Values CatLog read from this paper
The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance
PMID 31883412doi:10.1111/febs.15196Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 12 records (24 values) from this paper: dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS) from Plasmodium falciparum.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 12 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS) | Plasmodium falciparum | p-aminobenzoate | 0.0152 | 0.00149 | 10.0 calc. | pH 9, 37 °C | Open record: dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS), p-aminobenzoate |
| dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant A437G | Plasmodium falciparum | p-aminobenzoate | 0.02 | 3.3 × 10⁻⁴ | 61 calc. | pH 9, 37 °C | Open record: dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS) variant A437G, p-aminobenzoate |
| dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant A437G/K540E | Plasmodium falciparum | p-aminobenzoate | 0.0057 | 6.2 × 10⁻⁴ | 9.1 calc. | pH 9, 37 °C | Open record: dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS) variant A437G/K540E, p-aminobenzoate |
| dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant A581G | Plasmodium falciparum | p-aminobenzoate | 0.029 | 0.00443 | 6.5 calc. | pH 9, 37 °C | Open record: dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS) variant A581G, p-aminobenzoate |
| dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant A613S | Plasmodium falciparum | p-aminobenzoate | 0.012 | 0.00223 | 5.4 calc. | pH 9, 37 °C | Open record: dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS) variant A613S, p-aminobenzoate |
| dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant A613T | Plasmodium falciparum | p-aminobenzoate | 0.01 | 0.00101 | 9.9 calc. | pH 9, 37 °C | Open record: dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS) variant A613T, p-aminobenzoate |
| dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant K540E | Plasmodium falciparum | p-aminobenzoate | 0.011 | 0.00151 | 7.3 calc. | pH 9, 37 °C | Open record: dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS) variant K540E, p-aminobenzoate |
| dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant S436A/A437G | Plasmodium falciparum | p-aminobenzoate | 0.0075 | 3.4 × 10⁻⁴ | 22 calc. | pH 9, 37 °C | Open record: dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS) variant S436A/A437G, p-aminobenzoate |
| dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant S436F/A437G/A613S | Plasmodium falciparum | p-aminobenzoate | 0.0077 | 4.6 × 10⁻⁴ | 17 calc. | pH 9, 37 °C | Open record: dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS) variant S436F/A437G/A613S, p-aminobenzoate |
| dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant S436F/A437G/A613T | Plasmodium falciparum | p-aminobenzoate | 0.0137 | 0.00132 | 10.0 calc. | pH 9, 37 °C | Open record: dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS) variant S436F/A437G/A613T, p-aminobenzoate |
| dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant S436F/A613S | Plasmodium falciparum | p-aminobenzoate | 0.014 | 0.00217 | 6.5 calc. | pH 9, 37 °C | Open record: dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS) variant S436F/A613S, p-aminobenzoate |
| dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS)variant S436F/A613T | Plasmodium falciparum | p-aminobenzoate | 0.01 | 0.00245 | 4.1 calc. | pH 9, 37 °C | Open record: dihydropteroate synthase (DHPS) domain of bifunctional HPPK-DHPS (PfHPPK-DHPS) variant S436F/A613T, p-aminobenzoate |