CatLogenzyme kinetics catalog

EC 2.7.11.25: mitogen-activated protein kinase kinase kinase

TransferasesOpen in Browse

CatLog read 12 records for EC 2.7.11.25 from 1 paper, for 1 organism. Names in these papers: COT kinase (cancer osaka thyroid, MAP3K).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 8 records for EC 2.7.11.25 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.7.11.25 in Browse.

Papers

PaperOrganismsRecords
Purification and kinetic characterization of recombinant human mitogen-activated protein kinase kinase kinase COT and the complexes with its cellular partner NF-kappa B1 p105Homo sapiens12

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
COT kinase (cancer osaka thyroid, MAP3K)Homo sapiensadenosine 5'-triphosphate5 mM MnCl2 (5 mM Mn2+)—0.02—pH 7.5PMID 16087150Open
COT kinase (cancer osaka thyroid, MAP3K)Homo sapiensadenosine 5'-triphosphate10 mM MgCl2 (10 mM Mg2+)—0.39—pH 7.5PMID 16087150Open
COT kinase (cancer osaka thyroid, MAP3K)Homo sapiensadenosine 5'-triphosphate5 mM MnCl2 (5 mM Mn2+); baculovirus/Sf9—0.0301—pH 7.5PMID 16087150Open
COT kinase (cancer osaka thyroid, MAP3K)Homo sapiensadenosine 5'-triphosphate10 mM MgCl2 (10 mM Mg2+); baculovirus/Sf9—0.31—pH 7.5PMID 16087150Open
COT kinase (cancer osaka thyroid, MAP3K)Homo sapiensadenosine 5'-triphosphate5 mM MnCl2 (5 mM Mn2+); baculovirus/Sf9—0.0297—pH 7.5PMID 16087150Open
COT kinase (cancer osaka thyroid, MAP3K)Homo sapiensadenosine 5'-triphosphate10 mM MgCl2 (10 mM Mg2+); baculovirus/Sf9—0.394—pH 7.5PMID 16087150Open
COT kinase (cancer osaka thyroid, MAP3K)Homo sapiensMAP/Erk kinase (unactive GST-MEK protein, MAP2K)5 mM MnCl2 (5 mM Mn2+)0.2571.9 × 10⁻⁴1.35 × 10³pH 7.5PMID 16087150Open
COT kinase (cancer osaka thyroid, MAP3K)Homo sapiensMAP/Erk kinase (unactive GST-MEK protein, MAP2K)10 mM MgCl2 (10 mM Mg2+)0.2453.6 × 10⁻⁴680pH 7.5PMID 16087150Open
COT kinase (cancer osaka thyroid, MAP3K)Homo sapiensMAP/Erk kinase (unactive GST-MEK protein, MAP2K)5 mM MnCl2 (5 mM Mn2+); baculovirus/Sf90.03253 × 10⁻⁴108pH 7.5PMID 16087150Open
COT kinase (cancer osaka thyroid, MAP3K)Homo sapiensMAP/Erk kinase (unactive GST-MEK protein, MAP2K)10 mM MgCl2 (10 mM Mg2+); baculovirus/Sf90.03283 × 10⁻⁴110pH 7.5PMID 16087150Open
COT kinase (cancer osaka thyroid, MAP3K)Homo sapiensMAP/Erk kinase (unactive GST-MEK protein, MAP2K)5 mM MnCl2 (5 mM Mn2+); baculovirus/Sf90.00551.6 × 10⁻⁴35pH 7.5PMID 16087150Open
COT kinase (cancer osaka thyroid, MAP3K)Homo sapiensMAP/Erk kinase (unactive GST-MEK protein, MAP2K)10 mM MgCl2 (10 mM Mg2+); baculovirus/Sf90.0053.1 × 10⁻⁴17pH 7.5PMID 16087150Open