EC 2.4.2.22: xanthine phosphoribosyltransferase
TransferasesOpen in Browse
CatLog read 54 records for EC 2.4.2.22 from 3 papers, for 3 organisms. Names in these papers: xanthine phosphoribosyltransferase (LdXPRT), hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase), xanthine phosphoribosyltransferase (XPRT).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 17 records for EC 2.4.2.22 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.4.2.22 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Acidic residues in the purine binding site govern the 6-oxopurine specificity of the Leishmania donovani xanthine phosphoribosyltransferase | Leishmania donovani | 38 |
| Role of the flexible loop of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus in enzyme catalysis | Tritrichomonas foetus | 12 |
| Crystal structure of Escherichia coli xanthine phosphoribosyltransferase | Escherichia coli | 4 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) | Tritrichomonas foetus | alpha-D-5-phosphoribosyl-1-pyrophosphate | — | 0.046 | — | pH 7, 37 °C | PMID 11284686 | Open record: hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase), alpha-D-5-phosphoribosyl-1-pyrophosphate |
| hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) | Tritrichomonas foetus | guanine | 2.5 | 0.0024 | 1.0 × 10³ calc. | pH 7, 37 °C | PMID 11284686 | Open record: hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase), guanine |
| hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase)variant S73A | Tritrichomonas foetus | alpha-D-5-phosphoribosyl-1-pyrophosphate | — | 0.1941 | — | pH 7, 37 °C | PMID 11284686 | Open record: hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) variant S73A, alpha-D-5-phosphoribosyl-1-pyrophosphate |
| hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase)variant S73A | Tritrichomonas foetus | guanine | 2.3 | 0.0112 | 210 calc. | pH 7, 37 °C | PMID 11284686 | Open record: hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) variant S73A, guanine |
| hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase)variant S75H | Tritrichomonas foetus | alpha-D-5-phosphoribosyl-1-pyrophosphate | — | 0.0287 | — | pH 7, 37 °C | PMID 11284686 | Open record: hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) variant S75H, alpha-D-5-phosphoribosyl-1-pyrophosphate |
| hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase)variant S75H | Tritrichomonas foetus | guanine | 3.3 | 0.0029 | 1.1 × 10³ calc. | pH 7, 37 °C | PMID 11284686 | Open record: hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) variant S75H, guanine |
| hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase)variant Y74E | Tritrichomonas foetus | alpha-D-5-phosphoribosyl-1-pyrophosphate | — | 0.2068 | — | pH 7, 37 °C | PMID 11284686 | Open record: hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) variant Y74E, alpha-D-5-phosphoribosyl-1-pyrophosphate |
| hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase)variant Y74E | Tritrichomonas foetus | guanine | 1.5 | 0.0164 | 91 calc. | pH 7, 37 °C | PMID 11284686 | Open record: hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) variant Y74E, guanine |
| hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase)variant Y74F | Tritrichomonas foetus | alpha-D-5-phosphoribosyl-1-pyrophosphate | — | 0.1385 | — | pH 7, 37 °C | PMID 11284686 | Open record: hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) variant Y74F, alpha-D-5-phosphoribosyl-1-pyrophosphate |
| hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase)variant Y74F | Tritrichomonas foetus | guanine | 1.8 | 0.0145 | 120 calc. | pH 7, 37 °C | PMID 11284686 | Open record: hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) variant Y74F, guanine |
| hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase)variant Y74W | Tritrichomonas foetus | alpha-D-5-phosphoribosyl-1-pyrophosphate | — | 0.0412 | — | pH 7, 37 °C | PMID 11284686 | Open record: hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) variant Y74W, alpha-D-5-phosphoribosyl-1-pyrophosphate |
| hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase)variant Y74W | Tritrichomonas foetus | guanine | 3.1 | 0.0043 | 720 calc. | pH 7, 37 °C | PMID 11284686 | Open record: hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) variant Y74W, guanine |
| xanthine phosphoribosyltransferase (LdXPRT) | Leishmania donovani | 5-phosphoribosyl-1-pyrophosphate10 mM MgCl2; hypoxanthine fixed at 1.0 mM | 3.9 | 0.0288 | 140 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT), 5-phosphoribosyl-1-pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT) | Leishmania donovani | 5-phosphoribosyl-1-pyrophosphate10 mM MgCl2; xanthine fixed at 1.0 mM; cosubstrate xanthine | 3.9 | 0.0162 | 240 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT), 5-phosphoribosyl-1-pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT) | Leishmania donovani | 5-phosphoribosyl-1-pyrophosphate5 mM MnCl2 in place of MgCl2; xanthine fixed at 1.0 mM | — | 0.068 | — | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT), 5-phosphoribosyl-1-pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT) | Leishmania donovani | hypoxanthine10 mM MgCl2; nucleobase concentration varied | 3.1 | 0.458 | 6.8 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT), hypoxanthine |
| xanthine phosphoribosyltransferase (LdXPRT) | Leishmania donovani | hypoxanthine5 mM MnCl2 in place of MgCl2; hypoxanthine varied | — | 0.151 | — | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT), hypoxanthine |
| xanthine phosphoribosyltransferase (LdXPRT) | Leishmania donovani | pyrophosphate | 0.0228 | 0.039 | 0.59 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT), pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT) | Leishmania donovani | xanthine | 3.5 | 0.0073 | 480 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT), xanthine |
| xanthine phosphoribosyltransferase (LdXPRT) | Leishmania donovani | XMP | 0.028 | 0.092 | 0.31 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT), XMP |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D | Leishmania donovani | 5-phosphoribosyl-1-pyrophosphatehypoxanthine fixed at 1.0 mM; cosubstrate hypoxanthine | 8.4 | 0.0251 | 330 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D, 5-phosphoribosyl-1-pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D | Leishmania donovani | 5-phosphoribosyl-1-pyrophosphatexanthine fixed at 1.0 mM; cosubstrate xanthine | 20.7 | 0.0382 | 542 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D, 5-phosphoribosyl-1-pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D | Leishmania donovani | guanine | 3.3 | — | — | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D, guanine |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D | Leishmania donovani | hypoxanthine | 7.1 | 0.567 | 13 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D, hypoxanthine |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D | Leishmania donovani | pyrophosphate | 0.0093 | 0.133 | 0.070 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D, pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D | Leishmania donovani | xanthine | 23.3 | 0.0078 | 3.0 × 10³ calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D, xanthine |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D | Leishmania donovani | XMP | 0.0103 | 0.358 | 0.0290 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D, XMP |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D/E215D | Leishmania donovani | 5-phosphoribosyl-1-pyrophosphatehypoxanthine fixed at 1.0 mM; cosubstrate hypoxanthine | 3.6 | 0.0034 | 1.1 × 10³ calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D/E215D, 5-phosphoribosyl-1-pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D/E215D | Leishmania donovani | 5-phosphoribosyl-1-pyrophosphatexanthine fixed at 1.0 mM; cosubstrate xanthine | 12.3 | 0.0073 | 1.7 × 10³ calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D/E215D, 5-phosphoribosyl-1-pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D/E215D | Leishmania donovani | guanine | 1.1 | 0.0049 | 220 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D/E215D, guanine |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D/E215D | Leishmania donovani | hypoxanthine | 2.2 | 0.0021 | 1.0 × 10³ calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D/E215D, hypoxanthine |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D/E215D | Leishmania donovani | IMP | 0.0062 | 0.0078 | 0.79 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D/E215D, IMP |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D/E215D | Leishmania donovani | pyrophosphateIMP fixed at 8.0 mM; cosubstrate IMP | 0.0045 | 0.074 | 0.061 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D/E215D, pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D/E215D | Leishmania donovani | pyrophosphateXMP fixed at 1.0 mM; cosubstrate XMP | 0.0118 | 0.0059 | 2.0 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D/E215D, pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D/E215D | Leishmania donovani | xanthine | 16.4 | 0.0913 | 180 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D/E215D, xanthine |
| xanthine phosphoribosyltransferase (LdXPRT)variant E198D/E215D | Leishmania donovani | XMP | 0.0148 | 0.533 | 0.0280 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E198D/E215D, XMP |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215D | Leishmania donovani | 5-phosphoribosyl-1-pyrophosphatehypoxanthine fixed at 1.0 mM; cosubstrate hypoxanthine | 6.7 | 0.0181 | 370 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215D, 5-phosphoribosyl-1-pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215D | Leishmania donovani | 5-phosphoribosyl-1-pyrophosphatexanthine fixed at 1.0 mM; cosubstrate xanthine | 15.1 | 0.0244 | 619 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215D, 5-phosphoribosyl-1-pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215D | Leishmania donovani | guanine | 1.5 | — | — | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215D, guanine |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215D | Leishmania donovani | hypoxanthine | 8.7 | 0.524 | 17 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215D, hypoxanthine |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215D | Leishmania donovani | pyrophosphate | 0.0038 | 0.115 | 0.033 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215D, pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215D | Leishmania donovani | xanthine | 17.5 | 0.0199 | 879 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215D, xanthine |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215D | Leishmania donovani | XMP | 0.0037 | 0.396 | 0.0093 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215D, XMP |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215Q | Leishmania donovani | 5-phosphoribosyl-1-pyrophosphatehypoxanthine fixed at 1.0 mM; cosubstrate hypoxanthine | 2.1 | 0.023 | 91 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215Q, 5-phosphoribosyl-1-pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215Q | Leishmania donovani | 5-phosphoribosyl-1-pyrophosphatexanthine fixed at 1.0 mM; cosubstrate xanthine | 2.6 | 0.045 | 58 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215Q, 5-phosphoribosyl-1-pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215Q | Leishmania donovani | guanine | 0.1 | 0.025 | 4.0 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215Q, guanine |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215Q | Leishmania donovani | hypoxanthine | 2.4 | 0.129 | 19 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215Q, hypoxanthine |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215Q | Leishmania donovani | pyrophosphate | 0.025 | 0.028 | 0.89 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215Q, pyrophosphate |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215Q | Leishmania donovani | xanthine | 2 | 0.035 | 57 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215Q, xanthine |
| xanthine phosphoribosyltransferase (LdXPRT)variant E215Q | Leishmania donovani | XMP | 0.043 | 0.094 | 0.46 calc. | pH 7.5, 25 °C | PMID 19861168 | Open record: xanthine phosphoribosyltransferase (LdXPRT) variant E215Q, XMP |
| xanthine phosphoribosyltransferase (XPRT) | Escherichia coli | 5-phospho-alpha-D-ribosyl 1-pyrophosphate | 112 | 0.139 | 8.1 × 10³ | pH 8.5, 25 °C | PMID 9100006 | Open record: xanthine phosphoribosyltransferase (XPRT), 5-phospho-alpha-D-ribosyl 1-pyrophosphate |
| xanthine phosphoribosyltransferase (XPRT) | Escherichia coli | guanine | 112 | 0.0043 | 2.6 × 10⁴ | pH 8.5, 25 °C | PMID 9100006 | Open record: xanthine phosphoribosyltransferase (XPRT), guanine |
| xanthine phosphoribosyltransferase (XPRT) | Escherichia coli | hypoxanthine | 54.8 | 0.0908 | 600 | pH 8.5, 25 °C | PMID 9100006 | Open record: xanthine phosphoribosyltransferase (XPRT), hypoxanthine |
| xanthine phosphoribosyltransferase (XPRT) | Escherichia coli | xanthine | 150.1 | 0.0305 | 4.9 × 10³ | pH 8.5, 25 °C | PMID 9100006 | Open record: xanthine phosphoribosyltransferase (XPRT), xanthine |