Values CatLog read from this paper
Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design
PMID 18804029doi:10.1016/j.chembiol.2008.07.018Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 6 records (11 values) from this paper: leukotriene A4 hydrolase/aminopeptidase (LTA4H) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 5 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| leukotriene A4 hydrolase/aminopeptidase (LTA4H) | Homo sapiens | L-alanine 4-nitroanilide | 1.7 | 1.9 | 0.89 calc. | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H), L-alanine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H) | Homo sapiens | L-arginine 4-nitroanilide | 1.9 | 1.5 | 1.3 calc. | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H), L-arginine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H)variant D375A | Homo sapiens | L-alanine 4-nitroanilide | 0.5 | 3 | 0.17 calc. | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H) variant D375A, L-alanine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H)variant D375A | Homo sapiens | L-arginine 4-nitroanilide | — | — | 0.05 | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H) variant D375A, L-arginine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H)variant E296Q | Homo sapiens | L-alanine 4-nitroanilide | 0.001 | 1.9 | 5.3 × 10⁻⁴ calc. | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H) variant E296Q, L-alanine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H)variant E296Q | Homo sapiens | L-arginine 4-nitroanilide | 0.002 | 2.2 | 9.1 × 10⁻⁴ calc. | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H) variant E296Q, L-arginine 4-nitroanilide |