CatLogenzyme kinetics catalog

EC 3.1.1.106: O-acetyl-ADP-ribose deacetylase

HydrolasesOpen in Browse

CatLog read 20 records for EC 3.1.1.106 from 1 paper, for 2 organisms. Names in these papers: MacroD1, YmdB.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 10 records for EC 3.1.1.106 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.1.1.106 in Browse.

Papers

PaperOrganismsRecords
Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylasesEscherichia coli, Homo sapiens20

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
MacroD1Homo sapiensO-acetyl-ADP-ribose50-200 mM Tris-HCl or 50 mM phosphate buffer; pH 7.30.20.3750.533pH 7.3, 23 °CPMID 21257746Open
MacroD1Homo sapiensO-acetyl-ADP-ribose50-200 mM Tris-HCl or 50 mM phosphate buffer; pH 7.30.198——pH 7.3, 23 °CPMID 21257746Open
MacroD1Homo sapiensO-acetyl-ADP-ribose50 mM Tris-HCl pH 7.3; 0.5 µM MacroD1; no ADPr (control)0.2020.37580.538 calc.pH 7.3, 23 °CPMID 21257746Open
MacroD1Homo sapiensO-acetyl-ADP-ribose50 mM Tris-HCl pH 7.3; 0.5 µM MacroD1; apparent Km0.2040.59090.345 calc.pH 7.3, 23 °CPMID 21257746Open
MacroD1Homo sapiensO-acetyl-ADP-ribose50 mM Tris-HCl pH 7.3; 0.5 µM MacroD1; apparent Km0.2010.98660.204 calc.pH 7.3, 23 °CPMID 21257746Open
MacroD1Homo sapiensO-acetyl-ADP-ribose50 mM Tris-HCl pH 7.3; 0.5 µM MacroD1; apparent Km0.1961.3500.145 calc.pH 7.3, 23 °CPMID 21257746Open
MacroD1variant C199AHomo sapiensO-acetyl-ADP-ribose0.179——pH 7.3, 23 °CPMID 21257746Open
MacroD1variant D160AHomo sapiensO-acetyl-ADP-ribose0.114——pH 7.3, 23 °CPMID 21257746Open
MacroD1variant D167AHomo sapiensO-acetyl-ADP-ribose0.136——pH 7.3, 23 °CPMID 21257746Open
MacroD1variant D184AHomo sapiensO-acetyl-ADP-ribose0.078——pH 7.3, 23 °CPMID 21257746Open
MacroD1variant H188AHomo sapiensO-acetyl-ADP-ribose0.114——pH 7.3, 23 °CPMID 21257746Open
MacroD1variant N171AHomo sapiensO-acetyl-ADP-ribose0.082——pH 7.3, 23 °CPMID 21257746Open
MacroD1variant N174AHomo sapiensO-acetyl-ADP-ribose0.113——pH 7.3, 23 °CPMID 21257746Open
MacroD1variant N174A/D184AHomo sapiensO-acetyl-ADP-ribose0.014——pH 7.3, 23 °CPMID 21257746Open
MacroD1variant S176AHomo sapiensO-acetyl-ADP-ribose0.195——pH 7.3, 23 °CPMID 21257746Open
MacroD1variant S268AHomo sapiensO-acetyl-ADP-ribose0.153——pH 7.3, 23 °CPMID 21257746Open
MacroD1variant T226AHomo sapiensO-acetyl-ADP-ribose0.204——pH 7.3, 23 °CPMID 21257746Open
MacroD1variant ΔN58aaHomo sapiensO-acetyl-ADP-ribose0.210.2730.77pH 7.3, 23 °CPMID 21257746Open
YmdBEscherichia coliO-acetyl-ADP-ribose0.480.271.78pH 7.3, 23 °CPMID 21257746Open
YmdBvariant G124EEscherichia coliO-acetyl-ADP-ribose0.005——pH 7.3, 23 °CPMID 21257746Open