CatLogenzyme kinetics catalog

EC 3.4.14.9: tripeptidyl-peptidase I

HydrolasesOpen in Browse

CatLog read 27 records for EC 3.4.14.9 from 3 papers, for 1 organism. Names in these papers: tripeptidyl peptidase I (TPP-I, CLN2), tripeptidyl peptidase I (TPP-I, CLN2p), tripeptidyl-peptidase I (TPP I, CLN2 protein).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 6 records for EC 3.4.14.9 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.14.9 in Browse.

Papers

PaperOrganismsRecords
Catalytic residues and substrate specificity of recombinant human tripeptidyl peptidase I (CLN2)Homo sapiens13
Analysis of catalytic properties of tripeptidyl peptidase I (TTP-I), a serine carboxyl lysosomal protease, and its detection in tissue extracts using selective FRET peptide substrateHomo sapiens8
Ser475, Glu272, Asp276, Asp327, and Asp360 are involved in catalytic activity of human tripeptidyl-peptidase IHomo sapiens6

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
tripeptidyl peptidase I (TPP-I, CLN2)Homo sapiensAla-Ala-Ala-Phe-p-nitrophenylalanine-Arg-Leu——150pH 4, 37 °CPMID 16091586Open
tripeptidyl peptidase I (TPP-I, CLN2)Homo sapiensAla-Ala-Phe-7-amido-4-methylcoumarin——68pH 4, 37 °CPMID 16091586Open
tripeptidyl peptidase I (TPP-I, CLN2)Homo sapiensAla-Ala-Phe-p-nitrophenylalanine-Arg-Leu34.50.01482.33 × 10³pH 4, 37 °CPMID 16091586Open
tripeptidyl peptidase I (TPP-I, CLN2)Homo sapiensAla-Arg-Phe-p-nitrophenylalanine-Arg-Leu11.80.004022.94 × 10³pH 4, 37 °CPMID 16091586Open
tripeptidyl peptidase I (TPP-I, CLN2)Homo sapiensAla-Asp-Phe-p-nitrophenylalanine-Arg-Leu110.005092.16 × 10³pH 4, 37 °CPMID 16091586Open
tripeptidyl peptidase I (TPP-I, CLN2)Homo sapiensAla-His-Phe-p-nitrophenylalanine-Arg-Leu26.40.0422630pH 4, 37 °CPMID 16091586Open
tripeptidyl peptidase I (TPP-I, CLN2)Homo sapiensAla-Ser-Phe-p-nitrophenylalanine-Arg-Leu30.70.0483640pH 4, 37 °CPMID 16091586Open
tripeptidyl peptidase I (TPP-I, CLN2)Homo sapiensArg-Ala-Phe-p-nitrophenylalanine-Arg-Leu0.910.019347pH 4, 37 °CPMID 16091586Open
tripeptidyl peptidase I (TPP-I, CLN2)Homo sapiensAsp-Ala-Phe-p-nitrophenylalanine-Arg-Leu18.50.11170pH 4, 37 °CPMID 16091586Open
tripeptidyl peptidase I (TPP-I, CLN2)Homo sapiensHis-Ala-Phe-p-nitrophenylalanine-Arg-Leu13.70.16782pH 4, 37 °CPMID 16091586Open
tripeptidyl peptidase I (TPP-I, CLN2)Homo sapiensLys-Pro-Ile-Ala-Phe-p-nitrophenylalanine-Arg-Leu0.680.2882.4pH 4, 37 °CPMID 16091586Open
tripeptidyl peptidase I (TPP-I, CLN2)Homo sapiensSer-Ala-Phe-p-nitrophenylalanine-Arg-Leu4.70.10844pH 4, 37 °CPMID 16091586Open
tripeptidyl peptidase I (TPP-I, CLN2)variant E77AHomo sapiensAla-Arg-Phe-p-nitrophenylalanine-Arg-Leu0.01240.1230.1pH 4, 37 °CPMID 16091586Open
tripeptidyl peptidase I (TPP-I, CLN2p)Homo sapiensacetyl-Arg-Trp-Phe-Phe-Ile-glutaminyl-[N-(2,4-dinitrophenyl)-ethylenediamine]0.10.0333pH 4.3, 37 °CPMID 26775801Open
tripeptidyl peptidase I (TPP-I, CLN2p)Homo sapiensArg-Trp-Phe-Phe-Ile-glutaminyl-[N-(2,4-dinitrophenyl)-ethylenediamine]5.047 × 10⁻⁴7.2 × 10³pH 4.3, 37 °CPMID 26775801Open
tripeptidyl peptidase I (TPP-I, CLN2p)Homo sapiensArg-Trp-Phe-Val-Ile-glutaminyl-[N-(2,4-dinitrophenyl)-ethylenediamine]1.55.5 × 10⁻⁴2727pH 4.3, 37 °CPMID 26775801Open
tripeptidyl peptidase I (TPP-I, CLN2p)Homo sapiensepsilon-aminocaproyl-Trp-Phe-Phe-Ile-glutaminyl-[N-(2,4-dinitrophenyl)-ethylenediamine]0.069.5 × 10⁻⁴63.2pH 4.3, 37 °CPMID 26775801Open
tripeptidyl peptidase I (TPP-I, CLN2p)Homo sapiensLys-Trp-Phe-Phe-Ile-glutaminyl-[N-(2,4-dinitrophenyl)-ethylenediamine]27 × 10⁻⁴2857pH 4.3, 37 °CPMID 26775801Open
tripeptidyl peptidase I (TPP-I, CLN2p)Homo sapiensMCA-KLFFSKQ-EDDnp0.0060.001474.1pH 4.3, 37 °CPMID 26775801Open
tripeptidyl peptidase I (TPP-I, CLN2p)Homo sapiensMCA-KLFSSKQ-EDDnp0.00340.0040.85pH 4.3, 37 °CPMID 26775801Open
tripeptidyl peptidase I (TPP-I, CLN2p)Homo sapiensNH2-AAF-MCA0.390.02218pH 4.3, 37 °CPMID 26775801Open
tripeptidyl-peptidase I (TPP I, CLN2 protein)Homo sapiensAla-Ala-Phe-7-amino-4-methylcoumarin41.660.098425.1pH 5, 37 °CPMID 15733845Open
tripeptidyl-peptidase I (TPP I, CLN2 protein)variant D276AHomo sapiensAla-Ala-Phe-7-amino-4-methylcoumarin9.360.10589.14pH 5, 37 °CPMID 15733845Open
tripeptidyl-peptidase I (TPP I, CLN2 protein)variant D327AHomo sapiensAla-Ala-Phe-7-amino-4-methylcoumarin4.220.16425.73pH 5, 37 °CPMID 15733845Open
tripeptidyl-peptidase I (TPP I, CLN2 protein)variant D360AHomo sapiensAla-Ala-Phe-7-amino-4-methylcoumarin1.520.11112.69pH 5, 37 °CPMID 15733845Open
tripeptidyl-peptidase I (TPP I, CLN2 protein)variant E272AHomo sapiensAla-Ala-Phe-7-amino-4-methylcoumarin1.540.11813.05pH 5, 37 °CPMID 15733845Open
tripeptidyl-peptidase I (TPP I, CLN2 protein)variant S475LHomo sapiensAla-Ala-Phe-7-amino-4-methylcoumarin0.120.0761.58pH 5, 37 °CPMID 15733845Open