EC 3.4.21.2: chymotrypsin C
HydrolasesOpen in Browse
CatLog read 36 records for EC 3.4.21.2 from 3 papers, for 1 organism. Names in these papers: chymotrypsin C (CTRC), chymotrypsin C.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 3 records for EC 3.4.21.2 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.21.2 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk | Homo sapiens | 14 |
| Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis | Homo sapiens | 12 |
| Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen | Homo sapiens | 10 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| chymotrypsin C | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 15 | 0.0135 | 1.1 × 10³ | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin Cvariant A73T | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 16.6 | 0.0244 | 680 | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C variant A73T, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin Cvariant D35Y | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 11.7 | 0.0171 | 680 | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C variant D35Y, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin Cvariant G18R | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 15.7 | 0.017 | 920 | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C variant G18R, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin Cvariant G217S | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 2.7 | 0.482 | 5.5 | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C variant G217S, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin Cvariant G32V | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 10 | 0.59 | 17 | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C variant G32V, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin Cvariant P249L | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 0.6 | 0.761 | 0.79 | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C variant P249L, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin Cvariant Q178R | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 3.5 | 0.495 | 7.1 | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C variant Q178R, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin Cvariant Q48R | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 15.1 | 0.0162 | 930 | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C variant Q48R, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin Cvariant R254Q | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 15.5 | 0.0152 | 1 × 10³ | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C variant R254Q, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin Cvariant R254W | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 16.6 | 0.0151 | 1.1 × 10³ | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C variant R254W, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin Cvariant R37Q | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 14.4 | 0.0204 | 710 | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C variant R37Q, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin Cvariant V235I | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 12.6 | 0.0158 | 800 | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C variant V235I, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin Cvariant V250E | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 1.4 | 1.539 | 0.91 | pH 8, 22 °C | PMID 22942235 | Open record: chymotrypsin C variant V250E, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin C (CTRC) | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-alanine 4-nitroanilide | 0.3 | 0.3917 | 0.77 | pH 8 | PMID 23035638 | Open record: chymotrypsin C (CTRC), N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-alanine 4-nitroanilide |
| chymotrypsin C (CTRC) | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-asparagine 4-nitroanilide | 3.6 | 3.452 | 1 | pH 8 | PMID 23035638 | Open record: chymotrypsin C (CTRC), N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-asparagine 4-nitroanilide |
| chymotrypsin C (CTRC) | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-glutamine 4-nitroanilide | 1.1 | 0.7383 | 1.5 | pH 8 | PMID 23035638 | Open record: chymotrypsin C (CTRC), N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-glutamine 4-nitroanilide |
| chymotrypsin C (CTRC) | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-isoleucine 4-nitroanilide | 0.03 | 0.0605 | 0.5 | pH 8 | PMID 23035638 | Open record: chymotrypsin C (CTRC), N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-isoleucine 4-nitroanilide |
| chymotrypsin C (CTRC) | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-leucine 4-nitroanilide | 9.2 | 0.0118 | 780 | pH 8 | PMID 23035638 | Open record: chymotrypsin C (CTRC), N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-leucine 4-nitroanilide |
| chymotrypsin C (CTRC) | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-methionine 4-nitroanilide | 14.9 | 0.0304 | 490 | pH 8 | PMID 23035638 | Open record: chymotrypsin C (CTRC), N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-methionine 4-nitroanilide |
| chymotrypsin C (CTRC) | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 13.2 | 0.022 | 600 | pH 8 | PMID 23035638 | Open record: chymotrypsin C (CTRC), N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin C (CTRC) | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 15.4 | 0.0153 | 1 × 10³ | pH 8, 22 °C | PMID 26013824 | Open record: chymotrypsin C (CTRC), N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin C (CTRC) | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-tryptophan 4-nitroanilide | 0.1 | 0.0277 | 3.6 | pH 8 | PMID 23035638 | Open record: chymotrypsin C (CTRC), N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-tryptophan 4-nitroanilide |
| chymotrypsin C (CTRC) | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-tyrosine 4-nitroanilide | 16.6 | 0.0196 | 850 | pH 8 | PMID 23035638 | Open record: chymotrypsin C (CTRC), N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-tyrosine 4-nitroanilide |
| chymotrypsin C (CTRC) | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-valine 4-nitroanilide | 0.05 | 0.1504 | 0.33 | pH 8 | PMID 23035638 | Open record: chymotrypsin C (CTRC), N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-valine 4-nitroanilide |
| chymotrypsin C (CTRC)variant G214A | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 14.1 | 0.0472 | 300 | pH 8, 22 °C | PMID 26013824 | Open record: chymotrypsin C (CTRC) variant G214A, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin C (CTRC)variant G214M | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 23.6 | 0.0221 | 1.1 × 10³ | pH 8, 22 °C | PMID 26013824 | Open record: chymotrypsin C (CTRC) variant G214M, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin C (CTRC)variant G214R | Homo sapiens | ecotin | 7 × 10⁻⁴ | — | — | pH 8, 37 °C | PMID 26013824 | Open record: chymotrypsin C (CTRC) variant G214R, ecotin |
| chymotrypsin C (CTRC)variant G214R | Homo sapiens | eglin C | 0.013 | — | — | pH 8, 37 °C | PMID 26013824 | Open record: chymotrypsin C (CTRC) variant G214R, eglin C |
| chymotrypsin C (CTRC)variant G214R | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 42.2 | 0.0221 | 1.9 × 10³ | pH 8, 22 °C | PMID 26013824 | Open record: chymotrypsin C (CTRC) variant G214R, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin C (CTRC)variant I209M | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 10.3 | 0.0157 | 660 | pH 8, 22 °C | PMID 26013824 | Open record: chymotrypsin C (CTRC) variant I209M, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin C (CTRC)variant K247E | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 14.7 | 0.0167 | 880 | pH 8, 22 °C | PMID 26013824 | Open record: chymotrypsin C (CTRC) variant K247E, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin C (CTRC)variant R80Q | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 16.5 | 0.0226 | 730 | pH 8, 22 °C | PMID 26013824 | Open record: chymotrypsin C (CTRC) variant R80Q, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin C (CTRC)variant R80W | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 15.1 | 0.0194 | 780 | pH 8, 22 °C | PMID 26013824 | Open record: chymotrypsin C (CTRC) variant R80W, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin C (CTRC)variant S239A | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 11.7 | 0.019 | 620 | pH 8, 22 °C | PMID 26013824 | Open record: chymotrypsin C (CTRC) variant S239A, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |
| chymotrypsin C (CTRC)variant S239C | Homo sapiens | N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide | 0.6 | 0.0331 | 18 | pH 8, 22 °C | PMID 26013824 | Open record: chymotrypsin C (CTRC) variant S239C, N-succinyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanine 4-nitroanilide |