EC 2.7.7.43: N-acylneuraminate cytidylyltransferase
TransferasesOpen in Browse
CatLog read 56 records for EC 2.7.7.43 from 3 papers, for 4 organisms. Names in these papers: CMP-Neu5Ac synthetase (CNS), CMP-sialic acid synthetase (CSS), CMP-sialic acid synthetase (NmCSS), CMP-sialic acid synthetase (HdCSS) and 1 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 32 records for EC 2.7.7.43 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.7.7.43 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis | Neisseria meningitidis | 28 |
| A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases provides a tetramerization interface for the physiologically active enzyme | Mus musculus | 14 |
| Pasteurella multocida CMP-sialic acid synthetase and mutants of Neisseria meningitidis CMP-sialic acid synthetase with improved substrate promiscuity | Haemophilus ducreyi, Neisseria meningitidis and 1 more | 14 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| CMP-Neu5Ac synthetase (CNS) | Neisseria meningitidis | cytidine 5'-triphosphate | 10.17 | 0.017 | 600 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS), cytidine 5'-triphosphate |
| CMP-Neu5Ac synthetase (CNS) | Neisseria meningitidis | cytidine 5'-triphosphateapparent parameters | 9 | 0.034 | 270 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS), cytidine 5'-triphosphate |
| CMP-Neu5Ac synthetase (CNS) | Neisseria meningitidis | N-acetylneuraminic acid | — | 0.068 | 148 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS), N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS) | Neisseria meningitidis | N-acetylneuraminic acidapparent parameters | 9 | 0.13 | 68 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS), N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS) | Neisseria meningitidis | N-acetylneuraminic acidwith 0.2 mM dithiothreitol; apparent parameters | 9.3 | 0.19 | 49 calc. | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS), N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS)variant D211A | Neisseria meningitidis | cytidine 5'-triphosphate | 6.8 × 10⁻⁴ | 0.026 | 0.027 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant D211A, cytidine 5'-triphosphate |
| CMP-Neu5Ac synthetase (CNS)variant D211A | Neisseria meningitidis | N-acetylneuraminic acid | — | 0.066 | 0.0103 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant D211A, N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS)variant F192A | Neisseria meningitidis | cytidine 5'-triphosphate | 20 | 0.15 | 132 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant F192A, cytidine 5'-triphosphate |
| CMP-Neu5Ac synthetase (CNS)variant F192A | Neisseria meningitidis | N-acetylneuraminic acid | — | 0.38 | 52 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant F192A, N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS)variant F193A | Neisseria meningitidis | cytidine 5'-triphosphate | 5 | 0.052 | 97 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant F193A, cytidine 5'-triphosphate |
| CMP-Neu5Ac synthetase (CNS)variant F193A | Neisseria meningitidis | N-acetylneuraminic acid | — | 0.78 | 6.3 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant F193A, N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS)variant K142A | Neisseria meningitidis | cytidine 5'-triphosphate | 9.3 × 10⁻⁴ | 0.14 | 0.0063 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant K142A, cytidine 5'-triphosphate |
| CMP-Neu5Ac synthetase (CNS)variant K142A | Neisseria meningitidis | N-acetylneuraminic acid | — | — | 6 × 10⁻⁴ | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant K142A, N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS)variant N175A | Neisseria meningitidis | cytidine 5'-triphosphate | 25 | 0.27 | 90 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant N175A, cytidine 5'-triphosphate |
| CMP-Neu5Ac synthetase (CNS)variant N175A | Neisseria meningitidis | N-acetylneuraminic acid | — | 1.6 | 15.5 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant N175A, N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS)variant Q104A | Neisseria meningitidis | cytidine 5'-triphosphate | 2.17 | 0.031 | 72 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant Q104A, cytidine 5'-triphosphate |
| CMP-Neu5Ac synthetase (CNS)variant Q104A | Neisseria meningitidis | N-acetylneuraminic acid | — | 2.6 | 0.85 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant Q104A, N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS)variant Q104A | Neisseria meningitidis | N-acetylneuraminic acidapparent parameters | 1.83 | 4.7 | 0.4 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant Q104A, N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS)variant Q104E | Neisseria meningitidis | cytidine 5'-triphosphate | 7.7 × 10⁻⁴ | 0.2 | 0.0038 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant Q104E, cytidine 5'-triphosphate |
| CMP-Neu5Ac synthetase (CNS)variant Q104E | Neisseria meningitidis | N-acetylneuraminic acid | 4.5 × 10⁻⁴ | 0.31 | 0.00145 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant Q104E, N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS)variant Q104L | Neisseria meningitidis | cytidine 5'-triphosphate | 0.0028 | 0.15 | 0.018 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant Q104L, cytidine 5'-triphosphate |
| CMP-Neu5Ac synthetase (CNS)variant Q104L | Neisseria meningitidis | N-acetylneuraminic acid | — | — | 0.0048 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant Q104L, N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS)variant Q104N | Neisseria meningitidis | cytidine 5'-triphosphate | 0.0123 | 0.032 | 0.38 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant Q104N, cytidine 5'-triphosphate |
| CMP-Neu5Ac synthetase (CNS)variant Q104N | Neisseria meningitidis | N-acetylneuraminic acid | — | — | 0.0125 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant Q104N, N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS)variant R173A | Neisseria meningitidis | cytidine 5'-triphosphate | 7 | 0.048 | 143 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant R173A, cytidine 5'-triphosphate |
| CMP-Neu5Ac synthetase (CNS)variant R173A | Neisseria meningitidis | N-acetylneuraminic acid | — | 0.29 | 23 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant R173A, N-acetylneuraminic acid |
| CMP-Neu5Ac synthetase (CNS)variant Y179A | Neisseria meningitidis | cytidine 5'-triphosphate | 0.052 | 0.04 | 1.28 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant Y179A, cytidine 5'-triphosphate |
| CMP-Neu5Ac synthetase (CNS)variant Y179A | Neisseria meningitidis | N-acetylneuraminic acid | — | 0.11 | 0.47 | pH 7.5, 22 °C | PMID 20491913 | Open record: CMP-Neu5Ac synthetase (CNS) variant Y179A, N-acetylneuraminic acid |
| CMP-sialic acid synthetase (CSS) | Mus musculus | cytidine 5'-triphosphateresidues 39-432 (first 38 residues omitted) | 2.57 | 0.034 | 75 | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), cytidine 5'-triphosphate |
| CMP-sialic acid synthetase (CSS) | Mus musculus | cytidine 5'-triphosphateN-terminal domain residues 39-267 | 3.89 | — | — | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), cytidine 5'-triphosphate |
| CMP-sialic acid synthetase (CSS) | Mus musculus | cytidine 5'-triphosphateN-terminal domain residues 39-267 | — | 0.042 | — | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), cytidine 5'-triphosphate |
| CMP-sialic acid synthetase (CSS) | Mus musculus | cytidine 5'-triphosphateN-terminal domain residues 39-267 | — | — | 93 | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), cytidine 5'-triphosphate |
| CMP-sialic acid synthetase (CSS) | Mus musculus | cytidine 5'-triphosphateN-terminal domain residues 39-267 | 3.87 | — | — | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), cytidine 5'-triphosphate |
| CMP-sialic acid synthetase (CSS) | Mus musculus | cytidine 5'-triphosphateN-terminal domain residues 39-267 | — | 0.043 | — | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), cytidine 5'-triphosphate |
| CMP-sialic acid synthetase (CSS) | Mus musculus | cytidine 5'-triphosphateN-terminal domain residues 39-267 | — | — | 90 | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), cytidine 5'-triphosphate |
| CMP-sialic acid synthetase (CSS) | Mus musculus | N-acetylneuraminic acidresidues 39-432 (first 38 residues omitted) | 2.29 | 0.045 | 51 | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), N-acetylneuraminic acid |
| CMP-sialic acid synthetase (CSS) | Mus musculus | N-acetylneuraminic acidN-terminal domain residues 39-267 | 3.56 | — | — | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), N-acetylneuraminic acid |
| CMP-sialic acid synthetase (CSS) | Mus musculus | N-acetylneuraminic acidN-terminal domain residues 39-267 | — | 0.07 | — | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), N-acetylneuraminic acid |
| CMP-sialic acid synthetase (CSS) | Mus musculus | N-acetylneuraminic acidN-terminal domain residues 39-267 | — | — | 51 | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), N-acetylneuraminic acid |
| CMP-sialic acid synthetase (CSS) | Mus musculus | N-acetylneuraminic acidN-terminal domain residues 39-267 | 3.47 | — | — | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), N-acetylneuraminic acid |
| CMP-sialic acid synthetase (CSS) | Mus musculus | N-acetylneuraminic acidN-terminal domain residues 39-267 | — | 0.063 | — | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), N-acetylneuraminic acid |
| CMP-sialic acid synthetase (CSS) | Mus musculus | N-acetylneuraminic acidN-terminal domain residues 39-267 | — | — | 55 | pH 8, 22 °C | PMID 19666032 | Open record: CMP-sialic acid synthetase (CSS), N-acetylneuraminic acid |
| CMP-sialic acid synthetase (HdCSS) | Haemophilus ducreyi | cytidine 5'-triphosphate | 5.2 | 0.16 | 33 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (HdCSS), cytidine 5'-triphosphate |
| CMP-sialic acid synthetase (HdCSS) | Haemophilus ducreyi | N-acetylneuraminic acid | 4.8 | 0.18 | 27 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (HdCSS), N-acetylneuraminic acid |
| CMP-sialic acid synthetase (NmCSS) | Neisseria meningitidis | 8-O-methyl-N-acetylneuraminic acid | 2.9 | 5.3 | 0.55 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (NmCSS), 8-O-methyl-N-acetylneuraminic acid |
| CMP-sialic acid synthetase (NmCSS) | Neisseria meningitidis | cytidine 5'-triphosphate | 21 | 0.59 | 36 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (NmCSS), cytidine 5'-triphosphate |
| CMP-sialic acid synthetase (NmCSS) | Neisseria meningitidis | N-acetylneuraminic acid | 19 | 0.22 | 86 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (NmCSS), N-acetylneuraminic acid |
| CMP-sialic acid synthetase (NmCSS) | Neisseria meningitidis | N-glycolylneuraminic acid | 23 | 6.2 | 3.8 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (NmCSS), N-glycolylneuraminic acid |
| CMP-sialic acid synthetase (NmCSS) | Neisseria meningitidis | N-methylglycolylneuraminic acid | 3.2 | 2 | 1.6 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (NmCSS), N-methylglycolylneuraminic acid |
| CMP-sialic acid synthetase (NmCSS)variant S81R | Neisseria meningitidis | 8-O-methyl-N-acetylneuraminic acid | 1.9 | 1.5 | 1.3 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (NmCSS) variant S81R, 8-O-methyl-N-acetylneuraminic acid |
| CMP-sialic acid synthetase (NmCSS)variant S81R | Neisseria meningitidis | cytidine 5'-triphosphate | 8.8 | 0.22 | 40 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (NmCSS) variant S81R, cytidine 5'-triphosphate |
| CMP-sialic acid synthetase (NmCSS)variant S81R | Neisseria meningitidis | N-acetylneuraminic acid | 7.4 | 0.1 | 74 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (NmCSS) variant S81R, N-acetylneuraminic acid |
| CMP-sialic acid synthetase (NmCSS)variant S81R | Neisseria meningitidis | N-glycolylneuraminic acid | 23 | 4 | 5.9 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (NmCSS) variant S81R, N-glycolylneuraminic acid |
| CMP-sialic acid synthetase (NmCSS)variant S81R | Neisseria meningitidis | N-methylglycolylneuraminic acid | 12 | 7 | 1.7 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (NmCSS) variant S81R, N-methylglycolylneuraminic acid |
| CMP-sialic acid synthetase (PmCSS) | Pasteurella multocida | cytidine 5'-triphosphate | 4.6 | 0.24 | 19 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (PmCSS), cytidine 5'-triphosphate |
| CMP-sialic acid synthetase (PmCSS) | Pasteurella multocida | N-acetylneuraminic acid | 4.2 | 0.14 | 30 | pH 8.5, 37 °C | PMID 21968653 | Open record: CMP-sialic acid synthetase (PmCSS), N-acetylneuraminic acid |