EC 3.3.2.6: leukotriene-A4 hydrolase
HydrolasesOpen in Browse
CatLog read 57 records for EC 3.3.2.6 from 4 papers, for 3 organisms. Names in these papers: leukotriene A4 hydrolase (aminopeptidase activity), leukotriene A4 hydrolase, leukotriene A4 hydrolase/aminopeptidase (LTA4H), leukotriene A4 hydrolase (xlLTA4H).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 35 records for EC 3.3.2.6 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.3.2.6 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Asparagine362 is essential for zinc binding and catalysis in the peptidase reaction of Saccharomyces cerevisiae leukotriene A₄ hydrolase | Saccharomyces cerevisiae | 32 |
| Leukotriene A4 hydrolase: an anion activated peptidase | Homo sapiens | 15 |
| Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design | Homo sapiens | 6 |
| Product formation controlled by substrate dynamics in leukotriene A4 hydrolase | Xenopus laevis | 4 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| leukotriene A4 hydrolase | Homo sapiens | alanine-4-nitroanilide | 0.6 | 0.5 | 1.2 calc. | pH 7.6 | PMID 1536866 | Open record: leukotriene A4 hydrolase, alanine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | alanine-4-nitroanilide12.5 mM NaCl | 0.15 | 1.1 | 0.14 | pH 7.5 | PMID 1536866 | Open record: leukotriene A4 hydrolase, alanine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | alanine-4-nitroanilide25 mM NaCl | 0.2 | 1.1 | 0.18 | pH 7.5 | PMID 1536866 | Open record: leukotriene A4 hydrolase, alanine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | alanine-4-nitroanilide50 mM NaCl | 0.4 | 1.1 | 0.36 | pH 7.5 | PMID 1536866 | Open record: leukotriene A4 hydrolase, alanine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | alanine-4-nitroanilide100 mM NaCl | 0.6 | 1.1 | 0.55 | pH 7.5 | PMID 1536866 | Open record: leukotriene A4 hydrolase, alanine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | alanine-4-nitroanilide200 mM NaCl | 0.7 | 0.9 | 0.78 | pH 7.5 | PMID 1536866 | Open record: leukotriene A4 hydrolase, alanine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | alanine-4-nitroanilide12.5 mM NaSCN | 0.6 | 1.1 | 0.55 | pH 7.5 | PMID 1536866 | Open record: leukotriene A4 hydrolase, alanine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | alanine-4-nitroanilide25 mM NaSCN | 1.2 | 1.3 | 0.92 | pH 7.5 | PMID 1536866 | Open record: leukotriene A4 hydrolase, alanine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | alanine-4-nitroanilide50 mM NaSCN | 1.7 | 1.1 | 1.55 | pH 7.5 | PMID 1536866 | Open record: leukotriene A4 hydrolase, alanine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | alanine-4-nitroanilide100 mM NaSCN | 2.3 | 1.3 | 1.77 | pH 7.5 | PMID 1536866 | Open record: leukotriene A4 hydrolase, alanine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | alanine-4-nitroanilide200 mM NaSCN | 2.4 | 1.3 | 1.85 | pH 7.5 | PMID 1536866 | Open record: leukotriene A4 hydrolase, alanine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | arginine-4-nitroanilide | 0.15 | 0.2 | 0.75 | pH 7.6 | PMID 1536866 | Open record: leukotriene A4 hydrolase, arginine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | leucine-4-nitroanilide | 0.15 | 0.3 | 0.5 | pH 7.6 | PMID 1536866 | Open record: leukotriene A4 hydrolase, leucine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | lysine-4-nitroanilide | 0.04 | 0.1 | 0.4 | pH 7.6 | PMID 1536866 | Open record: leukotriene A4 hydrolase, lysine-4-nitroanilide |
| leukotriene A4 hydrolase | Homo sapiens | proline-4-nitroanilide | 0.15 | 0.1 | 1.5 calc. | pH 7.6 | PMID 1536866 | Open record: leukotriene A4 hydrolase, proline-4-nitroanilide |
| leukotriene A4 hydrolase (aminopeptidase activity) | Saccharomyces cerevisiae | alanine β-naphthylamide | 0.027 | 1.78 | 0.015 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity), alanine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity) | Saccharomyces cerevisiae | arginine β-naphthylamide | 0.0152 | 0.366 | 0.0410 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity), arginine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity) | Saccharomyces cerevisiae | isoleucine β-naphthylamide | 0.0145 | 0.566 | 0.0260 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity), isoleucine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity) | Saccharomyces cerevisiae | leucine β-naphthylamide | 0.147 | 0.745 | 0.200 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity), leucine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity) | Saccharomyces cerevisiae | methionine β-naphthylamide | 0.147 | 0.7 | 0.21 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity), methionine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity) | Saccharomyces cerevisiae | valine β-naphthylamide | 0.0193 | 0.384 | 0.0503 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity), valine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant D399A | Saccharomyces cerevisiae | alanine β-naphthylamide | 0.065 | 0.885 | 0.073 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant D399A, alanine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant D399A | Saccharomyces cerevisiae | arginine β-naphthylamide | 0.023 | 0.199 | 0.12 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant D399A, arginine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant D399A | Saccharomyces cerevisiae | isoleucine β-naphthylamide | 0.0168 | 0.657 | 0.0256 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant D399A, isoleucine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant D399A | Saccharomyces cerevisiae | leucine β-naphthylamide | 0.165 | 0.693 | 0.240 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant D399A, leucine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant D399A | Saccharomyces cerevisiae | methionine β-naphthylamide | 0.098 | 0.374 | 0.26 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant D399A, methionine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant D399A | Saccharomyces cerevisiae | valine β-naphthylamide | 0.0242 | 0.803 | 0.0301 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant D399A, valine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362E | Saccharomyces cerevisiae | alanine β-naphthylamide | 0.003 | 0.618 | 0.0049 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362E, alanine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362E | Saccharomyces cerevisiae | arginine β-naphthylamide | 0.005 | 0.587 | 0.0085 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362E, arginine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362E | Saccharomyces cerevisiae | leucine β-naphthylamide | 0.0065 | 0.365 | 0.018 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362E, leucine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362E | Saccharomyces cerevisiae | methionine β-naphthylamide | 0.0087 | 0.166 | 0.052 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362E, methionine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362L | Saccharomyces cerevisiae | alanine β-naphthylamide | 4.7 × 10⁻⁴ | 0.31 | 0.0015 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362L, alanine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362L | Saccharomyces cerevisiae | arginine β-naphthylamide | 2.8 × 10⁻⁴ | 0.49 | 5.8 × 10⁻⁴ calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362L, arginine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362L | Saccharomyces cerevisiae | leucine β-naphthylamide | 0.00135 | 0.29 | 0.0047 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362L, leucine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362L | Saccharomyces cerevisiae | methionine β-naphthylamide | 0.0032 | 0.128 | 0.025 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362L, methionine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362Q | Saccharomyces cerevisiae | alanine β-naphthylamide | 0.0128 | 0.4 | 0.032 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362Q, alanine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362Q | Saccharomyces cerevisiae | arginine β-naphthylamide | 0.0123 | 0.137 | 0.0900 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362Q, arginine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362Q | Saccharomyces cerevisiae | isoleucine β-naphthylamide | 0.0085 | 0.698 | 0.012 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362Q, isoleucine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362Q | Saccharomyces cerevisiae | leucine β-naphthylamide | 0.006 | 0.105 | 0.057 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362Q, leucine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362Q | Saccharomyces cerevisiae | methionine β-naphthylamide | 0.0265 | 0.15 | 0.18 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362Q, methionine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant N362Q | Saccharomyces cerevisiae | valine β-naphthylamide | 0.0037 | 0.235 | 0.016 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant N362Q, valine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant W365L | Saccharomyces cerevisiae | alanine β-naphthylamide | 0.1088 | 0.339 | 0.321 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant W365L, alanine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant W365L | Saccharomyces cerevisiae | arginine β-naphthylamide | 0.0388 | 0.275 | 0.141 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant W365L, arginine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant W365L | Saccharomyces cerevisiae | isoleucine β-naphthylamide | 0.0268 | 0.488 | 0.0550 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant W365L, isoleucine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant W365L | Saccharomyces cerevisiae | leucine β-naphthylamide | 0.225 | 0.771 | 0.292 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant W365L, leucine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant W365L | Saccharomyces cerevisiae | methionine β-naphthylamide | 0.1588 | 0.351 | 0.453 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant W365L, methionine β-naphthylamide |
| leukotriene A4 hydrolase (aminopeptidase activity)variant W365L | Saccharomyces cerevisiae | valine β-naphthylamide | 0.0343 | 0.808 | 0.0425 calc. | 25 °C | PMID 20624488 | Open record: leukotriene A4 hydrolase (aminopeptidase activity) variant W365L, valine β-naphthylamide |
| leukotriene A4 hydrolase (xlLTA4H) | Xenopus laevis | alanine-4-nitroanilide | 4.3 | 2.6 | 1.7 | pH 7.8 | PMID 24333438 | Open record: leukotriene A4 hydrolase (xlLTA4H), alanine-4-nitroanilide |
| leukotriene A4 hydrolase (xlLTA4H) | Xenopus laevis | leukotriene A4, 5(S)-trans-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid | 20.1 | 0.045 | 450 | pH 7.8 | PMID 24333438 | Open record: leukotriene A4 hydrolase (xlLTA4H), leukotriene A4, 5(S)-trans-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid |
| leukotriene A4 hydrolase (xlLTA4H)variant F375Y | Xenopus laevis | alanine-4-nitroanilide | 3.44 | 0.87 | 3.96 | pH 7.8 | PMID 24333438 | Open record: leukotriene A4 hydrolase (xlLTA4H) variant F375Y, alanine-4-nitroanilide |
| leukotriene A4 hydrolase (xlLTA4H)variant F375Y | Xenopus laevis | leukotriene A4, 5(S)-trans-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid | 3.1 | 0.004 | 800 | pH 7.8 | PMID 24333438 | Open record: leukotriene A4 hydrolase (xlLTA4H) variant F375Y, leukotriene A4, 5(S)-trans-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H) | Homo sapiens | L-alanine 4-nitroanilide | 1.7 | 1.9 | 0.89 calc. | PMID 18804029 | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H), L-alanine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H) | Homo sapiens | L-arginine 4-nitroanilide | 1.9 | 1.5 | 1.3 calc. | PMID 18804029 | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H), L-arginine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H)variant D375A | Homo sapiens | L-alanine 4-nitroanilide | 0.5 | 3 | 0.17 calc. | PMID 18804029 | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H) variant D375A, L-alanine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H)variant D375A | Homo sapiens | L-arginine 4-nitroanilide | — | — | 0.05 | PMID 18804029 | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H) variant D375A, L-arginine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H)variant E296Q | Homo sapiens | L-alanine 4-nitroanilide | 0.001 | 1.9 | 5.3 × 10⁻⁴ calc. | PMID 18804029 | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H) variant E296Q, L-alanine 4-nitroanilide | |
| leukotriene A4 hydrolase/aminopeptidase (LTA4H)variant E296Q | Homo sapiens | L-arginine 4-nitroanilide | 0.002 | 2.2 | 9.1 × 10⁻⁴ calc. | PMID 18804029 | Open record: leukotriene A4 hydrolase/aminopeptidase (LTA4H) variant E296Q, L-arginine 4-nitroanilide |