EC 3.1.1.25: 1,4-lactonase

HydrolasesOpen in Browse

CatLog read 72 records for EC 3.1.1.25 from 7 papers, for 5 organisms. Names in these papers: zearalenone lactonase ZHD101, VmoLac (phosphotriesterase-like lactonase), phospho-furanose lactonase Ms0025 (MS53_0025), SacPox (phosphotriesterase-like lactonase) and 3 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 32 records for EC 3.1.1.25 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.1.1.25 in Browse.

Papers

Papers with records for EC 3.1.1.25
Paper	Organisms	Records
Computational design of enhanced detoxification activity of a zearalenone lactonase from Clonostachys rosea in acidic medium	Clonostachys rosea	17
Crystal structure of VmoLac, a tentative quorum quenching lactonase from the extremophilic crenarchaeon Vulcanisaeta moutnovskia	Vulcanisaeta moutnovskia	16
Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate	Mycoplasma synoviae	14
SacPox from the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius is a proficient lactonase	Sulfolobus acidocaldarius	11
Characterization of a phosphotriesterase-like lactonase from the hyperthermoacidophilic crenarchaeon Vulcanisaeta moutnovskia	Vulcanisaeta moutnovskia	6
High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I	—	5
Interplay between amino acid residues at positions 192 and 115 in modulating hydrolytic activities of human paraoxonase 1	Homo sapiens	3

Records

Records for EC 3.1.1.25 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
human paraoxonase 1 (h-PON1)	Homo sapiens	delta-valerolactone	29.8	1.5	19.8	pH 8.3, 25 °C	PMID 25107406	Open record: human paraoxonase 1 (h-PON1), delta-valerolactone
human paraoxonase 1 (h-PON1)variant H115W	Homo sapiens	delta-valerolactone	0.5	0.4	1.3	pH 8.3, 25 °C	PMID 25107406	Open record: human paraoxonase 1 (h-PON1) variant H115W, delta-valerolactone
human paraoxonase 1 (h-PON1)variant H115W/R192K	Homo sapiens	delta-valerolactone	0.9	0.5	1.9	pH 8.3, 25 °C	PMID 25107406	Open record: human paraoxonase 1 (h-PON1) variant H115W/R192K, delta-valerolactone
phospho-furanose lactonase Ms0025 (MS53_0025)	Mycoplasma synoviae	compound 12 (diacid sugar lactone)	2.9	1	2.9	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025), compound 12 (diacid sugar lactone)
phospho-furanose lactonase Ms0025 (MS53_0025)	Mycoplasma synoviae	compound 20 (diacid sugar lactone)	7.1	2.5	2.8	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025), compound 20 (diacid sugar lactone)
phospho-furanose lactonase Ms0025 (MS53_0025)	Mycoplasma synoviae	compound 22 (diacid sugar lactone)	5.6	1.7	3.3	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025), compound 22 (diacid sugar lactone)
phospho-furanose lactonase Ms0025 (MS53_0025)	Mycoplasma synoviae	D-xylono-1,4-lactone-5-phosphate	23.4	0.5	47	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025), D-xylono-1,4-lactone-5-phosphate
phospho-furanose lactonase Ms0025 (MS53_0025)	Mycoplasma synoviae	L-arabino-1,4-lactone-5-phosphate	6.7	0.3	22	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025), L-arabino-1,4-lactone-5-phosphate
phospho-furanose lactonase Ms0025 (MS53_0025)variant E34Q	Mycoplasma synoviae	compound 22 (diacid sugar lactone)	0.4	3.8	0.11	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025) variant E34Q, compound 22 (diacid sugar lactone)
phospho-furanose lactonase Ms0025 (MS53_0025)variant E34Q	Mycoplasma synoviae	D-xylono-1,4-lactone-5-phosphate	0.9	0.7	1.3	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025) variant E34Q, D-xylono-1,4-lactone-5-phosphate
phospho-furanose lactonase Ms0025 (MS53_0025)variant E34Q	Mycoplasma synoviae	L-arabino-1,4-lactone-5-phosphate	0.58	1.8	0.32	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025) variant E34Q, L-arabino-1,4-lactone-5-phosphate
phospho-furanose lactonase Ms0025 (MS53_0025)variant H100N	Mycoplasma synoviae	compound 22 (diacid sugar lactone)	0.23	1.5	0.15	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025) variant H100N, compound 22 (diacid sugar lactone)
phospho-furanose lactonase Ms0025 (MS53_0025)variant H100N	Mycoplasma synoviae	D-xylono-1,4-lactone-5-phosphate	6	2.7	0.22	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025) variant H100N, D-xylono-1,4-lactone-5-phosphate
phospho-furanose lactonase Ms0025 (MS53_0025)variant H100N	Mycoplasma synoviae	L-arabino-1,4-lactone-5-phosphate	0.64	0.83	0.77	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025) variant H100N, L-arabino-1,4-lactone-5-phosphate
phospho-furanose lactonase Ms0025 (MS53_0025)variant K29A	Mycoplasma synoviae	compound 22 (diacid sugar lactone)	0.11	2.1	0.052	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025) variant K29A, compound 22 (diacid sugar lactone)
phospho-furanose lactonase Ms0025 (MS53_0025)variant K29A	Mycoplasma synoviae	D-xylono-1,4-lactone-5-phosphate	1.1	1.4	0.79	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025) variant K29A, D-xylono-1,4-lactone-5-phosphate
phospho-furanose lactonase Ms0025 (MS53_0025)variant K29A	Mycoplasma synoviae	L-arabino-1,4-lactone-5-phosphate	0.42	0.75	0.56	pH 8.3	PMID 24955762	Open record: phospho-furanose lactonase Ms0025 (MS53_0025) variant K29A, L-arabino-1,4-lactone-5-phosphate
phosphotriesterase-like lactonase (VmutPLL)	Vulcanisaeta moutnovskia	(5R)-5-ethyloxolan-2-one	3.04	0.55	5.564	pH 8.3, 40 °C	PMID 24858677	Open record: phosphotriesterase-like lactonase (VmutPLL), (5R)-5-ethyloxolan-2-one
phosphotriesterase-like lactonase (VmutPLL)	Vulcanisaeta moutnovskia	(5R)-5-methyloxolan-2-one	6.23	4.56	1.327	pH 8.3, 40 °C	PMID 24858677	Open record: phosphotriesterase-like lactonase (VmutPLL), (5R)-5-methyloxolan-2-one
phosphotriesterase-like lactonase (VmutPLL)	Vulcanisaeta moutnovskia	(5S)-5-ethyloxolan-2-one	1.89	0.75	2.531	pH 8.3, 40 °C	PMID 24858677	Open record: phosphotriesterase-like lactonase (VmutPLL), (5S)-5-ethyloxolan-2-one
phosphotriesterase-like lactonase (VmutPLL)	Vulcanisaeta moutnovskia	(5S)-5-methyloxolan-2-one	2.68	1.95	1.38	pH 8.3, 40 °C	PMID 24858677	Open record: phosphotriesterase-like lactonase (VmutPLL), (5S)-5-methyloxolan-2-one
phosphotriesterase-like lactonase (VmutPLL)	Vulcanisaeta moutnovskia	oxolan-2-one	2.79	11.57	0.2417	pH 8.3, 40 °C	PMID 24858677	Open record: phosphotriesterase-like lactonase (VmutPLL), oxolan-2-one
phosphotriesterase-like lactonase (VmutPLL)	Vulcanisaeta moutnovskia	whiskey lactone	4.2	0.93	4.539	pH 8.3, 40 °C	PMID 24858677	Open record: phosphotriesterase-like lactonase (VmutPLL), whiskey lactone
SacPox (phosphotriesterase-like lactonase)	Sulfolobus acidocaldarius	delta-dodecalactone	3.34	0.185	18.1	pH 8.3, 25 °C	PMID 24894602	Open record: SacPox (phosphotriesterase-like lactonase), delta-dodecalactone
SacPox (phosphotriesterase-like lactonase)	Sulfolobus acidocaldarius	delta-nonalactone	4.55	0.348	13.1	pH 8.3, 25 °C	PMID 24894602	Open record: SacPox (phosphotriesterase-like lactonase), delta-nonalactone
SacPox (phosphotriesterase-like lactonase)	Sulfolobus acidocaldarius	delta-undecalactone	1.05	0.168	6.22	pH 8.3, 25 °C	PMID 24894602	Open record: SacPox (phosphotriesterase-like lactonase), delta-undecalactone
SacPox (phosphotriesterase-like lactonase)	Sulfolobus acidocaldarius	epsilon-caprolactone	15.04	1.031	14.6	pH 8.3, 25 °C	PMID 24894602	Open record: SacPox (phosphotriesterase-like lactonase), epsilon-caprolactone
SacPox (phosphotriesterase-like lactonase)	Sulfolobus acidocaldarius	gamma-dodecalactone	0.53	0.242	2.21	pH 8.3, 25 °C	PMID 24894602	Open record: SacPox (phosphotriesterase-like lactonase), gamma-dodecalactone
SacPox (phosphotriesterase-like lactonase)	Sulfolobus acidocaldarius	gamma-heptalactone	10.25	0.388	26.4	pH 8.3, 25 °C	PMID 24894602	Open record: SacPox (phosphotriesterase-like lactonase), gamma-heptalactone
SacPox (phosphotriesterase-like lactonase)	Sulfolobus acidocaldarius	gamma-nonalactone	2.64	0.109	24.4	pH 8.3, 25 °C	PMID 24894602	Open record: SacPox (phosphotriesterase-like lactonase), gamma-nonalactone
SacPox (phosphotriesterase-like lactonase)	Sulfolobus acidocaldarius	gamma-undecalactone	0.34	0.578	0.589	pH 8.3, 25 °C	PMID 24894602	Open record: SacPox (phosphotriesterase-like lactonase), gamma-undecalactone
SacPox (phosphotriesterase-like lactonase)	Sulfolobus acidocaldarius	N-(3-oxodecanoyl)-L-homoserine lactone	1.03	0.213	4.88	pH 8.3, 25 °C	PMID 24894602	Open record: SacPox (phosphotriesterase-like lactonase), N-(3-oxodecanoyl)-L-homoserine lactone
SacPox (phosphotriesterase-like lactonase)	Sulfolobus acidocaldarius	N-(3-oxooctanoyl)-L-homoserine lactone	0.89	0.836	1.07	pH 8.3, 25 °C	PMID 24894602	Open record: SacPox (phosphotriesterase-like lactonase), N-(3-oxooctanoyl)-L-homoserine lactone
SacPox (phosphotriesterase-like lactonase)	Sulfolobus acidocaldarius	N-octanoyl-DL-homoserine lactone	0.94	0.178	5.28	pH 8.3, 25 °C	PMID 24894602	Open record: SacPox (phosphotriesterase-like lactonase), N-octanoyl-DL-homoserine lactone
serum paraoxonase (PON1)variant rePON1-G3C9	—	γ-dodecanoic lactone0.1% tergitol (micellar detergent)	34	0.7	49	pH 8.3	PMID 16128586	Open record: serum paraoxonase (PON1) variant rePON1-G3C9, γ-dodecanoic lactone
serum paraoxonase (PON1)variant rePON1-G3C9	—	γ-dodecanoic lactoneapoA-I rHDL (10 microM; PC/FC/apoA-I particles)	101	0.3	390	pH 8.3	PMID 16128586	Open record: serum paraoxonase (PON1) variant rePON1-G3C9, γ-dodecanoic lactone
serum paraoxonase (PON1)variant rePON1-G3C9	—	δ-valerolactoneno amphiphile added (delipidated enzyme in activity buffer)	94	1	90	pH 8.3	PMID 16128586	Open record: serum paraoxonase (PON1) variant rePON1-G3C9, δ-valerolactone
serum paraoxonase (PON1)variant rePON1-G3C9	—	δ-valerolactoneenzyme incubated with 0.1% tergitol (micellar detergent)	156	0.9	170	pH 8.3	PMID 16128586	Open record: serum paraoxonase (PON1) variant rePON1-G3C9, δ-valerolactone
serum paraoxonase (PON1)variant rePON1-G3C9	—	δ-valerolactone	632	0.5	1.3 × 10³	pH 8.3	PMID 16128586	Open record: serum paraoxonase (PON1) variant rePON1-G3C9, δ-valerolactone
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	4-nitrophenyl acetate	0.0245	4.471	0.00548	pH 8, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), 4-nitrophenyl acetate
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	5-ethyloxolan-2-one (racemic gamma-hexalactone)	112.3	3.709	30.3	pH 8.3, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), 5-ethyloxolan-2-one (racemic gamma-hexalactone)
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	5-heptyloxolan-2-one	8.86	0.12	73.6	pH 8.3, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), 5-heptyloxolan-2-one
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	5-octyloxolan-2-one	0.16	—	—	pH 8.3, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), 5-octyloxolan-2-one
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	5-pentyloxolan-2-one	44.49	0.047	948	pH 8.3, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), 5-pentyloxolan-2-one
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	5-propyloxolan-2-one	27.25	0.872	31.2	pH 8.3, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), 5-propyloxolan-2-one
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	6-butyloxan-2-one	88.91	1.22	72.9	pH 8.3, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), 6-butyloxan-2-one
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	6-heptyloxan-2-one	28.08	—	—	pH 8.3, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), 6-heptyloxan-2-one
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	6-hexyloxan-2-one	60.78	0.105	580	pH 8.3, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), 6-hexyloxan-2-one
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	CMP-coumarin	0.13	2.05	0.0639	pH 8, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), CMP-coumarin
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	diethyl 4-nitrophenyl phosphate	0.00108	0.581	0.00186	pH 8, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), diethyl 4-nitrophenyl phosphate
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	dimethyl 4-nitrophenyl phosphate	—	—	0.00232	pH 8, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), dimethyl 4-nitrophenyl phosphate
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	N-(3-oxodecanoyl)-L-homoserine lactone	0.47	0.231	2.05	pH 8.3, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), N-(3-oxodecanoyl)-L-homoserine lactone
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	N-(3-oxooctanoyl)-L-homoserine lactone	0.35	0.186	1.88	pH 8.3, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), N-(3-oxooctanoyl)-L-homoserine lactone
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	N-octanoyl-DL-homoserine lactone	0.59	0.262	2.23	pH 8.3, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), N-octanoyl-DL-homoserine lactone
VmoLac (phosphotriesterase-like lactonase)	Vulcanisaeta moutnovskia	phenyl acetate	—	—	0.05815	pH 8, 25 °C	PMID 25670483	Open record: VmoLac (phosphotriesterase-like lactonase), phenyl acetate
zearalenone lactonase ZHD101	Clonostachys rosea	zearalenone	0.299	0.02825	10.57	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101, zearalenone
zearalenone lactonase ZHD101variant D133K	Clonostachys rosea	zearalenone	0.818	0.07841	10.43	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant D133K, zearalenone
zearalenone lactonase ZHD101variant D133K/D157K	Clonostachys rosea	zearalenone	0.132	0.03291	4.001	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant D133K/D157K, zearalenone
zearalenone lactonase ZHD101variant D133K/D157K/E171K	Clonostachys rosea	zearalenone	0.128	0.03377	3.789	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant D133K/D157K/E171K, zearalenone
zearalenone lactonase ZHD101variant D133K/E171K	Clonostachys rosea	zearalenone	0.235	0.04714	4.976	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant D133K/E171K, zearalenone
zearalenone lactonase ZHD101variant D157K	Clonostachys rosea	zearalenone	0.296	0.02083	14.19	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant D157K, zearalenone
zearalenone lactonase ZHD101variant D157K/E171K	Clonostachys rosea	zearalenone	0.265	0.08319	3.186	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant D157K/E171K, zearalenone
zearalenone lactonase ZHD101variant D57K	Clonostachys rosea	zearalenone	0.011	0.01117	1.026	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant D57K, zearalenone
zearalenone lactonase ZHD101variant E145K	Clonostachys rosea	zearalenone	0.308	0.03395	9.072	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant E145K, zearalenone
zearalenone lactonase ZHD101variant E171K	Clonostachys rosea	zearalenone	0.618	0.04532	13.64	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant E171K, zearalenone
zearalenone lactonase ZHD101variant E219K	Clonostachys rosea	zearalenone	0.207	0.02862	7.228	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant E219K, zearalenone
zearalenone lactonase ZHD101variant F222K	Clonostachys rosea	zearalenone	0.002	0.02897	0.057	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant F222K, zearalenone
zearalenone lactonase ZHD101variant L155K	Clonostachys rosea	zearalenone	0.167	0.02896	5.783	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant L155K, zearalenone
zearalenone lactonase ZHD101variant M154H	Clonostachys rosea	zearalenone	0.009	0.01169	0.7575	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant M154H, zearalenone
zearalenone lactonase ZHD101variant N152K	Clonostachys rosea	zearalenone	0.204	0.02309	8.829	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant N152K, zearalenone
zearalenone lactonase ZHD101variant V153H	Clonostachys rosea	zearalenone	0.064	0.0586	1.100	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant V153H, zearalenone
zearalenone lactonase ZHD101variant V158H	Clonostachys rosea	zearalenone	0.038	0.01704	2.216	pH 5.5, 37 °C	PMID 35527979	Open record: zearalenone lactonase ZHD101 variant V158H, zearalenone