EC 3.4.21.118: kallikrein 8
HydrolasesOpen in Browse
CatLog read 17 records for EC 3.4.21.118 from 2 papers, for 1 organism. Names in these papers: mat-KLK8 (mature kallikrein-related peptidase-8), human kallikrein 8 (hK8).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 3 records for EC 3.4.21.118 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.21.118 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade | Homo sapiens | 11 |
| Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins | Homo sapiens | 6 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| human kallikrein 8 (hK8) | Homo sapiens | benzyloxycarbonyl-Val-Val-Arg 4-methylcoumaryl-7-amide | 2.3 | 0.07 | 33 | 37 °C | PMID 16337200 | Open record: human kallikrein 8 (hK8), benzyloxycarbonyl-Val-Val-Arg 4-methylcoumaryl-7-amide |
| human kallikrein 8 (hK8) | Homo sapiens | Pro-Phe-Arg 4-methylcoumaryl-7-amide | 3 | 0.07 | 43 | 37 °C | PMID 16337200 | Open record: human kallikrein 8 (hK8), Pro-Phe-Arg 4-methylcoumaryl-7-amide |
| human kallikrein 8 (hK8) | Homo sapiens | tert-butyloxycarbonyl-Leu-Lys-Arg 4-methylcoumaryl-7-amide | 1.08 | 0.1 | 10.8 | 37 °C | PMID 16337200 | Open record: human kallikrein 8 (hK8), tert-butyloxycarbonyl-Leu-Lys-Arg 4-methylcoumaryl-7-amide |
| human kallikrein 8 (hK8) | Homo sapiens | tert-butyloxycarbonyl-Phe-Ser-Arg 4-methylcoumaryl-7-amide | 0.67 | 0.07 | 9.5 | 37 °C | PMID 16337200 | Open record: human kallikrein 8 (hK8), tert-butyloxycarbonyl-Phe-Ser-Arg 4-methylcoumaryl-7-amide |
| human kallikrein 8 (hK8) | Homo sapiens | tert-butyloxycarbonyl-Val-Leu-Lys 4-methylcoumaryl-7-amide | 0.8 | 0.1 | 8 | 37 °C | PMID 16337200 | Open record: human kallikrein 8 (hK8), tert-butyloxycarbonyl-Val-Leu-Lys 4-methylcoumaryl-7-amide |
| human kallikrein 8 (hK8) | Homo sapiens | tert-butyloxycarbonyl-Val-Pro-Arg 4-methylcoumaryl-7-amide | 1.63 | 0.07 | 23 | 37 °C | PMID 16337200 | Open record: human kallikrein 8 (hK8), tert-butyloxycarbonyl-Val-Pro-Arg 4-methylcoumaryl-7-amide |
| mat-KLK8 (mature kallikrein-related peptidase-8) | Homo sapiens | benzyloxycarbonyl-glycyl-glycyl-L-arginine-7-amino-4-methylcoumarin | 1.488 | 0.4312 | 3.452 | pH 8.5, 37 °C | PMID 20940292 | Open record: mat-KLK8 (mature kallikrein-related peptidase-8), benzyloxycarbonyl-glycyl-glycyl-L-arginine-7-amino-4-methylcoumarin |
| mat-KLK8 (mature kallikrein-related peptidase-8) | Homo sapiens | L-prolyl-L-phenylalanyl-L-arginine-7-amino-4-methylcoumarin (free N terminus) | 4.448 | 0.1533 | 29.02 | pH 8.5, 37 °C | PMID 20940292 | Open record: mat-KLK8 (mature kallikrein-related peptidase-8), L-prolyl-L-phenylalanyl-L-arginine-7-amino-4-methylcoumarin (free N terminus) |
| mat-KLK8 (mature kallikrein-related peptidase-8) | Homo sapiens | N-t-butoxycarbonyl-L-glutaminyl-glycyl-L-arginine-7-amino-4-methylcoumarin | 1.429 | 0.3699 | 3.864 | pH 8.5, 37 °C | PMID 20940292 | Open record: mat-KLK8 (mature kallikrein-related peptidase-8), N-t-butoxycarbonyl-L-glutaminyl-glycyl-L-arginine-7-amino-4-methylcoumarin |
| mat-KLK8 (mature kallikrein-related peptidase-8) | Homo sapiens | N-t-butoxycarbonyl-L-glutaminyl-L-alanyl-L-arginine-7-amino-4-methylcoumarin | 5.754 | 0.1844 | 31.20 | pH 8.5, 37 °C | PMID 20940292 | Open record: mat-KLK8 (mature kallikrein-related peptidase-8), N-t-butoxycarbonyl-L-glutaminyl-L-alanyl-L-arginine-7-amino-4-methylcoumarin |
| mat-KLK8 (mature kallikrein-related peptidase-8) | Homo sapiens | N-t-butoxycarbonyl-L-glutaminyl-L-arginyl-L-arginine-7-amino-4-methylcoumarin | 3.392 | 0.2247 | 15.10 | pH 8.5, 37 °C | PMID 20940292 | Open record: mat-KLK8 (mature kallikrein-related peptidase-8), N-t-butoxycarbonyl-L-glutaminyl-L-arginyl-L-arginine-7-amino-4-methylcoumarin |
| mat-KLK8 (mature kallikrein-related peptidase-8) | Homo sapiens | N-t-butoxycarbonyl-L-leucyl-L-arginyl-L-arginine-7-amino-4-methylcoumarin | 1.620 | 0.1165 | 13.91 | pH 8.5, 37 °C | PMID 20940292 | Open record: mat-KLK8 (mature kallikrein-related peptidase-8), N-t-butoxycarbonyl-L-leucyl-L-arginyl-L-arginine-7-amino-4-methylcoumarin |
| mat-KLK8 (mature kallikrein-related peptidase-8) | Homo sapiens | N-t-butoxycarbonyl-L-leucyl-L-lysyl-L-arginine-7-amino-4-methylcoumarin | 1.565 | 0.1407 | 11.12 | pH 8.5, 37 °C | PMID 20940292 | Open record: mat-KLK8 (mature kallikrein-related peptidase-8), N-t-butoxycarbonyl-L-leucyl-L-lysyl-L-arginine-7-amino-4-methylcoumarin |
| mat-KLK8 (mature kallikrein-related peptidase-8) | Homo sapiens | N-t-butoxycarbonyl-L-phenylalanyl-L-seryl-L-arginine-7-amino-4-methylcoumarin | 3.566 | 0.2983 | 11.96 | pH 8.5, 37 °C | PMID 20940292 | Open record: mat-KLK8 (mature kallikrein-related peptidase-8), N-t-butoxycarbonyl-L-phenylalanyl-L-seryl-L-arginine-7-amino-4-methylcoumarin |
| mat-KLK8 (mature kallikrein-related peptidase-8) | Homo sapiens | N-t-butoxycarbonyl-L-valyl-L-leucyl-L-lysine-7-amino-4-methylcoumarin | 3.637 | 0.3326 | 10.94 | pH 8.5, 37 °C | PMID 20940292 | Open record: mat-KLK8 (mature kallikrein-related peptidase-8), N-t-butoxycarbonyl-L-valyl-L-leucyl-L-lysine-7-amino-4-methylcoumarin |
| mat-KLK8 (mature kallikrein-related peptidase-8) | Homo sapiens | N-t-butoxycarbonyl-L-valyl-L-prolyl-L-arginine-7-amino-4-methylcoumarin | 6.756 | 0.0238 | 283.4 | pH 8.5, 37 °C | PMID 20940292 | Open record: mat-KLK8 (mature kallikrein-related peptidase-8), N-t-butoxycarbonyl-L-valyl-L-prolyl-L-arginine-7-amino-4-methylcoumarin |
| mat-KLK8 (mature kallikrein-related peptidase-8) | Homo sapiens | N-tosyl-glycyl-L-prolyl-L-arginine-7-amino-4-methylcoumarin | 2.106 | 0.6897 | 3.054 | pH 8.5, 37 °C | PMID 20940292 | Open record: mat-KLK8 (mature kallikrein-related peptidase-8), N-tosyl-glycyl-L-prolyl-L-arginine-7-amino-4-methylcoumarin |