CatLogenzyme kinetics catalog

EC 2.4.3.1: beta-galactoside alpha-(2,6)-sialyltransferase

TransferasesOpen in Browse

CatLog read 33 records for EC 2.4.3.1 from 4 papers, for 4 organisms. Names in these papers: ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1), α-2,6-sialyltransferase, ST6Gal-I, Cps2N.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 30 records for EC 2.4.3.1 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.4.3.1 in Browse.

Papers

PaperOrganismsRecords
Enzymatic basis for N-glycan sialylation: structure of rat α2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylationRattus norvegicus (rat)18
Glycosyltransferase activity can be selectively modulated by chemical modifications of acceptor substratesRattus norvegicus11
Selective Engineering of Linkage-Specific α2,6-N-Linked Sialoproteins Using Sydnone-Modified Sialic Acid Bioorthogonal ReportersHomo sapiens3
Multi-Enzymatic Cascade Synthesis of Oligosaccharide Haptens from Streptococcus suis Serotype 2 and 1/2 Capsular Polysaccharides and Antigenicity EvaluationStreptococcus suis1

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
Cps2NStreptococcus suisCMP-N-acetylneuraminic acid1.970.533.72PMID 42063853Open
ST6Gal-IHomo sapiensCMP-Neu5Ac0.180.1191.53PMID 30706985Open
ST6Gal-IHomo sapiensCMP-Neu9Az0.30.3850.78PMID 30706985Open
ST6Gal-IHomo sapiensCMP-Neu9NSydCl0.170.0861.93PMID 30706985Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)Rattus norvegicus (rat)CMP-N-acetylneuraminic acidexpressed in HEK293-F cells; Ni-NTA purified0.5930.0926.45pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)Rattus norvegicus (rat)CMP-N-acetylneuraminic acidtags removed by TEV protease and N-glycans trimmed by EndoF10.490.0935.27pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)Rattus norvegicus (rat)N-acetyllactosamineexpressed in HEK293-F cells; Ni-NTA purified0.6721.80.373pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)Rattus norvegicus (rat)N-acetyllactosaminetags removed by TEV protease and N-glycans trimmed by EndoF10.351.40.25pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant D271ARattus norvegicus (rat)CMP-N-acetylneuraminic acid0.0480.3650.13pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant D271ARattus norvegicus (rat)N-acetyllactosamine0.0926.50.013pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant F208ARattus norvegicus (rat)CMP-N-acetylneuraminic acid0.1880.40.47pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant F208ARattus norvegicus (rat)N-acetyllactosamine0.4310.438pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant K355ARattus norvegicus (rat)CMP-N-acetylneuraminic acid0.6930.0957.3pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant K355ARattus norvegicus (rat)N-acetyllactosamine0.3931.10.358pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant Q232ARattus norvegicus (rat)CMP-N-acetylneuraminic acid0.1030.1330.78pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant Q232ARattus norvegicus (rat)N-acetyllactosamine0.1352.60.052pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant Q354ARattus norvegicus (rat)CMP-N-acetylneuraminic acid0.4170.14.2pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant Q354ARattus norvegicus (rat)N-acetyllactosamine0.6431.80.357pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant Y119FRattus norvegicus (rat)CMP-N-acetylneuraminic acid0.390.0785pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant Y119FRattus norvegicus (rat)N-acetyllactosamine0.3131.80.173pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant Y272ARattus norvegicus (rat)CMP-N-acetylneuraminic acid0.050.220.23pH 6.5, 37 °CPMID 24155237Open
ST6GAL1 (beta-galactoside alpha2,6-sialyltransferase 1)variant Y272ARattus norvegicus (rat)N-acetyllactosamine0.0733.50.022pH 6.5, 37 °CPMID 24155237Open
α-2,6-sialyltransferaseRattus norvegicuscompound 10 (6-deoxy-6-formamido-2'-O-methyl LacNAc derivative)—3.1—PMID 15081009Open
α-2,6-sialyltransferaseRattus norvegicuscompound 13 (LacNAc C-6 N-methyl carboxamide, C(O)NHCH3)—2.4—PMID 15081009Open
α-2,6-sialyltransferaseRattus norvegicuscompound 2 (mono-O-methyl LacNAc derivative, methyl at C-6 or C-2')—4.1—PMID 15081009Open
α-2,6-sialyltransferaseRattus norvegicuscompound 3 (mono-O-methyl LacNAc derivative, methyl at C-6 or C-2')—4.3—PMID 15081009Open
α-2,6-sialyltransferaseRattus norvegicuscompound 4 (6,2'-di-O-methyl LacNAc derivative)—11.2—PMID 15081009Open
α-2,6-sialyltransferaseRattus norvegicuscompound 5 (6-O-methanesulfonyl LacNAc derivative)—0.7—PMID 15081009Open
α-2,6-sialyltransferaseRattus norvegicuscompound 6 (6-amino-6-deoxy LacNAc derivative)—5.8—PMID 15081009Open
α-2,6-sialyltransferaseRattus norvegicuscompound 7 (6-acetamido-6-deoxy LacNAc derivative, NHC(O)CH3 at C-6)—1.4—PMID 15081009Open
α-2,6-sialyltransferaseRattus norvegicuscompound 8 (6-deoxy-6-methanesulfonamido LacNAc derivative)—0.8—PMID 15081009Open
α-2,6-sialyltransferaseRattus norvegicuscompound 9 (6-deoxy-6-formamido LacNAc derivative)—1.1—PMID 15081009Open
α-2,6-sialyltransferaseRattus norvegicusN-acetyllactosamine—1.7—PMID 15081009Open