EC 2.7.4.14: UMP/CMP kinase
TransferasesOpen in Browse
CatLog read 64 records for EC 2.7.4.14 from 4 papers, for 4 organisms. Names in these papers: CMP kinase, pyrimidine nucleoside monophosphate kinase, UMP-CMP kinase, UMP/CMP kinase 1 (UMP/CMPK1).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 14 records for EC 2.7.4.14 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.7.4.14 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase | Escherichia coli | 20 |
| Pyrimidine nucleoside monophosphate kinase from rat liver and rat Novikoff ascites hepatoma (EC 2.7.4.14) | Rattus norvegicus | 18 |
| Reaction of human UMP-CMP kinase with natural and analog substrates | Dictyostelium discoideum, Homo sapiens | 15 |
| Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1 | Homo sapiens | 11 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| CMP kinasevariant D132A | Escherichia coli | 2'-deoxycytidine 5'-monophosphate | 0.73 | 1.8 | 0.4 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant D132A, 2'-deoxycytidine 5'-monophosphate |
| CMP kinasevariant D132A | Escherichia coli | cytidine 5'-monophosphate | 4.1 | 2.9 | 1.41 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant D132A, cytidine 5'-monophosphate |
| CMP kinasevariant D132A | Escherichia coli | uridine 5'-monophosphate | 9.9 | 7.9 | 1.25 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant D132A, uridine 5'-monophosphate |
| CMP kinasevariant D132H | Escherichia coli | 2'-deoxycytidine 5'-monophosphate | 0.06 | 0.055 | 1.1 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant D132H, 2'-deoxycytidine 5'-monophosphate |
| CMP kinasevariant D132H | Escherichia coli | cytidine 5'-monophosphate | 0.069 | 1.3 | 0.053 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant D132H, cytidine 5'-monophosphate |
| CMP kinasevariant D132H | Escherichia coli | uridine 5'-monophosphate | 0.013 | 3.9 | 0.0033 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant D132H, uridine 5'-monophosphate |
| CMP kinasevariant D132N | Escherichia coli | 2'-deoxycytidine 5'-monophosphate | 0.15 | 0.08 | 1.88 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant D132N, 2'-deoxycytidine 5'-monophosphate |
| CMP kinasevariant D132N | Escherichia coli | cytidine 5'-monophosphate | 1.4 | 2.6 | 0.54 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant D132N, cytidine 5'-monophosphate |
| CMP kinasevariant D132N | Escherichia coli | uridine 5'-monophosphate | 0.45 | 5.4 | 0.083 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant D132N, uridine 5'-monophosphate |
| CMP kinasevariant D132S | Escherichia coli | 2'-deoxycytidine 5'-monophosphate | 21.1 | 0.09 | 230 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant D132S, 2'-deoxycytidine 5'-monophosphate |
| CMP kinasevariant D132S | Escherichia coli | cytidine 5'-monophosphate | 22.4 | 0.038 | 589 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant D132S, cytidine 5'-monophosphate |
| CMP kinasevariant D132S | Escherichia coli | uridine 5'-monophosphate | 8.3 | 8 | 1.04 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant D132S, uridine 5'-monophosphate |
| CMP kinasevariant R110M | Escherichia coli | 2'-deoxycytidine 5'-monophosphate | 0.05 | 7.3 | 0.0068 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant R110M, 2'-deoxycytidine 5'-monophosphate |
| CMP kinasevariant R110M | Escherichia coli | cytidine 5'-monophosphate | 0.23 | 20.2 | 0.0114 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant R110M, cytidine 5'-monophosphate |
| CMP kinasevariant R110M | Escherichia coli | uridine 5'-monophosphate | 0.054 | 11.3 | 0.0048 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant R110M, uridine 5'-monophosphate |
| CMP kinasevariant R188M | Escherichia coli | 2'-deoxycytidine 5'-monophosphate | 0.04 | 0.77 | 0.052 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant R188M, 2'-deoxycytidine 5'-monophosphate |
| CMP kinasevariant R188M | Escherichia coli | cytidine 5'-monophosphate | 0.12 | 1 | 0.12 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant R188M, cytidine 5'-monophosphate |
| CMP kinasevariant S36A | Escherichia coli | 2'-deoxycytidine 5'-monophosphate | 14.5 | 3.5 | 4.1 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant S36A, 2'-deoxycytidine 5'-monophosphate |
| CMP kinasevariant S36A | Escherichia coli | cytidine 5'-monophosphate | 63 | 2.5 | 25.2 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant S36A, cytidine 5'-monophosphate |
| CMP kinasevariant S36A | Escherichia coli | uridine 5'-monophosphate | 0.57 | 1.9 | 0.3 | pH 7.4, 30 °C | PMID 17542990 | Open record: CMP kinase variant S36A, uridine 5'-monophosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | adenosine triphosphateCMP 0.13 mM fixed; cosubstrate CMP | — | 0.32 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, adenosine triphosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | adenosine triphosphatedCMP 1.17 mM fixed; cosubstrate dCMP | — | 0.68 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, adenosine triphosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | adenosine triphosphateUMP 0.58 mM fixed; cosubstrate UMP | — | 0.067 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, adenosine triphosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | adenosine triphosphate | — | 0.134 | — | 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, adenosine triphosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | cytidine monophosphateATP 1.47 mM fixed; CMP varied 0.004-0.048 mM | — | 0.03 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, cytidine monophosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | cytidine monophosphatedATP 1.47 mM fixed; CMP varied 0.004-0.048 mM | — | 0.027 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, cytidine monophosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | cytidine monophosphatedCTP 5.60 mM fixed; CMP varied 0.012-0.598 mM | — | 0.98 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, cytidine monophosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | cytidine monophosphate | — | 0.0053 | — | 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, cytidine monophosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | deoxyadenosine triphosphateCMP 0.13 mM fixed; cosubstrate CMP | — | 0.074 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, deoxyadenosine triphosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | deoxyadenosine triphosphatedCMP 1.17 mM fixed; cosubstrate dCMP | — | 0.61 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, deoxyadenosine triphosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | deoxyadenosine triphosphateUMP 0.58 mM fixed; cosubstrate UMP | — | 0.42 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, deoxyadenosine triphosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | deoxycytidine monophosphateATP 1.47 mM fixed; cosubstrate ATP | — | 2.77 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, deoxycytidine monophosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | deoxycytidine monophosphatedATP 1.47 mM fixed; cosubstrate dATP | — | 1.1 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, deoxycytidine monophosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | deoxycytidine monophosphate | — | 0.715 | — | 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, deoxycytidine monophosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | deoxycytidine triphosphate | — | 0.82 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, deoxycytidine triphosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | uridine monophosphateATP 1.47 mM fixed; cosubstrate ATP | — | 0.04 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, uridine monophosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | uridine monophosphatedATP 1.47 mM fixed; cosubstrate dATP | — | 0.053 | — | pH 7.5, 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, uridine monophosphate |
| pyrimidine nucleoside monophosphate kinase | Rattus norvegicus | uridine monophosphate | — | 0.043 | — | 37 °C | PMID 211381 | Open record: pyrimidine nucleoside monophosphate kinase, uridine monophosphate |
| UMP-CMP kinase | Dictyostelium discoideum | 2'-deoxycytidine 5'-monophosphate | 22 | 2 | 11 | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, 2'-deoxycytidine 5'-monophosphate |
| UMP-CMP kinase | Dictyostelium discoideum | beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate | 10 | 2 | 5 | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate |
| UMP-CMP kinase | Dictyostelium discoideum | cytidine 5'-monophosphate | 410 | 0.2 | 2 × 10³ | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, cytidine 5'-monophosphate |
| UMP-CMP kinase | Dictyostelium discoideum | uridine 5'-monophosphate | 217 | 0.2 | 1.1 × 10³ | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, uridine 5'-monophosphate |
| UMP-CMP kinase | Homo sapiens | 2'-deoxycytidine 5'-monophosphate | 73 | 0.9 | 80 | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, 2'-deoxycytidine 5'-monophosphate |
| UMP-CMP kinase | Homo sapiens | 2'-deoxycytidine 5'-monophosphateN-terminal GST fusion (umpk-pGEX5X) | 30 | 1.1 | 30 | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, 2'-deoxycytidine 5'-monophosphate |
| UMP-CMP kinase | Homo sapiens | adenosine 5'-monophosphate | — | — | 1 | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, adenosine 5'-monophosphate |
| UMP-CMP kinase | Homo sapiens | beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate | 36 | 0.15 | 280 | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate |
| UMP-CMP kinase | Homo sapiens | beta-L-2',3'-dideoxy-3'-thiacytidine monophosphateN-terminal GST fusion (umpk-pGEX5X) | 14 | 0.3 | 46 | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate |
| UMP-CMP kinase | Homo sapiens | cytidine 5'-monophosphate | 130 | 0.02 | 6.5 × 10⁴ | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, cytidine 5'-monophosphate |
| UMP-CMP kinase | Homo sapiens | cytidine 5'-monophosphateN-terminal GST fusion (umpk-pGEX5X) | 72 | 0.07 | 1 × 10³ | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, cytidine 5'-monophosphate |
| UMP-CMP kinase | Homo sapiens | cytosine D-arabinofuranoside 5'-monophosphate | 150 | 0.26 | 580 | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, cytosine D-arabinofuranoside 5'-monophosphate |
| UMP-CMP kinase | Homo sapiens | cytosine D-arabinofuranoside 5'-monophosphateN-terminal GST fusion (umpk-pGEX5X) | 45 | 0.34 | 130 | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, cytosine D-arabinofuranoside 5'-monophosphate |
| UMP-CMP kinase | Homo sapiens | uridine 5'-monophosphate | 130 | 0.045 | 2.8 × 10⁴ | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, uridine 5'-monophosphate |
| UMP-CMP kinase | Homo sapiens | uridine 5'-monophosphateN-terminal GST fusion (umpk-pGEX5X) | 92 | 0.14 | 650 | pH 7.4, 37 °C | PMID 12694191 | Open record: UMP-CMP kinase, uridine 5'-monophosphate |
| UMP/CMP kinase 1 (UMP/CMPK1) | Homo sapiens | 2′-deoxycytidine-5′-monophosphate | 13.4 | 0.11 | 122 | PMID 26824416 | Open record: UMP/CMP kinase 1 (UMP/CMPK1), 2′-deoxycytidine-5′-monophosphate | |
| UMP/CMP kinase 1 (UMP/CMPK1) | Homo sapiens | 2′-deoxyuridine-5′-monophosphate | 5.8 | 1.034 | 5.61 | PMID 26824416 | Open record: UMP/CMP kinase 1 (UMP/CMPK1), 2′-deoxyuridine-5′-monophosphate | |
| UMP/CMP kinase 1 (UMP/CMPK1) | Homo sapiens | 5azaCDV | 0.47 | 2.08 | 0.226 | PMID 26824416 | Open record: UMP/CMP kinase 1 (UMP/CMPK1), 5azaCDV | |
| UMP/CMP kinase 1 (UMP/CMPK1) | Homo sapiens | arabinocytidine-5′-monophosphate | 130 | 0.315 | 410 | PMID 26824416 | Open record: UMP/CMP kinase 1 (UMP/CMPK1), arabinocytidine-5′-monophosphate | |
| UMP/CMP kinase 1 (UMP/CMPK1) | Homo sapiens | cidofovir | 0.09 | 2.3 | 0.04 | PMID 26824416 | Open record: UMP/CMP kinase 1 (UMP/CMPK1), cidofovir | |
| UMP/CMP kinase 1 (UMP/CMPK1) | Homo sapiens | cytidine-5′-monophosphate | 125 | 0.02 | 6.25 × 10³ | PMID 26824416 | Open record: UMP/CMP kinase 1 (UMP/CMPK1), cytidine-5′-monophosphate | |
| UMP/CMP kinase 1 (UMP/CMPK1) | Homo sapiens | uridine-5′-monophosphate | 188 | 0.1 | 1.88 × 10³ | PMID 26824416 | Open record: UMP/CMP kinase 1 (UMP/CMPK1), uridine-5′-monophosphate | |
| UMP/CMP kinase 1 (UMP/CMPK1)variant P64T | Homo sapiens | 2′-deoxycytidine-5′-monophosphate | 0.036 | 0.97 | 0.037 | PMID 26824416 | Open record: UMP/CMP kinase 1 (UMP/CMPK1) variant P64T, 2′-deoxycytidine-5′-monophosphate | |
| UMP/CMP kinase 1 (UMP/CMPK1)variant P64T | Homo sapiens | arabinocytidine-5′-monophosphate | 0.019 | 0.327 | 0.058 | PMID 26824416 | Open record: UMP/CMP kinase 1 (UMP/CMPK1) variant P64T, arabinocytidine-5′-monophosphate | |
| UMP/CMP kinase 1 (UMP/CMPK1)variant P64T | Homo sapiens | cytidine-5′-monophosphate | 0.31 | 0.123 | 2.52 | PMID 26824416 | Open record: UMP/CMP kinase 1 (UMP/CMPK1) variant P64T, cytidine-5′-monophosphate | |
| UMP/CMP kinase 1 (UMP/CMPK1)variant P64T | Homo sapiens | uridine-5′-monophosphate | 0.35 | 0.25 | 1.4 | PMID 26824416 | Open record: UMP/CMP kinase 1 (UMP/CMPK1) variant P64T, uridine-5′-monophosphate |