EC 3.4.22.59: caspase-6
HydrolasesOpen in Browse
CatLog read 29 records for EC 3.4.22.59 from 3 papers, for 1 organism. Names in these papers: caspase-6, Caspase-6.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 7 records for EC 3.4.22.59 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.22.59 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| The crystal structure of caspase-6, a selective effector of axonal degeneration | Homo sapiens | 14 |
| Identification of Allosteric Inhibitors against Active Caspase-6 | Homo sapiens | 10 |
| Zinc-mediated allosteric inhibition of caspase-6 | Homo sapiens | 5 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| caspase-6 | Homo sapiens | N-acetyl-Asp-Glu-Val-Asp-7-amino-4-methylcoumarininitial velocity; Michaelis-Menten fit (eqns 1 and 2) | 5.5 | 0.126 | 44 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Asp-Glu-Val-Asp-7-amino-4-methylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Asp-Glu-Val-Asp-7-amino-4-methylcoumarinprogress-curve method (eqns 3 and 4); [S]0 = 1 and 5 µM | — | — | 24.9 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Asp-Glu-Val-Asp-7-amino-4-methylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Asp-Glu-Val-Asp-7-amino-4-trifluoromethylcoumarin | 3.2 | 0.087 | 37 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Asp-Glu-Val-Asp-7-amino-4-trifluoromethylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Asp-Leu-Asn-Asp-7-amino-4-methylcoumarin | 0.14 | 3.6 | 0.039 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Asp-Leu-Asn-Asp-7-amino-4-methylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Asp-Val-Val-Asp-7-amino-4-methylcoumarininitial velocity; Michaelis-Menten fit (eqns 1 and 2) | 1.4 | 1.2 | 1.2 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Asp-Val-Val-Asp-7-amino-4-methylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Asp-Val-Val-Asp-7-amino-4-methylcoumarinprogress-curve method (eqns 3 and 4); [S]0 = 1 and 5 µM | — | — | 1.2 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Asp-Val-Val-Asp-7-amino-4-methylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Ile-Val-Leu-Asp-7-amino-4-methylcoumarininitial velocity; Michaelis-Menten fit (eqns 1 and 2) | 1 | 0.472 | 2.23 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Ile-Val-Leu-Asp-7-amino-4-methylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Ile-Val-Leu-Asp-7-amino-4-methylcoumarinprogress-curve method (eqns 3 and 4); [S]0 = 1 and 5 µM | — | — | 1.51 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Ile-Val-Leu-Asp-7-amino-4-methylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Thr-Glu-Val-Asp-7-amino-4-methylcoumarin | 6 | 0.0207 | 295 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Thr-Glu-Val-Asp-7-amino-4-methylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Val-Glu-Gln-Asp-7-amino-4-methylcoumarininitial velocity; Michaelis-Menten fit (eqns 1 and 2) | 4 | 0.264 | 15.5 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Val-Glu-Gln-Asp-7-amino-4-methylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Val-Glu-Gln-Asp-7-amino-4-methylcoumarinprogress-curve method (eqns 3 and 4); [S]0 = 1 and 5 µM | — | — | 17.7 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Val-Glu-Gln-Asp-7-amino-4-methylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Val-Glu-His-Asp-7-amino-4-methylcoumarininitial velocity; Michaelis-Menten fit (eqns 1 and 2) | 43 | 0.246 | 175 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Val-Glu-His-Asp-7-amino-4-methylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Val-Glu-His-Asp-7-amino-4-methylcoumarinprogress-curve method (eqns 3 and 4); [S]0 = 1 and 5 µM | — | — | 266 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Val-Glu-His-Asp-7-amino-4-methylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-methylcoumarin | 3.6 | 0.0134 | 270 | pH 7.4, 23 °C | PMID 19694615 | Open record: caspase-6, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-methylcoumarin |
| caspase-6 | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-methylcoumarin | 0.7 | 0.093 | 7.5 | pH 7.5, 25 °C | PMID 22891250 | Open record: caspase-6, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-methylcoumarin |
| Caspase-6 | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin | 2.27 | 0.0312 | 76.01 | pH 7.2, 37 °C | PMID 30940883 | Open record: Caspase-6, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin |
| Caspase-6 | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin | 2.6 | 0.0248 | 109.2 | pH 7.2, 37 °C | PMID 30940883 | Open record: Caspase-6, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin |
| Caspase-6variant A109T | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin | 2.51 | 0.0345 | 72.68 | pH 7.2, 37 °C | PMID 30940883 | Open record: Caspase-6 variant A109T, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin |
| Caspase-6variant A34E | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin | 2.04 | 0.0227 | 89.80 | pH 7.2, 37 °C | PMID 30940883 | Open record: Caspase-6 variant A34E, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin |
| caspase-6variant E244A | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-methylcoumarin | 0.051 | 0.082 | 0.6 | pH 7.5, 25 °C | PMID 22891250 | Open record: caspase-6 variant E244A, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-methylcoumarin |
| caspase-6variant E244A/H287A | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-methylcoumarin | 0.015 | 0.176 | 0.1 | pH 7.5, 25 °C | PMID 22891250 | Open record: caspase-6 variant E244A/H287A, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-methylcoumarin |
| Caspase-6variant E35K | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin | 1.71 | 0.0371 | 46.8 | pH 7.2, 37 °C | PMID 30940883 | Open record: Caspase-6 variant E35K, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin |
| caspase-6variant H287A | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-methylcoumarin | 0.309 | 0.14 | 2.2 | pH 7.5, 25 °C | PMID 22891250 | Open record: caspase-6 variant H287A, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-methylcoumarin |
| Caspase-6variant K284A | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin | 2 | 0.0326 | 58.65 | pH 7.2, 37 °C | PMID 30940883 | Open record: Caspase-6 variant K284A, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin |
| Caspase-6variant K284A | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin | 2.8 | 0.0277 | 99.88 | pH 7.2, 37 °C | PMID 30940883 | Open record: Caspase-6 variant K284A, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin |
| caspase-6variant K36A | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-methylcoumarin | 0.371 | 0.109 | 3.4 | pH 7.5, 25 °C | PMID 22891250 | Open record: caspase-6 variant K36A, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-methylcoumarin |
| Caspase-6variant L200A | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin | 0.05 | 0.3155 | 0.15 | pH 7.2, 37 °C | PMID 30940883 | Open record: Caspase-6 variant L200A, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin |
| Caspase-6variant L200A | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin | 2.8 | 0.1962 | 15.15 | pH 7.2, 37 °C | PMID 30940883 | Open record: Caspase-6 variant L200A, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin |
| Caspase-6variant T182S | Homo sapiens | N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin | 2.42 | 0.0333 | 72.65 | pH 7.2, 37 °C | PMID 30940883 | Open record: Caspase-6 variant T182S, N-acetyl-Val-Glu-Ile-Asp-7-amino-4-trifluoromethylcoumarin |