EC 2.4.2.28: S-methyl-5'-thioadenosine phosphorylase

TransferasesOpen in Browse

CatLog read 67 records for EC 2.4.2.28 from 4 papers, for 4 organisms. Names in these papers: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP), 5'-methylthioadenosine phosphorylase (LiMTAP), 5'-methylthioadenosine/5'-deoxyadenosine phosphorylase MtnP (RrMtnP).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 43 records for EC 2.4.2.28 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.4.2.28 in Browse.

Papers

Papers with records for EC 2.4.2.28
PaperOrganismsRecords
Design, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substratesHomo sapiens34
Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5'-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage PathwaySchistosoma mansoni28
Repurposing approved drugs targeting Leishmania infantum 5-Methylthioadenosine Phosphorylase as anti-leishmanial candidatesLeishmania infantum4
A bifunctional salvage pathway for two distinct S-adenosylmethionine by-products that is widespread in bacteria, including pathogenic Escherichia coliRhodospirillum rubrum1

Records

Records for EC 2.4.2.28 read from the paper
EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaperOpen record
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapiens5'-deoxy-5'-methylthioadenosine4.60.00183.2 × 10³37 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), 5'-deoxy-5'-methylthioadenosine
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 102.30.003174037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 10
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 115.90.0041.48 × 10³37 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 11
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 121.460.0255837 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 12
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 130.850.0175037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 13
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 145.50.00281.96 × 10³37 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 14
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 154.20.00584037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 15
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 160.238.8 × 10⁻⁴26037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 16
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 173.440.005266037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 17
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 183.160.006946037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 18
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 191.50.00350037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 19
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 2 (R5' = H, R3' = OH, R2' = OH)4.80.00680037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 2 (R5' = H, R3' = OH, R2' = OH)
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 203.80.00942037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 20
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 212.490.003473037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 21
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 222.50.004653037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 22
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 232.140.00543037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 23
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 241.010.01029037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 24
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 251.570.003545037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 25
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 261.50.003247037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 26
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 270.80.00711037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 27
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 280.30.001717037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 28
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 291.40.001593037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 29
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 3 (R5' = CH3S, R3' = OH, R2' = H)0.280.00319037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 3 (R5' = CH3S, R3' = OH, R2' = H)
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 302.40.0021.2 × 10³37 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 30
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 310.180.00563037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 31
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 321.110.0129037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 32
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 332.020.008524037 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 33
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 344.60.00133.5 × 10³37 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 34
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 4 (R5' = CH3S, R3' = H, R2' = OH)0.0040.0039137 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 4 (R5' = CH3S, R3' = H, R2' = OH)
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 5 (R5' = CH3S, R3' = OH, R2' = F)4 × 10⁻⁴——37 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 5 (R5' = CH3S, R3' = OH, R2' = F)
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 6 (R5' = CH3S, R3' = OH, R2' = N3)0.043.60.01137 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 6 (R5' = CH3S, R3' = OH, R2' = N3)
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 7 (R5' = CH3S, R3' = OH, R2' = OH, stereochemistry R)0.00650.1060.137 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 7 (R5' = CH3S, R3' = OH, R2' = OH, stereochemistry R)
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 8 (R5' = CH3S, R3' = OH, R2' = NH2)0.670.032237 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 8 (R5' = CH3S, R3' = OH, R2' = NH2)
5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP)Homo sapienscompound 9 (ETA)2.90.00181.6 × 10³37 °CPMID 15911263Open record: 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP), compound 9 (ETA)
5'-methylthioadenosine phosphorylase (LiMTAP)Leishmania infantum5'-methylthioadenosineMTA varied 0-250 µM; 5% DMSO; apparent kcat; apparent Km0.3070.27911.10 calc.pH 7.4, 37 °CPMID 41909839Open record: 5'-methylthioadenosine phosphorylase (LiMTAP), 5'-methylthioadenosine
5'-methylthioadenosine phosphorylase (LiMTAP)Leishmania infantum5'-methylthioadenosineMTA varied; apparent kcat; apparent Km0.0720.04041.8 calc.pH 7.4, 37 °CPMID 41909839Open record: 5'-methylthioadenosine phosphorylase (LiMTAP), 5'-methylthioadenosine
5'-methylthioadenosine phosphorylase (LiMTAP)Leishmania infantum5'-methylthioadenosineMTA varied 0-250 µM; 5% DMSO; apparent kcat/Km——1.1pH 7.4, 37 °CPMID 41909839Open record: 5'-methylthioadenosine phosphorylase (LiMTAP), 5'-methylthioadenosine
5'-methylthioadenosine phosphorylase (LiMTAP)Leishmania infantum5'-methylthioadenosineMTA varied; apparent kcat/Km——1.77pH 7.4, 37 °CPMID 41909839Open record: 5'-methylthioadenosine phosphorylase (LiMTAP), 5'-methylthioadenosine
5'-methylthioadenosine/5'-deoxyadenosine phosphorylase MtnP (RrMtnP)Rhodospirillum rubrumadenosine0.060.0411.430 °CPMID 31950558Open record: 5'-methylthioadenosine/5'-deoxyadenosine phosphorylase MtnP (RrMtnP), adenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)Schistosoma mansoni2'-deoxyadenosine224.30.003975.649 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP), 2'-deoxyadenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)Schistosoma mansoni5'-deoxy-5'-methylthioadenosine443.80.003631.223 × 10⁵pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP), 5'-deoxy-5'-methylthioadenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)Schistosoma mansoniadenosine100 mM potassium phosphate buffer pH 7.4334.10.003141.064 × 10⁵pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP), adenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)Schistosoma mansoniadenosine100 mM Hepes pH 7.4175.90.00463.823 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP), adenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)Schistosoma mansoniphosphate477.60.065587.28 × 10³pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP), phosphate
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant N87TSchistosoma mansoni2'-deoxyadenosine441.20.010334.271 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant N87T, 2'-deoxyadenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant N87TSchistosoma mansoni5'-deoxy-5'-methylthioadenosine84.627.1 × 10⁻⁴1.192 × 10⁵pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant N87T, 5'-deoxy-5'-methylthioadenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant N87TSchistosoma mansoniadenosine100 mM potassium phosphate buffer pH 7.462.630.00331.897 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant N87T, adenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant N87TSchistosoma mansoniadenosine100 mM Hepes pH 7.4616.20.008866.954 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant N87T, adenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant N87TSchistosoma mansoniphosphate392.40.05616.99 × 10³pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant N87T, phosphate
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant Q289LSchistosoma mansoni2'-deoxyadenosine80.030.003022.65 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant Q289L, 2'-deoxyadenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant Q289LSchistosoma mansoni5'-deoxy-5'-methylthioadenosine241.60.002499.702 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant Q289L, 5'-deoxy-5'-methylthioadenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant Q289LSchistosoma mansoniadenosine95.790.001815.458 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant Q289L, adenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant Q289LSchistosoma mansoniphosphate50.320.2881170pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant Q289L, phosphate
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12TSchistosoma mansoni2'-deoxyadenosine48.449.9 × 10⁻⁴4.892 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T, 2'-deoxyadenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12TSchistosoma mansoni5'-deoxy-5'-methylthioadenosine145.10.001221.189 × 10⁵pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T, 5'-deoxy-5'-methylthioadenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12TSchistosoma mansoniadenosine98.420.00214.686 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T, adenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12TSchistosoma mansoniphosphate116.110.3711pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T, phosphate
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12T/N87TSchistosoma mansoni2'-deoxyadenosine372.80.003899.583 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T/N87T, 2'-deoxyadenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12T/N87TSchistosoma mansoni5'-deoxy-5'-methylthioadenosine416.20.002121.963 × 10⁵pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T/N87T, 5'-deoxy-5'-methylthioadenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12T/N87TSchistosoma mansoniadenosine100 mM potassium phosphate buffer pH 7.4308.90.003688.394 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T/N87T, adenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12T/N87TSchistosoma mansoniadenosine100 mM Hepes pH 7.4160.50.038744.14 × 10³pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T/N87T, adenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12T/N87TSchistosoma mansoniphosphate524.20.14263.67 × 10³pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T/N87T, phosphate
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12T/N87T/Q289LSchistosoma mansoni2'-deoxyadenosine299.20.006524.588 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T/N87T/Q289L, 2'-deoxyadenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12T/N87T/Q289LSchistosoma mansoni5'-deoxy-5'-methylthioadenosine253.90.003128.137 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T/N87T/Q289L, 5'-deoxy-5'-methylthioadenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12T/N87T/Q289LSchistosoma mansoniadenosine100 mM potassium phosphate buffer pH 7.4280.30.007353.813 × 10⁴pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T/N87T/Q289L, adenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12T/N87T/Q289LSchistosoma mansoniadenosine100 mM Hepes pH 7.4131.90.017397.58 × 10³pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T/N87T/Q289L, adenosine
MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP)variant S12T/N87T/Q289LSchistosoma mansoniphosphate12.790.43429pH 7.4PMID 27935959Open record: MTAP (5´-deoxy-5´-methylthioadenosine phosphorylase, SmMTAP) variant S12T/N87T/Q289L, phosphate