, 22 °C | PMID 35921328 | Open record: aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA), Neomycin |
| aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA) | Pseudomonas aeruginosa | Paromomycin | 5.52 | 0.0067 | 820 | pH 6.5, 22 °C | PMID 35921328 | Open record: aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA), Paromomycin |
| aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA) | Pseudomonas aeruginosa | Ribostamycin | 5.38 | 0.0079 | 680 | pH 6.5, 22 °C | PMID 35921328 | Open record: aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA), Ribostamycin |
| aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA) | Pseudomonas aeruginosa | Sisomicin | 10.48 | 0.0109 | 970 | pH 6.5, 22 °C | PMID 35921328 | Open record: aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA), Sisomicin |
| aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA) | Pseudomonas aeruginosa | Tobramycin | 5.68 | 0.0066 | 860 | pH 6.5, 22 °C | PMID 35921328 | Open record: aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA), Tobramycin |
| aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA)variant D170F | Pseudomonas aeruginosa | gentamicin | 3.4 | 0.0047 | 720 | pH 6.5, 22 °C | PMID 35921328 | Open record: aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA) variant D170F, gentamicin |
| aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA)variant D72W | Pseudomonas aeruginosa | gentamicin | 3.59 | 0.019 | 190 | pH 6.5, 22 °C | PMID 35921328 | Open record: aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA) variant D72W, gentamicin |
| aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA)variant Y146F | Pseudomonas aeruginosa | gentamicin | 4.33 | 0.0085 | 510 | pH 6.5, 22 °C | PMID 35921328 | Open record: aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA) variant Y146F, gentamicin |
| aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA)variant Y64F | Pseudomonas aeruginosa | gentamicin | 12.5 | 0.0143 | 870 | pH 6.5, 22 °C | PMID 35921328 | Open record: aminoglycoside acetyltransferase (3)-IIIa (AAC(3)-IIIa, isoA) variant Y64F, gentamicin |