CatLogenzyme kinetics catalog

EC 3.4.11.18: methionyl aminopeptidase

HydrolasesOpen in Browse

CatLog read 80 records for EC 3.4.11.18 from 9 papers, for 6 organisms. Names in these papers: methionine aminopeptidase 2 (MetAP2), methionine aminopeptidase 1 (MetAP1), methionyl aminopeptidase (EcMetAP-I), methionine aminopeptidase 1b (PfMetAP 1b) and 8 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 76 records for EC 3.4.11.18 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.11.18 in Browse.

Papers

PaperOrganismsRecords
Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidasesHomo sapiens35
Kinetic and spectroscopic characterization of the H178A methionyl aminopeptidase from Escherichia coliEscherichia coli8
Two methionine aminopeptidases from Acinetobacter baumannii are functional enzymesAcinetobacter baumannii8
N-Terminal methionine processing by the zinc-activated Plasmodium falciparum methionine aminopeptidase 1bPlasmodium falciparum6
Structural and functional highlights of methionine aminopeptidase 2 from Leishmania donovaniLeishmania donovani6
Mutations at the S1 sites of methionine aminopeptidases from Escherichia coli and Homo sapiens reveal the residues critical for substrate specificityEscherichia coli5
Analyzing the catalytic role of Asp97 in the methionine aminopeptidase from Escherichia coliEscherichia coli4
Expression and characterization of two functional methionine aminopeptidases from Mycobacterium tuberculosis H37RvMycobacterium tuberculosis4
The unique functional role of the C-HS hydrogen bond in the substrate specificity and enzyme catalysis of type 1 methionine aminopeptidaseMycobacterium tuberculosis4

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Ala-Arg-Ile-Glu-Ile-Tyr-NH2——6.6pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Ala-Glu-Ile-Glu-Ile-Tyr-NH2——1.7pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Ala-Glu-Trp-Glu-Ile-Tyr-NH2——5.3pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Ala-Gly-Ala-Ile-His-Tyr-NH2——10pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Ala-His-Ala-Ile-His-Tyr-NH2——41pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Ala-His-Ile-Glu-Ile-Tyr-NH2——3.58pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Ala-Pro-Ile-Glu-Ile-Tyr-NH2——1.3pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Ala-Trp-Ile-Glu-Ile-Tyr-NH2——9.6pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Gly-Glu-Ile-Glu-Ile-Tyr-NH2——0.18pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Pro-Glu-Ile-Glu-Ile-Tyr-NH2——0.16pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Thr-Glu-Ile-Glu-Ile-Tyr-NH2——0.029pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Val-Ala-Ala-Ala-Ala-Tyr-NH2——0.13pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Val-Asn-Pro-Thr-Val-Tyr-NH2——0.013pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Val-Gly-Val-Lys-Pro-Tyr-NH2——0.028pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Val-His-Gln-Val-Leu-Tyr-NH2——0.064pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Val-Leu-Ser-Pro-Ala-Tyr-NH2——0.015pH 7.4PMID 20521764Open
methionine aminopeptidase 1 (MetAP1)Homo sapiensMet-Val-Lys-Ile-Glu-Ile-Tyr-NH2——0.007pH 7.4PMID 20521764Open
methionine aminopeptidase 1b (PfMetAP 1b)Plasmodium falciparumMet-Gly-Met-Met100 μM Co2+ as activating9.1331.0628.6pH 7.5, 37 °CPMID 27023914Open
methionine aminopeptidase 1b (PfMetAP 1b)Plasmodium falciparumMet-Gly-Met-Met10 μM Co2+ as activating9.7181.1428.5pH 7.5, 37 °CPMID 27023914Open
methionine aminopeptidase 1b (PfMetAP 1b)Plasmodium falciparumMet-Gly-Met-Met1 μM Co2+ as activating16.751.7599.52pH 7.5, 37 °CPMID 27023914Open
methionine aminopeptidase 1b (PfMetAP 1b)Plasmodium falciparumMet-Gly-Met-Met100 μM Zn2+ as activating6.0721.6623.65pH 7.5, 37 °CPMID 27023914Open
methionine aminopeptidase 1b (PfMetAP 1b)Plasmodium falciparumMet-Gly-Met-Met10 μM Zn2+ as activating7.3751.1186.6pH 7.5, 37 °CPMID 27023914Open
methionine aminopeptidase 1b (PfMetAP 1b)Plasmodium falciparumMet-Gly-Met-Met1 μM Zn2+ as activating9.2080.845110.9pH 7.5, 37 °CPMID 27023914Open
methionine aminopeptidase 2 (LdMAP2)Leishmania donovaniL-alanine-4-methyl-coumaryl-7-amideCoCl22.1350.154113.8pH 7.5, 37 °CPMID 29680505Open
methionine aminopeptidase 2 (LdMAP2)Leishmania donovaniL-alanine-4-methyl-coumaryl-7-amideMgCl21.820.179210pH 7.5, 37 °CPMID 29680505Open
methionine aminopeptidase 2 (LdMAP2)Leishmania donovaniL-alanine-4-methyl-coumaryl-7-amideMnCl21.6650.16699.8pH 7.5, 37 °CPMID 29680505Open
methionine aminopeptidase 2 (LdMAP2)Leishmania donovaniL-alanine-4-methyl-coumaryl-7-amideCaCl21.4980.124712pH 7.5, 37 °CPMID 29680505Open
methionine aminopeptidase 2 (LdMAP2)Leishmania donovaniL-alanine-4-methyl-coumaryl-7-amideNiCl21.4730.28445.2pH 7.5, 37 °CPMID 29680505Open
methionine aminopeptidase 2 (LdMAP2)Leishmania donovaniL-alanine-4-methyl-coumaryl-7-amideCuCl20.430.17192.5pH 7.5, 37 °CPMID 29680505Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Ala-Arg-Ile-Glu-Ile-Tyr-NH2——23.3pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Ala-Glu-Ile-Glu-Ile-Tyr-NH2——1.04pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Ala-Glu-Trp-Glu-Ile-Tyr-NH2——2.16pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Ala-Gly-Ala-Ile-His-Tyr-NH2——37pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Ala-His-Ala-Ile-His-Tyr-NH2——36pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Ala-His-Ile-Glu-Ile-Tyr-NH2——5pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Ala-Pro-Ile-Glu-Ile-Tyr-NH2——0.54pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Ala-Trp-Ile-Glu-Ile-Tyr-NH2——4.9pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Gly-Glu-Ile-Glu-Ile-Tyr-NH2——0.66pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Pro-Glu-Ile-Glu-Ile-Tyr-NH2——0.14pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Thr-Glu-Ile-Glu-Ile-Tyr-NH2——0.46pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Val-Ala-Ala-Ala-Ala-Tyr-NH2——10pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Val-Asn-Pro-Thr-Val-Tyr-NH2——2.6pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Val-Glu-Ile-Glu-Ile-Tyr-NH2——0.45pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Val-Gly-Val-Lys-Pro-Tyr-NH2——2.07pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Val-His-Gln-Val-Leu-Tyr-NH2——4pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Val-Leu-Ser-Pro-Ala-Tyr-NH2——2.6pH 7.4PMID 20521764Open
methionine aminopeptidase 2 (MetAP2)Homo sapiensMet-Val-Lys-Ile-Glu-Ile-Tyr-NH2——0.86pH 7.4PMID 20521764Open
methionine aminopeptidase AbMetAPxAcinetobacter baumanniimethionyl-7-amino-4-methylcoumarinCo(II)-form: metal-free enzyme activated with 20 µM CoCl21.59 × 10⁻⁴0.1689.48 × 10⁻⁴PMID 21524572Open
methionine aminopeptidase AbMetAPxAcinetobacter baumanniimethionyl-7-amino-4-methylcoumarinMn(II)-form: metal-free enzyme activated with 20 µM MnCl25.08 × 10⁻⁵0.1543.3 × 10⁻⁴PMID 21524572Open
methionine aminopeptidase AbMetAPxAcinetobacter baumanniimethionyl-7-amino-4-methylcoumarinFe(II)-form: metal-free enzyme activated with 2.5 µM FeCl22.63 × 10⁻⁴0.1550.0017PMID 21524572Open
methionine aminopeptidase AbMetAPxAcinetobacter baumanniimethionyl-7-amino-4-methylcoumarinNi(II)-form: metal-free enzyme activated with 5 µM NiCl23.05 × 10⁻⁴0.1110.00275PMID 21524572Open
methionine aminopeptidase AbMetAPyAcinetobacter baumanniimethionyl-7-amino-4-methylcoumarinCo(II)-form: metal-free enzyme activated with 20 µM CoCl21.37 × 10⁻⁴0.130.00105PMID 21524572Open
methionine aminopeptidase AbMetAPyAcinetobacter baumanniimethionyl-7-amino-4-methylcoumarinMn(II)-form: metal-free enzyme activated with 20 µM MnCl25.5 × 10⁻⁵0.1154.79 × 10⁻⁴PMID 21524572Open
methionine aminopeptidase AbMetAPyAcinetobacter baumanniimethionyl-7-amino-4-methylcoumarinFe(II)-form: metal-free enzyme activated with 2.5 µM FeCl24.49 × 10⁻⁴0.1610.00278PMID 21524572Open
methionine aminopeptidase AbMetAPyAcinetobacter baumanniimethionyl-7-amino-4-methylcoumarinNi(II)-form: metal-free enzyme activated with 20 µM NiCl23.12 × 10⁻⁴0.1440.00217PMID 21524572Open
methionine aminopeptidase type 1c (MtMetAP1c)Mycobacterium tuberculosismethionine para-nitroanilide10.580.9810.79pH 7.5, 30 °CPMID 27225936Open
methionine aminopeptidase type 1c (MtMetAP1c)variant C105SMycobacterium tuberculosismethionine para-nitroanilide2.362.770.85pH 7.5, 30 °CPMID 27225936Open
methionine aminopeptidase type 1c (MtMetAP1c)variant C105TMycobacterium tuberculosismethionine para-nitroanilide6.32.472.54pH 7.5, 30 °CPMID 27225936Open
methionine aminopeptidase type 1c (MtMetAP1c)variant C105VMycobacterium tuberculosismethionine para-nitroanilide1.590.941.69pH 7.5, 30 °CPMID 27225936Open
methionine aminopeptidase type I (EcMetAP1)Escherichia coliMet-S-Gly-Phe22.50.3563.76pH 7PMID 14976199Open
methionine aminopeptidase type I (EcMetAP1)variant C70AEscherichia coliLeu-S-Gly-Phe20.80.3559.09pH 7PMID 14976199Open
methionine aminopeptidase type I (EcMetAP1)variant C70SEscherichia coliLeu-S-Gly-Phe4.040.1429.15pH 7PMID 14976199Open
methionine aminopeptidase type I (EcMetAP1)variant C70SEscherichia coliMet-S-Gly-Phe30.80.6845 calc.pH 7PMID 14976199Open
methionine aminopeptidase type I (EcMetAP1)variant C70SEscherichia coliPhe-S-Gly-Phe4.550.2419.31pH 7PMID 14976199Open
methionine aminopeptidase, type I (EcMetAP-I)Escherichia coliMet-Gly-Met-Met18.336pH 7.5, 30 °CPMID 19019076Open
methionine aminopeptidase, type I (EcMetAP-I)variant D97AEscherichia coliMet-Gly-Met-Met0.0031.10.003pH 7.5, 30 °CPMID 19019076Open
methionine aminopeptidase, type I (EcMetAP-I)variant D97EEscherichia coliMet-Gly-Met-Met0.0021.80.001pH 7.5, 30 °CPMID 19019076Open
methionine aminopeptidase, type I (EcMetAP-I)variant D97NEscherichia coliMet-Gly-Met-Met0.0010.60.002pH 7.5, 30 °CPMID 19019076Open
methionyl aminopeptidase (EcMetAP-I)Escherichia coliMet-Gly-Met-MetCo(II)-loaded enzyme; 12 µM CoCl2393.212.2pH 7.5PMID 12755633Open
methionyl aminopeptidase (EcMetAP-I)Escherichia coliMet-Gly-Met-MetFe(II)-loaded enzyme; 12 µM Fe(SO4)28214pH 7.5PMID 12755633Open
methionyl aminopeptidase (EcMetAP-I)Escherichia coliMet-Pro-p-nitroanilideCo(II)-loaded enzyme; 12 µM CoCl20.590.069.8pH 7.5, 30 °CPMID 12755633Open
methionyl aminopeptidase (EcMetAP-I)Escherichia coliMet-Pro-p-nitroanilideFe(II)-loaded enzyme; 12 µM Fe(SO4)1.40.0916.8pH 7.5, 30 °CPMID 12755633Open
methionyl aminopeptidase (EcMetAP-I)variant H178AEscherichia coliMet-Gly-Met-MetCo(II)-loaded enzyme; 12 µM CoCl20.543.20.17pH 7.5PMID 12755633Open
methionyl aminopeptidase (EcMetAP-I)variant H178AEscherichia coliMet-Gly-Met-MetFe(II)-loaded enzyme; 12 µM Fe(SO4)0.5620.28pH 7.5PMID 12755633Open
methionyl aminopeptidase (EcMetAP-I)variant H178AEscherichia coliMet-Pro-p-nitroanilideCo(II)-loaded enzyme; 12 µM CoCl20.0020.120.015pH 7.5, 30 °CPMID 12755633Open
methionyl aminopeptidase (EcMetAP-I)variant H178AEscherichia coliMet-Pro-p-nitroanilideFe(II)-loaded enzyme; 12 µM Fe(SO4)0.010.130.085pH 7.5, 30 °CPMID 12755633Open
MtMetAP1a (methionine aminopeptidase, type Ia)Mycobacterium tuberculosisMet-Ala-Ser19.80.0181.1 × 10³ calc.pH 7.5, 37 °CPMID 19688379Open
MtMetAP1a (methionine aminopeptidase, type Ia)Mycobacterium tuberculosisMet-Gly-Met-Met11.50.32835.1 calc.pH 7.5, 37 °CPMID 19688379Open
MtMetAP1c (methionine aminopeptidase, type Ic)Mycobacterium tuberculosisMet-Ala-Ser74.30.394189 calc.pH 7.5, 37 °CPMID 19688379Open
MtMetAP1c (methionine aminopeptidase, type Ic)Mycobacterium tuberculosisMet-Gly-Met-Met39.40.058680 calc.pH 7.5, 37 °CPMID 19688379Open