EC 3.4.11.4: tripeptide aminopeptidase
HydrolasesOpen in Browse
CatLog read 42 records for EC 3.4.11.4 from 4 papers, for 4 organisms. Names in these papers: tripeptidase (aminotripeptidase), tripeptidase PepT (L9PepTR), leukotriene A4 hydrolase/aminopeptidase (LTA4H), Peptidase B (PepB).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 21 records for EC 3.4.11.4 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.11.4 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Substrate specificity of a tripeptidase as a metalloenzyme purified from Lactococcus lactis subsp. lactis biovar. diacetylactis ATCC 13675 | Lactococcus lactis subsp. lactis biovar. diacetylactis | 20 |
| Characterization and kinetic analysis of enzyme-substrate recognition by three recombinant lactococcal tripeptidases | Lactococcus lactis subsp. lactis | 10 |
| Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design | Homo sapiens | 6 |
| Characterization of two M17 family members in Escherichia coli, Peptidase A and Peptidase B | Escherichia coli | 6 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| leukotriene A4 hydrolase/aminopeptidase (LTA4H) | Homo sapiens | L-alanine 4-nitroanilide | 1.7 | 1.9 | 0.89 calc. | PMID 18804029 | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H), L-alanine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H) | Homo sapiens | L-arginine 4-nitroanilide | 1.9 | 1.5 | 1.3 calc. | PMID 18804029 | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H), L-arginine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H)variant D375A | Homo sapiens | L-alanine 4-nitroanilide | 0.5 | 3 | 0.17 calc. | PMID 18804029 | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H) variant D375A, L-alanine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H)variant D375A | Homo sapiens | L-arginine 4-nitroanilide | — | — | 0.05 | PMID 18804029 | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H) variant D375A, L-arginine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H)variant E296Q | Homo sapiens | L-alanine 4-nitroanilide | 0.001 | 1.9 | 5.3 × 10⁻⁴ calc. | PMID 18804029 | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H) variant E296Q, L-alanine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H)variant E296Q | Homo sapiens | L-arginine 4-nitroanilide | 0.002 | 2.2 | 9.1 × 10⁻⁴ calc. | PMID 18804029 | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H) variant E296Q, L-arginine 4-nitroanilide | |
| Peptidase B (PepB) | Escherichia coli | Ala-Ala-Phe-7-amido-4-methylcoumarin | 14.4 | 0.33 | 41 | pH 8, 37 °C | PMID 20350528 | Open record: Peptidase B (PepB), Ala-Ala-Phe-7-amido-4-methylcoumarin |
| Peptidase B (PepB) | Escherichia coli | glycine 7-amido-4-methylcoumarin | 12 | 0.16 | 71 | pH 8, 37 °C | PMID 20350528 | Open record: Peptidase B (PepB), glycine 7-amido-4-methylcoumarin |
| Peptidase B (PepB) | Escherichia coli | L-aspartic acid 7-amido-4-methylcoumarin | 11.7 | 0.401 | 23 | pH 8, 37 °C | PMID 20350528 | Open record: Peptidase B (PepB), L-aspartic acid 7-amido-4-methylcoumarin |
| Peptidase B (PepB) | Escherichia coli | L-leucine 7-amido-4-methylcoumarin | 19 | 0.14 | 112 | pH 8, 37 °C | PMID 20350528 | Open record: Peptidase B (PepB), L-leucine 7-amido-4-methylcoumarin |
| Peptidase B (PepB) | Escherichia coli | L-lysine 4-nitroanilide | 14.3 | 0.17 | 89 | pH 8, 37 °C | PMID 20350528 | Open record: Peptidase B (PepB), L-lysine 4-nitroanilide |
| Peptidase B (PepB) | Escherichia coli | L-methionine 7-amido-4-methylcoumarin | 14 | 0.14 | 104 | pH 8, 37 °C | PMID 20350528 | Open record: Peptidase B (PepB), L-methionine 7-amido-4-methylcoumarin |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Ala-Ala-Alanative enzyme as purified (naturally associated metal, zinc) | 144 | 0.154 | 935 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Ala-Ala-Ala |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Ala-Ala-Alaincubated with 1.0 mM Zn2+ (4 °C, 30 min) | 202 | 0.165 | 1.22 × 10³ | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Ala-Ala-Ala |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Ala-Ala-Alaincubated with 1.0 mM Co2+ (4 °C, 30 min) | 61.9 | 0.0778 | 796 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Ala-Ala-Ala |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Ala-Ala-Alaincubated with 1.0 mM Mn2+ (4 °C, 30 min) | 89.4 | 0.211 | 424 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Ala-Ala-Ala |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Ala-Alanative enzyme as purified (naturally associated metal, zinc) | 431 | 0.303 | 1.42 × 10³ | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Ala-Ala |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Ala-Alaincubated with 1.0 mM Zn2+ (4 °C, 30 min) | 467 | 0.36 | 1.3 × 10³ | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Ala-Ala |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Ala-Alaincubated with 1.0 mM Co2+ (4 °C, 30 min) | 283 | 0.267 | 1.06 × 10³ | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Ala-Ala |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Ala-Alaincubated with 1.0 mM Mn2+ (4 °C, 30 min) | 421 | 0.52 | 810 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Ala-Ala |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Ala-Tyrnative enzyme as purified (naturally associated metal, zinc) | 585 | 0.843 | 694 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Ala-Tyr |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Ala-Tyrincubated with 1.0 mM Zn2+ (4 °C, 30 min) | 682 | 0.766 | 890 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Ala-Tyr |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Ala-Tyrincubated with 1.0 mM Co2+ (4 °C, 30 min) | 209 | 0.293 | 713 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Ala-Tyr |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Ala-Tyrincubated with 1.0 mM Mn2+ (4 °C, 30 min) | 628 | 1.18 | 532 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Ala-Tyr |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Gly-Alanative enzyme as purified (naturally associated metal, zinc) | 399 | 0.819 | 487 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Gly-Ala |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Gly-Alaincubated with 1.0 mM Zn2+ (4 °C, 30 min) | 476 | 0.952 | 500 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Gly-Ala |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Gly-Alaincubated with 1.0 mM Co2+ (4 °C, 30 min) | 322 | 0.461 | 699 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Gly-Ala |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Gly-Alaincubated with 1.0 mM Mn2+ (4 °C, 30 min) | 489 | 1.35 | 362 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Gly-Ala |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Gly-Phenative enzyme as purified (naturally associated metal, zinc) | 405 | 3.5 | 116 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Gly-Phe |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Gly-Pheincubated with 1.0 mM Zn2+ (4 °C, 30 min) | 425 | 3.16 | 134 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Gly-Phe |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Gly-Pheincubated with 1.0 mM Co2+ (4 °C, 30 min) | 414 | 1.62 | 256 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Gly-Phe |
| tripeptidase (aminotripeptidase) | Lactococcus lactis subsp. lactis biovar. diacetylactis | Gly-Gly-Pheincubated with 1.0 mM Mn2+ (4 °C, 30 min) | 241 | 3.55 | 68 | pH 7.5, 37 °C | PMID 16233215 | Open record: tripeptidase (aminotripeptidase), Gly-Gly-Phe |
| tripeptidase PepT (L9PepTR) | Lactococcus lactis subsp. lactis | Ala-Ala-Ala | 163 | 0.147 | 1.11 × 10³ calc. | pH 7.5, 37 °C | PMID 15752689 | Open record: tripeptidase PepT (L9PepTR), Ala-Ala-Ala |
| tripeptidase PepT (L9PepTR) | Lactococcus lactis subsp. lactis | Ala-Gly-Gly | — | 1.57 | — | pH 7.5, 37 °C | PMID 15752689 | Open record: tripeptidase PepT (L9PepTR), Ala-Gly-Gly |
| tripeptidase PepT (L9PepTR) | Lactococcus lactis subsp. lactis | alpha-aminoisobutyryl-Gly-Gly | 31.2 | 10.6 | 2.93 | pH 7.5, 37 °C | PMID 15752689 | Open record: tripeptidase PepT (L9PepTR), alpha-aminoisobutyryl-Gly-Gly |
| tripeptidase PepT (L9PepTR) | Lactococcus lactis subsp. lactis | Gly-Ala-Gly | 1093 | — | — | pH 7.5, 37 °C | PMID 15752689 | Open record: tripeptidase PepT (L9PepTR), Gly-Ala-Gly |
| tripeptidase PepT (L9PepTR) | Lactococcus lactis subsp. lactis | Gly-Gly-Gly | — | 12 | — | pH 7.5, 37 °C | PMID 15752689 | Open record: tripeptidase PepT (L9PepTR), Gly-Gly-Gly |
| tripeptidase PepT (L9PepTR) | Lactococcus lactis subsp. lactis | Gly-Gly-Gly | — | — | 41.8 | pH 7.5, 37 °C | PMID 15752689 | Open record: tripeptidase PepT (L9PepTR), Gly-Gly-Gly |
| tripeptidase PepT (L9PepTR) | Lactococcus lactis subsp. lactis | Leu-Gly-Gly | 197 | 2.44 | 80.7 | pH 7.5, 37 °C | PMID 15752689 | Open record: tripeptidase PepT (L9PepTR), Leu-Gly-Gly |
| tripeptidase PepT (L9PepTR) | Lactococcus lactis subsp. lactis | Phe-Gly-Gly | 262 | 3.54 | 74.2 | pH 7.5, 37 °C | PMID 15752689 | Open record: tripeptidase PepT (L9PepTR), Phe-Gly-Gly |
| tripeptidase PepT (L9PepTR) | Lactococcus lactis subsp. lactis | Ser-Gly-Gly | 270 | 6.49 | 41.7 | pH 7.5, 37 °C | PMID 15752689 | Open record: tripeptidase PepT (L9PepTR), Ser-Gly-Gly |
| tripeptidase PepT (L9PepTR) | Lactococcus lactis subsp. lactis | Tyr-Gly-Gly | 292 | 1.77 | 165 | pH 7.5, 37 °C | PMID 15752689 | Open record: tripeptidase PepT (L9PepTR), Tyr-Gly-Gly |