CatLogenzyme kinetics catalog

EC 2.7.1.145: deoxynucleoside kinase

TransferasesOpen in Browse

CatLog read 91 records for EC 2.7.1.145 from 7 papers, for 2 organisms. Names in these papers: deoxyribonucleoside kinase (Dm-dNK), Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase), deoxynucleoside kinase (Dm-dNK), deoxyribonucleoside kinase (DmdNK) and 1 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 27 records for EC 2.7.1.145 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.7.1.145 in Browse.

Papers

PaperOrganismsRecords
A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purinesDrosophila melanogaster35
Functional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase. Investigations of the putative catalytic glutamate-arginine pair and of residues responsible for…Drosophila melanogaster13
Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutantsDrosophila melanogaster11
Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinaseDrosophila melanogaster10
Identification of residues involved in the specificity and regulation of the highly efficient multisubstrate deoxyribonucleoside kinase from Drosophila melanogasterDrosophila melanogaster8
Biological phosphorylation of an Unnatural Base Pair (UBP) using a Drosophila melanogaster deoxynucleoside kinase (DmdNK) mutantDrosophila melanogaster8
Two thymidine kinases and one multisubstrate deoxyribonucleoside kinase salvage DNA precursors in Arabidopsis thalianaArabidopsis thaliana6

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
deoxynucleoside kinase (Dm-dNK)Drosophila melanogaster1-beta-D-arabinofuranosylcytosine—0.028970pH 8, 37 °CPMID 9461577Open
deoxynucleoside kinase (Dm-dNK)Drosophila melanogaster1-beta-D-arabinofuranosylcytosinekcat calculated from Vmax27——pH 8, 37 °CPMID 9461577Open
deoxynucleoside kinase (Dm-dNK)Drosophila melanogaster2'-deoxyadenosine—0.109160pH 8, 37 °CPMID 9461577Open
deoxynucleoside kinase (Dm-dNK)Drosophila melanogaster2'-deoxycytidine—0.0011.4 × 10⁴pH 8, 37 °CPMID 9461577Open
deoxynucleoside kinase (Dm-dNK)Drosophila melanogaster2'-deoxycytidinekcat calculated from Vmax15——pH 8, 37 °CPMID 9461577Open
deoxynucleoside kinase (Dm-dNK)Drosophila melanogaster2'-deoxyguanosine—0.65429pH 8, 37 °CPMID 9461577Open
deoxynucleoside kinase (Dm-dNK)Drosophila melanogasterATPcosubstrate dThd—0.0022—pH 8, 37 °CPMID 9461577Open
deoxynucleoside kinase (Dm-dNK)Drosophila melanogasterATPcosubstrate dCyd—0.0014—pH 8, 37 °CPMID 9461577Open
deoxynucleoside kinase (Dm-dNK)Drosophila melanogasterthymidine—9 × 10⁻⁴1.6 × 10⁴pH 8, 37 °CPMID 9461577Open
deoxynucleoside kinase (Dm-dNK)Drosophila melanogasterthymidinekcat calculated from Vmax15——pH 8, 37 °CPMID 9461577Open
deoxyribonucleoside kinase (AtdNK)Arabidopsis thaliana(E)-5-(2-bromovinyl)-2'-deoxyuridine0.1050.1130.93PMID 22897443Open
deoxyribonucleoside kinase (AtdNK)Arabidopsis thaliana2',2'-difluoro-2'-deoxycytidine0.770.1594.8PMID 22897443Open
deoxyribonucleoside kinase (AtdNK)Arabidopsis thaliana2'-deoxyadenosine0.470.014233PMID 22897443Open
deoxyribonucleoside kinase (AtdNK)Arabidopsis thaliana2'-deoxycytidine0.29——PMID 22897443Open
deoxyribonucleoside kinase (AtdNK)Arabidopsis thaliana2'-deoxyguanosine0.27——PMID 22897443Open
deoxyribonucleoside kinase (AtdNK)Arabidopsis thaliana2'-deoxyuridine0.230.5610.41PMID 22897443Open
deoxyribonucleoside kinase (Dm-dNK)Drosophila melanogaster1-beta-D-arabinofuranosylcytosine2.90.0243120PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)Drosophila melanogaster2',3'-dideoxycytidine4.21.1243.7PMID 10966789Open
deoxyribonucleoside kinase (Dm-dNK)Drosophila melanogaster2'-deoxyadenosine—0.225—pH 7.8, 37 °CPMID 10692477Open
deoxyribonucleoside kinase (Dm-dNK)Drosophila melanogaster2'-deoxyadenosinekcat per active site20.6—92pH 7.8, 37 °CPMID 10692477Open
deoxyribonucleoside kinase (Dm-dNK)Drosophila melanogaster2'-deoxycytidine—0.0023—pH 7.8, 37 °CPMID 10692477Open
deoxyribonucleoside kinase (Dm-dNK)Drosophila melanogaster2'-deoxycytidinekcat per active site16.5—7.2 × 10³pH 7.8, 37 °CPMID 10692477Open
deoxyribonucleoside kinase (Dm-dNK)Drosophila melanogaster2'-deoxyguanosine—0.665—pH 7.8, 37 °CPMID 10692477Open
deoxyribonucleoside kinase (Dm-dNK)Drosophila melanogaster2'-deoxyguanosinekcat per active site15.1—23pH 7.8, 37 °CPMID 10692477Open
deoxyribonucleoside kinase (Dm-dNK)Drosophila melanogaster3'-azido-2',3'-dideoxythymidine0.0360.00834.3PMID 10966789Open
deoxyribonucleoside kinase (Dm-dNK)Drosophila melanogasterthymidine—0.0012—pH 7.8, 37 °CPMID 10692477Open
deoxyribonucleoside kinase (Dm-dNK)Drosophila melanogasterthymidinekcat per active site14.2—1.2 × 10⁴pH 7.8, 37 °CPMID 10692477Open
deoxyribonucleoside kinase (Dm-dNK)variant A110DDrosophila melanogasterdeoxyadenosine0.0840.23870.352PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant A110DDrosophila melanogasterdeoxycytidine0.270.0912.967PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant A110DDrosophila melanogasterdeoxyguanosine0.0730.25690.284PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant A110DDrosophila melanogasterthymidine0.350.0645.468PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant M88RDrosophila melanogasterdeoxyadenosine1.882.0880.9PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant M88RDrosophila melanogasterdeoxycytidine7.51.0397.218PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant M88RDrosophila melanogasterdeoxyguanosine2.7——PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant M88RDrosophila melanogasterthymidine0.130.2370.548PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant M88R/A110DDrosophila melanogasterdeoxyadenosine6.90.359219PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant M88R/A110DDrosophila melanogasterdeoxycytidine3.50.5845.993PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant M88R/A110DDrosophila melanogasterdeoxyguanosine3.70.5496.74PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant M88R/A110DDrosophila melanogasterthymidine0.0342.4250.014PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant N45D/N64DDrosophila melanogaster2',3'-dideoxycytidine0.541.0930.49PMID 10966789Open
deoxyribonucleoside kinase (Dm-dNK)variant N45D/N64DDrosophila melanogaster3'-azido-2',3'-dideoxythymidine0.0520.00727.2PMID 10966789Open
deoxyribonucleoside kinase (Dm-dNK)variant N45D/N64DDrosophila melanogasterdeoxyadenosine0.8283.1660.26PMID 10966789Open
deoxyribonucleoside kinase (Dm-dNK)variant N45D/N64DDrosophila melanogasterdeoxycytidine4.040.096442PMID 10966789Open
deoxyribonucleoside kinase (Dm-dNK)variant N45D/N64DDrosophila melanogasterdeoxyguanosine0.0762.0040.038PMID 10966789Open
deoxyribonucleoside kinase (Dm-dNK)variant N45D/N64DDrosophila melanogasterthymidine1.220.024250PMID 10966789Open
deoxyribonucleoside kinase (Dm-dNK)variant V84ADrosophila melanogaster1-beta-D-arabinofuranosylcytosine2.530.033576PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84ADrosophila melanogasterdeoxyadenosine3.7——PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84ADrosophila melanogasterdeoxycytidine4.40.00251.76 × 10³PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84ADrosophila melanogasterdeoxyguanosine2.80.146619PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84ADrosophila melanogasterdideoxycytidine0.930.2923.185PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84ADrosophila melanogasterthymidine2.970.0113260PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84A/M88R/A110DDrosophila melanogasterdeoxyadenosine3.50.15323PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84A/M88R/A110DDrosophila melanogasterdeoxycytidine1.940.6272.615PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84A/M88R/A110DDrosophila melanogasterdeoxyguanosine1.73——PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84A/M88R/A110DDrosophila melanogasterthymidine0.111.5120.072PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84MDrosophila melanogasterdeoxyadenosine1.360.85151.597PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84MDrosophila melanogasterdeoxycytidine1.80.6742.67PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84MDrosophila melanogasterdeoxyguanosine0.221.9110.115PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84MDrosophila melanogasterthymidine0.0370.8290.084PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84SDrosophila melanogasterdeoxyadenosine1.10.14977.348PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84SDrosophila melanogasterdeoxycytidine0.830.012964PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84SDrosophila melanogasterdeoxyguanosine0.640.3751.706PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84SDrosophila melanogasterthymidine0.830.024733PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84S/M88R/A110DDrosophila melanogasterdeoxyadenosine3.20.3888.247PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84S/M88R/A110DDrosophila melanogasterdeoxycytidine1.622.1620.749PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84S/M88R/A110DDrosophila melanogasterdeoxyguanosine4.60.159229PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant V84S/M88R/A110DDrosophila melanogasterthymidine0.236.560.035PMID 11927571Open
deoxyribonucleoside kinase (Dm-dNK)variant ΔC10Drosophila melanogasterthymidine—0.0017—pH 7.8, 37 °CPMID 10692477Open
deoxyribonucleoside kinase (Dm-dNK)variant ΔC20Drosophila melanogasterthymidine—0.0017—pH 7.8, 37 °CPMID 10692477Open
deoxyribonucleoside kinase (Dm-dNK)variant ΔC30Drosophila melanogasterthymidine—0.0025—pH 7.8, 37 °CPMID 10692477Open
deoxyribonucleoside kinase (DmdNK)Drosophila melanogaster2-amino-8-(1'-beta-D-2'-deoxyribofuranosyl)-imidazo[1,2-a]-1,3,5-triazin-4(8H)-one0.8170.099pH 7.6, 37 °CPMID 28323896Open
deoxyribonucleoside kinase (DmdNK)Drosophila melanogaster6-amino-5-nitro-3-(1'-beta-D-2'-deoxyribofuranosyl)-2(1H)-pyridone0.00580.10170.058pH 7.6, 37 °CPMID 28323896Open
deoxyribonucleoside kinase (DmdNK)Drosophila melanogasterdeoxycytidine1.4330.0087165pH 7.6, 37 °CPMID 28323896Open
deoxyribonucleoside kinase (DmdNK)Drosophila melanogasterdeoxyguanosine1.2830.43073pH 7.6, 37 °CPMID 28323896Open
deoxyribonucleoside kinase (DmdNK)variant Q81EDrosophila melanogaster2-amino-8-(1'-beta-D-2'-deoxyribofuranosyl)-imidazo[1,2-a]-1,3,5-triazin-4(8H)-one1.3980.021765pH 7.6, 37 °CPMID 28323896Open
deoxyribonucleoside kinase (DmdNK)variant Q81EDrosophila melanogaster6-amino-5-nitro-3-(1'-beta-D-2'-deoxyribofuranosyl)-2(1H)-pyridone0.0676.8 × 10⁻⁴98pH 7.6, 37 °CPMID 28323896Open
deoxyribonucleoside kinase (DmdNK)variant Q81EDrosophila melanogasterdeoxycytidine2.10.0113180pH 7.6, 37 °CPMID 28323896Open
deoxyribonucleoside kinase (DmdNK)variant Q81EDrosophila melanogasterdeoxyguanosine0.7281.6130.45pH 7.6, 37 °CPMID 28323896Open
Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase)variant E52DDrosophila melanogasterdeoxycytidine7.1 × 10⁻⁴0.00370.19pH 7.5PMID 17302737Open
Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase)variant E52DDrosophila melanogasterdeoxythymidine7.2 × 10⁻⁴0.00380.19pH 7.5PMID 17302737Open
Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase)variant E52HDrosophila melanogasterdeoxycytidine0.00120.00580.2pH 7.5PMID 17302737Open
Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase)variant E52HDrosophila melanogasterdeoxythymidine0.0120.00373.2pH 7.5PMID 17302737Open
Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase)variant Q81NDrosophila melanogasterdeoxycytidine6.60.20532pH 7.5PMID 17302737Open
Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase)variant Q81NDrosophila melanogasterdeoxythymidine5.40.23123pH 7.5PMID 17302737Open
Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase)variant R105HDrosophila melanogasterdeoxycytidine0.0550.1130.49pH 7.5PMID 17302737Open
Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase)variant R105HDrosophila melanogasterdeoxythymidine0.00670.00890.75pH 7.5PMID 17302737Open
Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase)variant Y70WDrosophila melanogaster(E)-bromvinyl-2'-deoxyuridine0.40.004975pH 7.5PMID 17302737Open
Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase)variant Y70WDrosophila melanogaster1-(beta-D-arabinofuranosyl)-cytosine2.11.4411.4pH 7.5PMID 17302737Open
Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase)variant Y70WDrosophila melanogaster1-(beta-D-arabinofuranosyl)-thymine10.3572.9pH 7.5PMID 17302737Open
Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase)variant Y70WDrosophila melanogasterdeoxycytidine6.8——pH 7.5PMID 17302737Open
Dm-dNK (Drosophila melanogaster deoxyribonucleoside kinase)variant Y70WDrosophila melanogasterdeoxythymidine2.3——pH 7.5PMID 17302737Open