EC 3.4.19.3: pyroglutamyl-peptidase I
HydrolasesOpen in Browse
CatLog read 28 records for EC 3.4.19.3 from 2 papers, for 4 organisms. Names in these papers: pyroglutamyl aminopeptidase I (PAP-I), pyroglutamyl peptidase type I (PGP).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 23 records for EC 3.4.19.3 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.19.3 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Pyroglutamyl aminopeptidase I, as a drug metabolizing enzyme, recognizes xenobiotic substrates containing L-2-oxothiazolidine-4-carboxylic acid | Homo sapiens, Mus musculus and 1 more | 20 |
| Pyroglutamyl peptidase type I from Trypanosoma brucei: a new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts | Trypanosoma brucei brucei | 8 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| pyroglutamyl aminopeptidase I (PAP-I) | Homo sapiens | 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide | 1.8 | 0.5 | 3.7 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide |
| pyroglutamyl aminopeptidase I (PAP-I) | Homo sapiens | L-2-oxoimidazolidine-4-carbonyl-L-alanine | 2.4 | 0.33 | 7.2 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-2-oxoimidazolidine-4-carbonyl-L-alanine |
| pyroglutamyl aminopeptidase I (PAP-I) | Homo sapiens | L-2-oxooxazolidine-4-carbonyl-L-alanine | 6.4 | 0.55 | 11.5 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-2-oxooxazolidine-4-carbonyl-L-alanine |
| pyroglutamyl aminopeptidase I (PAP-I) | Homo sapiens | L-2-oxothiazolidine-4-carbonyl-L-alanine | 2.3 | 0.3 | 7.6 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-2-oxothiazolidine-4-carbonyl-L-alanine |
| pyroglutamyl aminopeptidase I (PAP-I) | Homo sapiens | L-pyroglutamyl-L-alanine | 2.4 | 0.045 | 53.3 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-pyroglutamyl-L-alanine |
| pyroglutamyl aminopeptidase I (PAP-I) | Mus musculus | 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide | 2.3 | 0.58 | 3.9 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide |
| pyroglutamyl aminopeptidase I (PAP-I) | Mus musculus | L-2-oxoimidazolidine-4-carbonyl-L-alanine | 2.7 | 0.37 | 7.2 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-2-oxoimidazolidine-4-carbonyl-L-alanine |
| pyroglutamyl aminopeptidase I (PAP-I) | Mus musculus | L-2-oxooxazolidine-4-carbonyl-L-alanine | 6.6 | 0.57 | 11.7 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-2-oxooxazolidine-4-carbonyl-L-alanine |
| pyroglutamyl aminopeptidase I (PAP-I) | Mus musculus | L-2-oxothiazolidine-4-carbonyl-L-alanine | 2.5 | 0.33 | 7.5 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-2-oxothiazolidine-4-carbonyl-L-alanine |
| pyroglutamyl aminopeptidase I (PAP-I) | Mus musculus | L-pyroglutamyl-L-alanine | 3.2 | 0.046 | 70.3 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-pyroglutamyl-L-alanine |
| pyroglutamyl aminopeptidase I (PAP-I) | Rattus norvegicus | 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide | 2.3 | 0.55 | 4.2 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), 4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide |
| pyroglutamyl aminopeptidase I (PAP-I) | Rattus norvegicus | L-2-oxoimidazolidine-4-carbonyl-L-alanine | 3.6 | 0.42 | 8.4 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-2-oxoimidazolidine-4-carbonyl-L-alanine |
| pyroglutamyl aminopeptidase I (PAP-I) | Rattus norvegicus | L-2-oxooxazolidine-4-carbonyl-aminoethylnitrate | 7.6 | 1.53 | 5 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-2-oxooxazolidine-4-carbonyl-aminoethylnitrate |
| pyroglutamyl aminopeptidase I (PAP-I) | Rattus norvegicus | L-2-oxooxazolidine-4-carbonyl-L-alanine | 8.1 | 0.71 | 11.3 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-2-oxooxazolidine-4-carbonyl-L-alanine |
| pyroglutamyl aminopeptidase I (PAP-I) | Rattus norvegicus | L-2-oxothiazolidine-4-carbonyl-D-2-aminopropylnitrate | 1.5 | 1.43 | 1 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-2-oxothiazolidine-4-carbonyl-D-2-aminopropylnitrate |
| pyroglutamyl aminopeptidase I (PAP-I) | Rattus norvegicus | L-2-oxothiazolidine-4-carbonyl-ethanolamine | 0.9 | 0.62 | 1.5 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-2-oxothiazolidine-4-carbonyl-ethanolamine |
| pyroglutamyl aminopeptidase I (PAP-I) | Rattus norvegicus | L-2-oxothiazolidine-4-carbonyl-L-2-aminopropylnitrate | 3.2 | 0.57 | 5.5 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-2-oxothiazolidine-4-carbonyl-L-2-aminopropylnitrate |
| pyroglutamyl aminopeptidase I (PAP-I) | Rattus norvegicus | L-2-oxothiazolidine-4-carbonyl-L-alanine | 3.4 | 0.43 | 7.8 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-2-oxothiazolidine-4-carbonyl-L-alanine |
| pyroglutamyl aminopeptidase I (PAP-I) | Rattus norvegicus | L-pyroglutamyl-aminoethylnitrate | 3.5 | 0.14 | 24.1 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-pyroglutamyl-aminoethylnitrate |
| pyroglutamyl aminopeptidase I (PAP-I) | Rattus norvegicus | L-pyroglutamyl-L-alanine | 3.7 | 0.057 | 64.2 | pH 7.4, 37 °C | PMID 14709911 | Open record: pyroglutamyl aminopeptidase I (PAP-I), L-pyroglutamyl-L-alanine |
| pyroglutamyl peptidase type I (PGP) | Trypanosoma brucei brucei | gonadotropin-releasing hormone, Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 | 9 | 0.079 | 100 | pH 7.4, 37 °C | PMID 16248854 | Open record: pyroglutamyl peptidase type I (PGP), gonadotropin-releasing hormone, Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 |
| pyroglutamyl peptidase type I (PGP) | Trypanosoma brucei brucei | gonadotropin-releasing hormone, Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2recombinant | 12 | 0.089 | 100 | pH 7.4, 37 °C | PMID 16248854 | Open record: pyroglutamyl peptidase type I (PGP), gonadotropin-releasing hormone, Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 |
| pyroglutamyl peptidase type I (PGP) | Trypanosoma brucei brucei | L-pyroglutamyl p-nitroanilide | 52 | 0.028 | 1.9 × 10³ | pH 7.4, 37 °C | PMID 16248854 | Open record: pyroglutamyl peptidase type I (PGP), L-pyroglutamyl p-nitroanilide |
| pyroglutamyl peptidase type I (PGP) | Trypanosoma brucei brucei | L-pyroglutamyl p-nitroaniliderecombinant | 64 | 0.044 | 1.5 × 10³ | pH 7.4, 37 °C | PMID 16248854 | Open record: pyroglutamyl peptidase type I (PGP), L-pyroglutamyl p-nitroanilide |
| pyroglutamyl peptidase type I (PGP) | Trypanosoma brucei brucei | L-pyroglutamyl-7-amido-4-methylcoumarin | 58 | 0.018 | 3.2 × 10³ | pH 7.4, 37 °C | PMID 16248854 | Open record: pyroglutamyl peptidase type I (PGP), L-pyroglutamyl-7-amido-4-methylcoumarin |
| pyroglutamyl peptidase type I (PGP) | Trypanosoma brucei brucei | L-pyroglutamyl-7-amido-4-methylcoumarinrecombinant | 47 | 0.028 | 1.7 × 10³ | pH 7.4, 37 °C | PMID 16248854 | Open record: pyroglutamyl peptidase type I (PGP), L-pyroglutamyl-7-amido-4-methylcoumarin |
| pyroglutamyl peptidase type I (PGP) | Trypanosoma brucei brucei | thyrotrophin-releasing hormone, Glp-His-Pro-NH2 | 20 | 0.041 | 500 | pH 7.4, 37 °C | PMID 16248854 | Open record: pyroglutamyl peptidase type I (PGP), thyrotrophin-releasing hormone, Glp-His-Pro-NH2 |
| pyroglutamyl peptidase type I (PGP) | Trypanosoma brucei brucei | thyrotrophin-releasing hormone, Glp-His-Pro-NH2recombinant | 22 | 0.032 | 700 | pH 7.4, 37 °C | PMID 16248854 | Open record: pyroglutamyl peptidase type I (PGP), thyrotrophin-releasing hormone, Glp-His-Pro-NH2 |