CatLogenzyme kinetics catalog

EC 3.4.24.56: insulysin

HydrolasesOpen in Browse

CatLog read 7 records for EC 3.4.24.56 from 1 paper, for 1 organism. Names in these papers: insulin-degrading enzyme (IDE).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 65 records for EC 3.4.24.56 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.24.56 in Browse.

Papers

PaperOrganismsRecords
Mutation of active site residues of insulin-degrading enzyme alters allosteric interactionsRattus norvegicus7

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
insulin-degrading enzyme (IDE)Rattus norvegicus2-aminobenzoyl-GGFLRKHGQ-N-(2,4-dinitrophenyl)ethylenediamine1.626 × 10⁵——pH 7.3PMID 15749695Open
insulin-degrading enzyme (IDE)variant E111ARattus norvegicus2-aminobenzoyl-GGFLRKHGQ-N-(2,4-dinitrophenyl)ethylenediamine17.50.20485.8 calc.pH 7.3PMID 15749695Open
insulin-degrading enzyme (IDE)variant E111FRattus norvegicus2-aminobenzoyl-GGFLRKHGQ-N-(2,4-dinitrophenyl)ethylenediamine11.40.0274416 calc.pH 7.3PMID 15749695Open
insulin-degrading enzyme (IDE)variant E111LRattus norvegicus2-aminobenzoyl-GGFLRKHGQ-N-(2,4-dinitrophenyl)ethylenediamine6.50.014460 calc.pH 7.3PMID 15749695Open
insulin-degrading enzyme (IDE)variant E111VRattus norvegicus2-aminobenzoyl-GGFLRKHGQ-N-(2,4-dinitrophenyl)ethylenediamine2.40.0156150 calc.pH 7.3PMID 15749695Open
insulin-degrading enzyme (IDE)variant H112DRattus norvegicus2-aminobenzoyl-GGFLRKHGQ-N-(2,4-dinitrophenyl)ethylenediamine23.70.0832285 calc.pH 7.3PMID 15749695Open
insulin-degrading enzyme (IDE)variant H112QRattus norvegicus2-aminobenzoyl-GGFLRKHGQ-N-(2,4-dinitrophenyl)ethylenediamine19530.15821.235 × 10⁴ calc.pH 7.3PMID 15749695Open