CatLogenzyme kinetics catalog

EC 3.1.1.23: acylglycerol lipase

HydrolasesOpen in Browse

CatLog read 39 records for EC 3.1.1.23 from 5 papers, for 2 organisms. Names in these papers: monoglyceride lipase (MGL), 303-amino-acid isoform, hormone-sensitive lipase (HSL), monoacylglycerol lipase (hMGL), monoacylglycerol lipase (MGL) and 1 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 44 records for EC 3.1.1.23 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.1.1.23 in Browse.

Papers

PaperOrganismsRecords
Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolutionHomo sapiens15
Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterasesHomo sapiens9
Specific Inter-residue Interactions as Determinants of Human Monoacylglycerol Lipase Catalytic Competency: A ROLE FOR GLOBAL CONFORMATIONAL CHANGESHomo sapiens8
Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolaseRattus norvegicus4
Molecular characterization of human ABHD2 as TAG lipase and ester hydrolaseHomo sapiens3

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
ABHD2 (alpha/beta hydrolase domain-containing protein 2; TAG lipase and ester hydrolase)Homo sapiensp-nitrophenyl acetate—12.40.01123PMID 27247428Open
ABHD2 (alpha/beta hydrolase domain-containing protein 2; TAG lipase and ester hydrolase)Homo sapiensp-nitrophenyl butyrate—11.760.01633PMID 27247428Open
ABHD2 (alpha/beta hydrolase domain-containing protein 2; TAG lipase and ester hydrolase)Homo sapiensp-nitrophenyl palmitate—17.660.00372PMID 27247428Open
hormone-sensitive lipase (HSL)Homo sapiens4-nitrophenyl butanoate190——pH 7.5, 25 °CPMID 16325466Open
hormone-sensitive lipase (HSL)Homo sapiensethenyl acetate140——pH 7.5, 25 °CPMID 16325466Open
hormone-sensitive lipase (HSL)Homo sapiensethenyl butanoate210——pH 7.5, 25 °CPMID 16325466Open
hormone-sensitive lipase (HSL)Homo sapiensethenyl dodecanoate31——pH 7.5, 25 °CPMID 16325466Open
hormone-sensitive lipase (HSL)Homo sapiensethenyl propanoate105——pH 7.5, 25 °CPMID 16325466Open
hormone-sensitive lipase (HSL)Homo sapiensglycerol tributanoate18——pH 7.5, 25 °CPMID 16325466Open
hormone-sensitive lipase (HSL)Homo sapiensglycerol trioctanoate6——pH 7.5, 25 °CPMID 16325466Open
hormone-sensitive lipase (HSL)Homo sapiensglycerol tripropanoate7——pH 7.5, 25 °CPMID 16325466Open
hormone-sensitive lipase (HSL)Homo sapiensOlive oil6——pH 7.5, 25 °CPMID 16325466Open
monoacylglycerol lipase (hMGL)Homo sapiens2-arachidonoylglycerol—0.025—pH 7.4PMID 26555264Open
monoacylglycerol lipase (hMGL)variant L169S/L176S (sol-hMGL)Homo sapiens2-arachidonoylglycerol5.7 × 10⁵0.0222.6 × 10⁷ calc.pH 7.4PMID 26555264Open
monoacylglycerol lipase (hMGL)variant L169S/L176S/H103A (sol-hMGL-H103A)Homo sapiens2-arachidonoylglycerol1.4 × 10⁴0.1221.3 × 10⁶pH 7.4PMID 26555264Open
monoacylglycerol lipase (hMGL)variant L169S/L176S/H272A (sol-hMGL-H272A)Homo sapiens2-arachidonoylglycerol4.5 × 10⁴0.02222 × 10⁶pH 7.4PMID 26555264Open
monoacylglycerol lipase (hMGL)variant L169S/L176S/H272S (sol-hMGL-H272S)Homo sapiens2-arachidonoylglycerol1.3 × 10⁴0.03084.2 × 10⁵pH 7.4PMID 26555264Open
monoacylglycerol lipase (hMGL)variant L169S/L176S/H272Y (sol-hMGL-H272Y)Homo sapiens2-arachidonoylglycerol7 × 10⁴0.03622.2 × 10⁶pH 7.4PMID 26555264Open
monoacylglycerol lipase (hMGL)variant L169S/L176S/H49A (sol-hMGL-H49A)Homo sapiens2-arachidonoylglycerol1.6 × 10⁵0.03664.4pH 7.4PMID 26555264Open
monoacylglycerol lipase (hMGL)variant L169S/L176S/H54A (sol-hMGL-H54A)Homo sapiens2-arachidonoylglycerol110.012980pH 7.4PMID 26555264Open
monoacylglycerol lipase (MGL)Rattus norvegicus2-arachidonylglycerol0.350.0135pH 8, 37 °CPMID 17649977Open
monoacylglycerol lipase (MGL)Rattus norvegicusprostaglandin D2 glycerol ester0.0680.1330.52pH 8, 37 °CPMID 17649977Open
monoacylglycerol lipase (MGL)Rattus norvegicusprostaglandin E2 glycerol ester0.160.151.07pH 8, 37 °CPMID 17649977Open
monoacylglycerol lipase (MGL)Rattus norvegicusprostaglandin F2α glycerol ester0.1430.3110.45pH 8, 37 °CPMID 17649977Open
monoglyceride lipase (MGL), 303-amino-acid isoformHomo sapiens2-oxo-2H-chromen-7-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate——1.5pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformHomo sapiens4-methyl-2-oxo-2H-chromen-7-yl butanoate1.130.1627pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformvariant L167Q/L171QHomo sapiens4-methyl-2-oxo-2H-chromen-7-yl butanoate0.980.08411.8pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformvariant L167Q/L174QHomo sapiens4-methyl-2-oxo-2H-chromen-7-yl butanoate1.20.08413.8pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformvariant L169S/L176SHomo sapiens2-oxo-2H-chromen-7-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate——1.7pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformvariant L169S/L176SHomo sapiens4-methyl-2-oxo-2H-chromen-7-yl butanoate0.80.1365.8pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformvariant L169S/L176SHomo sapiens4-methyl-2-oxo-2H-chromen-7-yl butanoateN-terminally truncated at residue 90.450.0885.2pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformvariant L169S/L176SHomo sapiens4-methyl-2-oxo-2H-chromen-7-yl butanoateN-terminally and C-terminally truncated; residues 9-2970.430.1263.5pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformvariant L169S/L176S/K160AHomo sapiens4-methyl-2-oxo-2H-chromen-7-yl butanoate0.50.095.5pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformvariant L169S/L176S/K165AHomo sapiens4-methyl-2-oxo-2H-chromen-7-yl butanoate0.450.1373.3pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformvariant L169S/L176S/K226AHomo sapiens4-methyl-2-oxo-2H-chromen-7-yl butanoate0.630.115.8pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformvariant L169S/L176S/K36AHomo sapiens4-methyl-2-oxo-2H-chromen-7-yl butanoate0.850.1246.8pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformvariant L169S/L176S/K36A/K226AHomo sapiens4-methyl-2-oxo-2H-chromen-7-yl butanoate0.50.1234.2pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformvariant L171QHomo sapiens4-methyl-2-oxo-2H-chromen-7-yl butanoate0.850.1058pH 7, 37 °CPMID 21308848Open
monoglyceride lipase (MGL), 303-amino-acid isoformvariant L171Q/L174QHomo sapiens4-methyl-2-oxo-2H-chromen-7-yl butanoate0.780.0898.7pH 7, 37 °CPMID 21308848Open