CatLogenzyme kinetics catalog

EC 2.5.1.15: dihydropteroate synthase

TransferasesOpen in Browse

CatLog read 27 records for EC 2.5.1.15 from 3 papers, for 4 organisms. Names in these papers: dihydropteroate synthase (DHPS), dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 66 records for EC 2.5.1.15 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.5.1.15 in Browse.

Papers

PaperOrganismsRecords
The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistancePlasmodium falciparum12
Examination of intrinsic sulfonamide resistance in Bacillus anthracis: a novel assay for dihydropteroate synthaseBacillus anthracis11
Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coliMycobacterium leprae, Mycobacterium tuberculosis4

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
dihydropteroate synthase (DHPS)Bacillus anthracis6-hydroxymethyl-7,8-dihydropterin diphosphate0.075——pH 7.5, 25 °CPMID 18342015Open
dihydropteroate synthase (DHPS)Bacillus anthracis6-hydroxymethyl-7,8-dihydropterin diphosphatecosubstrate pABA, fixed at 100 uM—0.0027—pH 7.5, 25 °CPMID 18342015Open
dihydropteroate synthase (DHPS)Bacillus anthracisDapson0.05785.8 × 10⁻⁵1003pH 7.5, 25 °CPMID 18342015Open
dihydropteroate synthase (DHPS)Bacillus anthracispara-aminobenzoic acid2.15 µg DHPS in 500 µL; DHP-PP fixed at 20 µM0.1090.002249pH 7.5, 25 °CPMID 18342015Open
dihydropteroate synthase (DHPS)Bacillus anthracispara-aminobenzoic acid1.08 µg DHPS in 0.25 mL—0.0026—pH 7.5, 25 °CPMID 18342015Open
dihydropteroate synthase (DHPS)Bacillus anthracissulfadiazine sodium salt0.12430.0028943pH 7.5, 25 °CPMID 18342015Open
dihydropteroate synthase (DHPS)Bacillus anthracisSulfamethizole0.0797 × 10⁻⁴110pH 7.5, 25 °CPMID 18342015Open
dihydropteroate synthase (DHPS)Bacillus anthracisSulfamethoxazole0.120.002744pH 7.5, 25 °CPMID 18342015Open
dihydropteroate synthase (DHPS)Bacillus anthracisSulfanilamide0.086 × 10⁻⁴130pH 7.5, 25 °CPMID 18342015Open
dihydropteroate synthase (DHPS)Bacillus anthracissulfathiazole sodium salt0.08873.3 × 10⁻⁴268pH 7.5, 25 °CPMID 18342015Open
dihydropteroate synthase (DHPS)Bacillus anthracisSulfisoxazole0.110.001573pH 7.5, 25 °CPMID 18342015Open
dihydropteroate synthase (DHPS)Mycobacterium leprae6-hydroxymethyl-7,8-dihydropterin pyrophosphate—0.0012—pH 8.3, 37 °CPMID 10542185Open
dihydropteroate synthase (DHPS)Mycobacterium lepraep-aminobenzoic acid0.1776 × 10⁻⁴290 calc.pH 8.3, 37 °CPMID 10542185Open
dihydropteroate synthase (DHPS)Mycobacterium tuberculosis6-hydroxymethyl-7,8-dihydropterin pyrophosphate—0.00103—pH 8.3, 37 °CPMID 10542185Open
dihydropteroate synthase (DHPS)Mycobacterium tuberculosisp-aminobenzoic acid0.583.7 × 10⁻⁴1.6 × 10³ calc.pH 8.3, 37 °CPMID 10542185Open
dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)Plasmodium falciparump-aminobenzoate0.01520.0014910.0 calc.pH 9, 37 °CPMID 31883412Open
dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant A437GPlasmodium falciparump-aminobenzoate0.023.3 × 10⁻⁴61 calc.pH 9, 37 °CPMID 31883412Open
dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant A437G/K540EPlasmodium falciparump-aminobenzoate0.00576.2 × 10⁻⁴9.1 calc.pH 9, 37 °CPMID 31883412Open
dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant A581GPlasmodium falciparump-aminobenzoate0.0290.004436.5 calc.pH 9, 37 °CPMID 31883412Open
dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant A613SPlasmodium falciparump-aminobenzoate0.0120.002235.4 calc.pH 9, 37 °CPMID 31883412Open
dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant A613TPlasmodium falciparump-aminobenzoate0.010.001019.9 calc.pH 9, 37 °CPMID 31883412Open
dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant K540EPlasmodium falciparump-aminobenzoate0.0110.001517.3 calc.pH 9, 37 °CPMID 31883412Open
dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant S436A/A437GPlasmodium falciparump-aminobenzoate0.00753.4 × 10⁻⁴22 calc.pH 9, 37 °CPMID 31883412Open
dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant S436F/A437G/A613SPlasmodium falciparump-aminobenzoate0.00774.6 × 10⁻⁴17 calc.pH 9, 37 °CPMID 31883412Open
dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant S436F/A437G/A613TPlasmodium falciparump-aminobenzoate0.01370.0013210.0 calc.pH 9, 37 °CPMID 31883412Open
dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant S436F/A613SPlasmodium falciparump-aminobenzoate0.0140.002176.5 calc.pH 9, 37 °CPMID 31883412Open
dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant S436F/A613TPlasmodium falciparump-aminobenzoate0.010.002454.1 calc.pH 9, 37 °CPMID 31883412Open